IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v20y2022i1p111-d1010884.html
   My bibliography  Save this article

The 8-Week Efficacy of Frequency Rhythmic Electrical Modulated System (FREMS) as an Add-on Therapy in the Treatment of Symptomatic Diabetic Peripheral Polyneuropathy

Author

Listed:
  • Daria Gorczyca-Siudak

    (Faculty of Human Sciences, University of Economics and Innovation, St. 4 Projektowa, 20-209 Lublin, Poland)

  • Piotr Dziemidok

    (Faculty of Human Sciences, University of Economics and Innovation, St. 4 Projektowa, 20-209 Lublin, Poland)

Abstract

Background: Frequency Rhythmic Electrical Modulated System (FREMS) is a method of transcutaneous treatment based on frequency-modulated electromagnetic neural stimulation. Its efficacy in neuropathic pain in diabetes mellitus still lacks enough research. Methods: A randomized, single-blind, sham-controlled trial in individuals with symmetric distal polyneuropathy (SDPN) as an add-on therapy compared to standard therapy with alpha-lipoic acid. Participants were randomized to FREMS and standard of care (SOC) versus SOC only. The primary outcome was a change from baseline in perceived pain assessed by visual analogue scale (VAS) after 5 days of treatment and after 8 weeks of follow-up between treatment groups. Results: After 5 days of treatment, patients in both groups felt significant reduction in pain as measured by VAS, although only FREMS treatment lasted for 8 weeks and induced a significant improvement in quality of life measured by EuroQol 5-Dimension 5-Level (EQ-5D-5L) and Clinical Global Impression of Change (CGI-C) questionnaires. There were non-significant differences observed in the instrument pain assessment. No relevant side effects were recorded during the study. Conclusions: FREMS as an addition to alpha-lipoic acid therapy occurred to be a beneficial method of treatment in individuals with SDPN and was associated with improvements in pain severity, quality of life and clinical global improvement.

