IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v9y2012i7p2326-2338d18630.html
   My bibliography  Save this article

Effects of Delta-Aminolevulinic Acid Dehydratase Polymorphisms on Susceptibility to Lead in Han Subjects from Southwestern China

Author

Listed:
  • Yuelin Yang

    (Department of Occupational Hygiene, West China Fourth Hospital of West China Public Health Institute, Sichuan University, 18 Renmin Nanlu, Chengdu 610041, China)

  • Jin Wu

    (Department of Internal Medicine, West China Fourth Hospital of West China Public Health Institute, Sichuan University, 18 Renmin Nanlu, Chengdu 610041, China)

  • Pin Sun

    (Department of Occupational Health, School of Public Health, Fudan University, 130 Dongan Road, Shanghai 200032, China)

Abstract

This study is to determine the distribution of the delta-aminolevulinic acid dehydratase (ALAD) polymorphism among Han subjects of the Chinese population and to study whether the polymorphism in the ALAD gene modifies the toxicity of lead in lead-exposed workers. For this purpose we conducted a cross-sectional study on 156 Chinese workers who were exposed to lead in lead-acid battery and electric-flex manufacturing plants. The authors found that the allele frequencies of ALAD1 and ALAD2 were 0.9679 and 0.0321, respectively. Workers with the ALAD 1-1 genotype were associated with higher blood lead levels than those with the ALAD 1-2 genotype. Blood and urine lead levels were much higher in storage battery workers than in cable workers. The self-conscious symptom survey showed that the incidences of debilitation, amnesia and dreaminess were much higher in those had more than five years of tenure or contact with lead on the job within the ALAD 1-1 genotype subgroup. Laboratory examinations showed that serum iron and zinc levels in workers’ with the ALAD 1-2 genotype were higher than those with the ALAD 1-1 genotype, especially in storage-battery workers. Correlation analysis indicated that the blood lead level negatively correlated with serum calcium, iron and zinc level. The data of this study suggest that the ALAD gene polymorphism and serum ion levels may modify the kinetics of lead in blood. Therefore, the authors recommend that an adequate intake of dietary calcium, iron, and zinc or the calcium, iron, and zinc supplementation should be prescribed to Chinese lead exposed workers.

Suggested Citation

  • Yuelin Yang & Jin Wu & Pin Sun, 2012. "Effects of Delta-Aminolevulinic Acid Dehydratase Polymorphisms on Susceptibility to Lead in Han Subjects from Southwestern China," IJERPH, MDPI, vol. 9(7), pages 1-13, July.
    • Handle: RePEc:gam:jijerp:v:9:y:2012:i:7:p:2326-2338:d:18630
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/9/7/2326/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/9/7/2326/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Clement G. Yedjou & Jessica N. Milner & Carolyn B. Howard & Paul B. Tchounwou, 2010. "Basic Apoptotic Mechanisms of Lead Toxicity in Human Leukemia (Hl-60) Cells," IJERPH, MDPI, vol. 7(5), pages 1-10, April.
    2. David C. Bellinger, 2011. "The Protean Toxicities of Lead: New Chapters in a Familiar Story," IJERPH, MDPI, vol. 8(7), pages 1-36, June.
    3. Koichi Miyaki & Htay Lwin & Katsunori Masaki & Yixuan Song & Yoshimitsu Takahashi & Masaaki Muramatsu & Takeo Nakayama, 2009. "Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects," IJERPH, MDPI, vol. 6(3), pages 1-11, March.
    4. Arun J. Patil & Vinod R. Bhagwat & Jyotsna A. Patil & Nilima N. Dongre & Jeevan G. Ambekar & Rama Jailkhani & Kusal K. Das, 2006. "Effect of Lead (Pb) Exposure on the Activity of Superoxide Dismutase and Catalase in Battery Manufacturing Workers (BMW) of Western Maharashtra (India) with Reference to Heme biosynthesis," IJERPH, MDPI, vol. 3(4), pages 1-9, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Petre Bretcan & Danut Tanislav & Cristiana Radulescu & Gheorghe Serban & Serban Danielescu & Michael Reid & Daniel Dunea, 2022. "Evaluation of Shallow Groundwater Quality at Regional Scales Using Adaptive Water Quality Indices," IJERPH, MDPI, vol. 19(17), pages 1-30, August.
    2. Mark A. S. Laidlaw & Dominic B. Rowe & Andrew S. Ball & Howard W. Mielke, 2015. "A Temporal Association between Accumulated Petrol (Gasoline) Lead Emissions and Motor Neuron Disease in Australia," IJERPH, MDPI, vol. 12(12), pages 1-12, December.
    3. Howard W. Mielke, 2016. "Editorial: Lead Risk Assessment and Health Effects," IJERPH, MDPI, vol. 13(6), pages 1-3, June.
    4. Moussa M. Diawara & Sofy Shrestha & Jim Carsella & Shanna Farmer, 2018. "Smelting Remains a Public Health Risk Nearly a Century Later: A Case Study in Pueblo, Colorado, USA," IJERPH, MDPI, vol. 15(5), pages 1-15, May.
    5. Howard W. Mielke & Christopher R. Gonzales & Eric T. Powell, 2017. "Soil Lead and Children’s Blood Lead Disparities in Pre- and Post-Hurricane Katrina New Orleans (USA)," IJERPH, MDPI, vol. 14(4), pages 1-12, April.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:9:y:2012:i:7:p:2326-2338:d:18630. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.