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Choosing between Homologous or Heterologous COVID-19 Vaccination Regimens: A Cross-Sectional Study among the General Population in Italy

Author

Listed:
  • Marco Clari

    (Department of Public Health and Pediatrics, University of Torino, 10126 Turin, Italy)

  • Alessandro Godono

    (Department of Public Health and Pediatrics, University of Torino, 10126 Turin, Italy)

  • Beatrice Albanesi

    (Department of Public Health and Pediatrics, University of Torino, 10126 Turin, Italy)

  • Elena Casabona

    (Department of Public Health and Pediatrics, University of Torino, 10126 Turin, Italy)

  • Rosanna Irene Comoretto

    (Department of Public Health and Pediatrics, University of Torino, 10126 Turin, Italy)

  • Ihab Mansour

    (Department of Public Health and Pediatrics, University of Torino, 10126 Turin, Italy)

  • Alessio Conti

    (Department of Public Health and Pediatrics, University of Torino, 10126 Turin, Italy)

  • Valerio Dimonte

    (Department of Public Health and Pediatrics, University of Torino, 10126 Turin, Italy
    Città Della Salute e Della Scienza University Hospital, 10126 Turin, Italy)

  • Catalina Ciocan

    (Department of Public Health and Pediatrics, University of Torino, 10126 Turin, Italy
    Città Della Salute e Della Scienza University Hospital, 10126 Turin, Italy)

Abstract

A shortage of COVID-19 vaccines and reports of side-effects led several countries to recommend a heterologous regimen for second vaccine doses. This study aimed to describe the reasons behind individuals’ choices of a homologous or a heterologous second vaccination. This cross-sectional study enrolled individuals under 60 who had received a first dose of Vaxzevria and could choose between a homologous or heterologous regimen for their second dose. Quantitative (socio-demographic, clinical characteristics) and qualitative data were collected and analysed through a generalized linear model and thematic analysis, respectively. Of the 1437 individuals included in the analysis, the majority (76.1%) chose a heterologous second dose of the COVID-19 vaccination. More females chose a heterologous vaccination regimen ( p = 0.003). Younger individuals also tended to choose heterologous vaccination ( p < 0.001). The main motivation in favour of heterologous vaccination was to follow the Italian Ministry of Health recommendations ( n = 118; 53.9%). This study showed that most individuals, mainly younger people and females, chose a heterologous dose of COVID-19 vaccination after their first viral vector vaccine. Heterologous vaccinations could be an effective public health measure to control the pandemic as they are a safe and efficient alternative to homologous regimens.

Suggested Citation

  • Marco Clari & Alessandro Godono & Beatrice Albanesi & Elena Casabona & Rosanna Irene Comoretto & Ihab Mansour & Alessio Conti & Valerio Dimonte & Catalina Ciocan, 2022. "Choosing between Homologous or Heterologous COVID-19 Vaccination Regimens: A Cross-Sectional Study among the General Population in Italy," IJERPH, MDPI, vol. 19(5), pages 1-9, March.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:5:p:2944-:d:763016
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    References listed on IDEAS

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    1. Patrick Sturgis & Ian Brunton-Smith & Jonathan Jackson, 2021. "Trust in science, social consensus and vaccine confidence," Nature Human Behaviour, Nature, vol. 5(11), pages 1528-1534, November.
    2. Krishna Regmi & Cho Mar Lwin, 2021. "Factors Associated with the Implementation of Non-Pharmaceutical Interventions for Reducing Coronavirus Disease 2019 (COVID-19): A Systematic Review," IJERPH, MDPI, vol. 18(8), pages 1-27, April.
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