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Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects

Author

Listed:
  • Koichi Miyaki

    (Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    Department of Health Informatics, School of Public Health, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan)

  • Htay Lwin

    (Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    Department of Social and Preventive Epidemiology, School of Public Health, Graduate of School of Medicine, University of Tokyo, Japan)

  • Katsunori Masaki

    (Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan)

  • Yixuan Song

    (Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan)

  • Yoshimitsu Takahashi

    (Department of Health Informatics, School of Public Health, Graduate School of Medicine, Kyoto University, Kyoto, Japan)

  • Masaaki Muramatsu

    (Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan)

  • Takeo Nakayama

    (Department of Health Informatics, School of Public Health, Graduate School of Medicine, Kyoto University, Kyoto, Japan)

Abstract

This cross-sectional study investigated the relationship between the aminolevulinate dehydrogenase (ALAD) genotype and blood lead levels among 101 Japanese workers. Blood lead concentration measurement, biomarkers, and genotyping were performed. The minor allele frequency (MAF) for ALAD (ALAD2) was 0.08. Although the blood lead level in the subjects with heterozygous GC genotype was significantly higher than those with homozygous GG genotype, there were no significant differences for hemoglobin, hematocrit, serum and urinary ALA levels among genotypes. ALAD2 genotype was significantly associated with the blood lead concentration, even in the environmental lead exposed subjects. Further confirmation with a large sample size is needed.

Suggested Citation

  • Koichi Miyaki & Htay Lwin & Katsunori Masaki & Yixuan Song & Yoshimitsu Takahashi & Masaaki Muramatsu & Takeo Nakayama, 2009. "Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects," IJERPH, MDPI, vol. 6(3), pages 1-11, March.
    • Handle: RePEc:gam:jijerp:v:6:y:2009:i:3:p:999-1009:d:4210
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    References listed on IDEAS

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    1. Hu, H., 1991. "Knowledge of diagnosis and reproductive history among survivors of childhood plumbism," American Journal of Public Health, American Public Health Association, vol. 81(8), pages 1070-1072.
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    Cited by:

    1. Moussa M. Diawara & Sofy Shrestha & Jim Carsella & Shanna Farmer, 2018. "Smelting Remains a Public Health Risk Nearly a Century Later: A Case Study in Pueblo, Colorado, USA," IJERPH, MDPI, vol. 15(5), pages 1-15, May.
    2. Yuelin Yang & Jin Wu & Pin Sun, 2012. "Effects of Delta-Aminolevulinic Acid Dehydratase Polymorphisms on Susceptibility to Lead in Han Subjects from Southwestern China," IJERPH, MDPI, vol. 9(7), pages 1-13, July.

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