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Effect of Lead (Pb) Exposure on the Activity of Superoxide Dismutase and Catalase in Battery Manufacturing Workers (BMW) of Western Maharashtra (India) with Reference to Heme biosynthesis

Author

Listed:
  • Arun J. Patil

    (Department of Biochemistry, B.L.D.E.A’s Shri B. M. Patil Medical College, Bijapur, Karnataka, Pin-586103, India)

  • Vinod R. Bhagwat

    (Department of Biochemistry, Govt. Medical College, Dhule, Maharshtra, India)

  • Jyotsna A. Patil

    (Department of Biochemistry, B.L.D.E.A’s Shri B. M. Patil Medical College, Bijapur, Karnataka, Pin-586103, India)

  • Nilima N. Dongre

    (Department of Biochemistry, B.L.D.E.A’s Shri B. M. Patil Medical College, Bijapur, Karnataka, Pin-586103, India)

  • Jeevan G. Ambekar

    (Department of Biochemistry, B.L.D.E.A’s Shri B. M. Patil Medical College, Bijapur, Karnataka, Pin-586103, India)

  • Rama Jailkhani

    (Department of Biochemistry, SDM Institute of Medical Sciences, Dharwad, Karnataka, India)

  • Kusal K. Das

    (Department of Physiology, Al Ameen Medical College, Bijapur, Karnataka, Pin-586108, India)

Abstract

The aim of this study was to estimate the activity of superoxide dismutase (SOD) and catalase in erythrocytes and malondialdehyde (MDA) in plasma of battery manufacturing workers (BMW) of Western Maharashtra (India) who were occupationally exposed to lead (Pb) over a long period of time (about 15 years). This study was also aimed to determine the Pb intoxication resulted in a disturbance of heme biosynthesis in BMW group. The blood Pb level of BMW group (n = 28) was found to be in the range of 25.8 – 78.0 μg/dL (mean + SD, 53.63 + 16.98) whereas in Pb unexposed control group (n = 35) the range was 2.8 – 22.0 μg/dL (mean + SD, 12.52 + 4.08). The blood level (Pb-B) and urinary lead level (Pb-U) were significantly increased in BMW group as compared to unexposed control. Though activated d- aminolevulinic acid dehydratase (ALAD) activities in BMW group did not show any significant change when compared to control group but activated / non activated erythrocyte – ALAD activities in BMW group showed a significant increase. Erythrocyte- zinc protoporphyrin (ZPP), urinary daminolevulinic acid (ALA-U) and porphobilinogen (PBG-U) of BMW groups elevated significantly as compared to control. A positive correlation (r = 0.66, p 1.0) were observed in control group. Hematological study revealed a significant decrease of hemoglobin concentration, packed cell volume (%) and other blood indices and a significant increase of total leucocytes count in BMW group in comparison to control group. The serum MDA content was significantly increased (p

Suggested Citation

  • Arun J. Patil & Vinod R. Bhagwat & Jyotsna A. Patil & Nilima N. Dongre & Jeevan G. Ambekar & Rama Jailkhani & Kusal K. Das, 2006. "Effect of Lead (Pb) Exposure on the Activity of Superoxide Dismutase and Catalase in Battery Manufacturing Workers (BMW) of Western Maharashtra (India) with Reference to Heme biosynthesis," IJERPH, MDPI, vol. 3(4), pages 1-9, December.
    • Handle: RePEc:gam:jijerp:v:3:y:2006:i:4:p:329-337:d:2409
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    Cited by:

    1. Yuelin Yang & Jin Wu & Pin Sun, 2012. "Effects of Delta-Aminolevulinic Acid Dehydratase Polymorphisms on Susceptibility to Lead in Han Subjects from Southwestern China," IJERPH, MDPI, vol. 9(7), pages 1-13, July.

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