Suggested Citation

  • Daria Gorczyca-Siudak & Piotr Dziemidok, 2022. "The 8-Week Efficacy of Frequency Rhythmic Electrical Modulated System (FREMS) as an Add-on Therapy in the Treatment of Symptomatic Diabetic Peripheral Polyneuropathy," IJERPH, MDPI, vol. 20(1), pages 1-11, December.
    • Handle: RePEc:gam:jijerp:v:20:y:2022:i:1:p:111-:d:1010884
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/20/1/111/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/20/1/111/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Milad Karimi & John Brazier, 2016. "Health, Health-Related Quality of Life, and Quality of Life: What is the Difference?," PharmacoEconomics, Springer, vol. 34(7), pages 645-649, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Octavio Pano & Carmen Sayón-Orea & Alfredo Gea & Maira Bes-Rastrollo & Miguel Ángel Martínez-González & J. Alfredo Martínez, 2020. "Nutritional Determinants of Quality of Life in a Mediterranean Cohort: The SUN Study," IJERPH, MDPI, vol. 17(11), pages 1-17, May.
    2. Suparb Aree‐Ue & Usa Kongsombun & Inthira Roopsawang & Phichpraorn Youngcharoen, 2019. "Path model of factors influencing health‐related quality of life among older people with knee osteoarthritis," Nursing & Health Sciences, John Wiley & Sons, vol. 21(3), pages 345-351, September.
    3. Ariana Amariles-Baena & Catalina Sosa-Palacio & Andrés A. Agudelo-Suárez, 2022. "Quality of Life and Related Factors in Specialists on Pediatric Dentistry and the like Graduated from a Public University: A Mixed Methods Approach," IJERPH, MDPI, vol. 19(20), pages 1-22, October.
    4. Marc Audi & Amjad Ali, 2023. "The Role of Environmental Conditions and Purchasing Power Parity in Determining Quality of Life among Big Asian Cities," International Journal of Energy Economics and Policy, Econjournals, vol. 13(3), pages 292-305, May.
    5. Le Grande, M. & Ski, C.F. & Thompson, D.R. & Scuffham, P. & Kularatna, S. & Jackson, A.C. & Brown, A., 2017. "Social and emotional wellbeing assessment instruments for use with Indigenous Australians: A critical review," Social Science & Medicine, Elsevier, vol. 187(C), pages 164-173.
    6. María Dolores Ruiz-Fernández & Ángela María Ortega-Galán & Cayetano Fernández-Sola & José Manuel Hernández-Padilla & José Granero-Molina & Juan Diego Ramos-Pichardo, 2020. "Occupational Factors Associated with Health-Related Quality of Life in Nursing Professionals: A Multi-Centre Study," IJERPH, MDPI, vol. 17(3), pages 1-12, February.
    7. Shu‐Fang Chang & Shu‐Ching Chiu, 2020. "Effect of resistance training on quality of life in older people with sarcopenic obesity living in long‐term care institutions: A quasi‐experimental study," Journal of Clinical Nursing, John Wiley & Sons, vol. 29(13-14), pages 2544-2556, July.
    8. Tessa Peasgood & Jill Carlton & John Brazier, 2019. "A Qualitative Study of the Views of Health and Social Care Decision-Makers on the Role of Wellbeing in Resource Allocation Decisions in the UK," Economies, MDPI, vol. 7(1), pages 1-13, February.
    9. Andrés A. Agudelo-Suárez & Annie M. Vivares-Builes & Natalia Muñoz-Pino & José Miguel Martínez-Martínez & Alison Reid & Elena Ronda-Pérez, 2019. "Oral Health-Related Quality of Life in Native and Immigrant Populations in the PELFI Study in Spain," IJERPH, MDPI, vol. 16(10), pages 1-14, May.
    10. Billingsley Kaambwa & Hailay Abrha Gesesew & Matthew Horsfall & Derek Chew, 2020. "Quality of Life Changes in Acute Coronary Syndromes Patients: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 17(18), pages 1-28, September.
    11. Nadine Simo & Denis Boucaud-Maitre & Pierre Gebhard & Roxane Villeneuve & Leila Rinaldo & Jean-François Dartigues & Moustapha Drame & Maturin Tabue-Teguo, 2023. "Correlates of Health-Related Quality of Life in Community-Dwelling Older Adults in Guadeloupe (French West Indies): Results from the KASADS Study," IJERPH, MDPI, vol. 20(4), pages 1-9, February.
    12. Sollis, Kate & Yap, Mandy & Campbell, Paul & Biddle, Nicholas, 2022. "Conceptualisations of wellbeing and quality of life: A systematic review of participatory studies," World Development, Elsevier, vol. 160(C).
    13. Ian Ross & Giulia Greco & Charles Opondo & Zaida Adriano & Rassul Nala & Joe Brown & Robert Dreibelbis & Oliver Cumming, 2022. "Measuring and valuing broader impacts in public health: Development of a sanitation‐related quality of life instrument in Maputo, Mozambique," Health Economics, John Wiley & Sons, Ltd., vol. 31(3), pages 466-480, March.
    14. Abraham G. Welie & Elly Stolk & Clara Mukuria & Yared Belete Belay & Murray D. Krahn & Beate Sander & Gebremedhin Beedemariam Gebretekle, 2022. "Reliability and validity of using EQ-5D-5L among healthy and adolescents with major mental health disorders in Ethiopia," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 23(7), pages 1105-1119, September.
    15. Wilmer A. Romo-Cabrera & Andrés A. Agudelo-Suárez, 2022. "A Comprehensive Mixed Methods Approach for Studying the Quality of Life of Colombian Periodontists," IJERPH, MDPI, vol. 19(23), pages 1-20, December.
    16. Binyu Liu & Ye Chen & Meng Xiao, 2020. "The Social Utility and Health Benefits for Older Adults of Amenity Buildings in China’s Urban Parks: A Nanjing Case Study," IJERPH, MDPI, vol. 17(20), pages 1-26, October.
    17. Victoria Gale & Jill Carlton, 2023. "Including Young Children in the Development and Testing of Patient Reported Outcome (PRO) Instruments: A Scoping Review of Children’s Involvement and Qualitative Methods," The Patient: Patient-Centered Outcomes Research, Springer;International Academy of Health Preference Research, vol. 16(5), pages 425-456, September.
    18. Andrea Higuera-Gómez & Rosa Ribot-Rodríguez & Victor Micó & Amanda Cuevas-Sierra & Rodrigo San Cristóbal & Jose Alfredo Martínez, 2022. "Lifestyle and Health-Related Quality of Life Relationships Concerning Metabolic Disease Phenotypes on the Nutrimdea Online Cohort," IJERPH, MDPI, vol. 20(1), pages 1-19, December.
    19. Emilie Rune Hegelund & Anna Paldam Folker & Cathrine Lawaetz Wimmelmann & Emilie Just-Østergaard & Erik Lykke Mortensen & Trine Flensborg-Madsen, 2020. "Infant Socioeconomic Position and Quality of Life in Midlife: A 50-Year Follow-Up Study of 2079 Individuals in Denmark," Applied Research in Quality of Life, Springer;International Society for Quality-of-Life Studies, vol. 15(4), pages 937-951, September.
    20. Yunjie Luo & Yoko Sato, 2021. "Health-Related Quality of Life and Risk Factors among Chinese Women in Japan Following the COVID-19 Outbreak," IJERPH, MDPI, vol. 18(16), pages 1-13, August.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:20:y:2022:i:1:p:111-:d:1010884. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.