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Association of Lung Fibrotic Changes and Cardiological Dysfunction with Comorbidities in Long COVID-19 Cohort

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Listed:
  • Ainur T. Tauekelova

    (National Research Center for Cardiac Surgery, Astana 010000, Kazakhstan)

  • Zhanar Kalila

    (National Research Center for Cardiac Surgery, Astana 010000, Kazakhstan)

  • Akerke Bakhtiyar

    (National Research Center for Cardiac Surgery, Astana 010000, Kazakhstan)

  • Zarina Sautbayeva

    (School of Sciences and Humanities, Nazarbayev University, Astana 010000, Kazakhstan)

  • Polina Len

    (School of Sciences and Humanities, Nazarbayev University, Astana 010000, Kazakhstan)

  • Aliya Sailybayeva

    (National Research Center for Cardiac Surgery, Astana 010000, Kazakhstan)

  • Sadyk Khamitov

    (National Research Center for Cardiac Surgery, Astana 010000, Kazakhstan)

  • Nazira Kadroldinova

    (School of Medicine, Nazarbayev University, Astana 020000, Kazakhstan)

  • Natasha S. Barteneva

    (School of Sciences and Humanities, Nazarbayev University, Astana 010000, Kazakhstan)

  • Makhabbat S. Bekbossynova

    (National Research Center for Cardiac Surgery, Astana 010000, Kazakhstan)

Abstract

Background . Long COVID-19 symptoms appeared in many COVID-19 survivors. However, the prevalence and symptoms associated with long COVID-19 and its comorbidities have not been established. Methods . In total, 312 patients with long COVID-19 from 21 primary care centers were included in the study. At the six-month follow-up, their lung function was assessed by computerized tomography (CT) and spirometry, whereas cardiac function was assessed by electrocardiogram, Holter ECG, echocardiography, 24 h blood pressure monitoring, and a six-minute walk test (6MWT). Results . Of the 312 persons investigated, significantly higher systolic and diastolic blood pressure, left ventricular hypertrophy, and elevated NT-proBNP were revealed in participants with hypertension or type 2 diabetes. Left ventricular diastolic dysfunction was more frequently present in patients with hypertension. The most common registered CT abnormalities were fibrotic changes (83, 36.6%) and mediastinal lymphadenopathy (23, 10.1%). Among the tested biochemical parameters, three associations were found in long COVID-19 patients with hypertension but not diabetes: increased hemoglobin, fibrinogen, and ferritin. Nine patients had persisting IgM antibodies to SARS-CoV-2. Conclusions . We demonstrated a strong association between signs of cardiac dysfunction and lung fibrotic changes with comorbidities in a cohort of long COVID-19 subjects.

Suggested Citation

  • Ainur T. Tauekelova & Zhanar Kalila & Akerke Bakhtiyar & Zarina Sautbayeva & Polina Len & Aliya Sailybayeva & Sadyk Khamitov & Nazira Kadroldinova & Natasha S. Barteneva & Makhabbat S. Bekbossynova, 2023. "Association of Lung Fibrotic Changes and Cardiological Dysfunction with Comorbidities in Long COVID-19 Cohort," IJERPH, MDPI, vol. 20(3), pages 1-18, January.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:3:p:2567-:d:1052992
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    References listed on IDEAS

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    1. Ziyad Al-Aly & Yan Xie & Benjamin Bowe, 2021. "High-dimensional characterization of post-acute sequelae of COVID-19," Nature, Nature, vol. 594(7862), pages 259-264, June.
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