Author
Listed:
- Thi Tham Nguyen
(School of Public Health, The University of Queensland, Brisbane, QLD 4006, Australia)
- Congrong He
(International Laboratory for Air Quality & Health, School of Earth and Atmospheric Sciences, Faculty of Science, Queensland University of Technology (QUT), Brisbane, QLD 4000, Australia
These authors contributed equally to this work.)
- Robyn Carter
(Centre for Children’s Health Research, Brisbane, QLD 4101, Australia
These authors contributed equally to this work.)
- Emma L. Ballard
(QIMR Berghofer Institute of Medical Research, Brisbane, QLD 4006, Australia)
- Kim Smith
(Centre for Children’s Health Research, Brisbane, QLD 4101, Australia)
- Robert Groth
(International Laboratory for Air Quality & Health, School of Earth and Atmospheric Sciences, Faculty of Science, Queensland University of Technology (QUT), Brisbane, QLD 4000, Australia)
- Esa Jaatinen
(School of Chemistry and Physics, Queensland University of Technology (QUT), Brisbane, QLD 4000, Australia)
- Timothy J. Kidd
(School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4032, Australia
Pathology Queensland, Royal Brisbane and Women’s Hospital, Brisbane, QLD 4006, Australia)
- Thuy-Khanh Nguyen
(QIMR Berghofer Institute of Medical Research, Brisbane, QLD 4006, Australia)
- Rebecca E. Stockwell
(QIMR Berghofer Institute of Medical Research, Brisbane, QLD 4006, Australia)
- George Tay
(The Prince Charles Hospital, Brisbane, QLD 4032, Australia)
- Graham R. Johnson
(International Laboratory for Air Quality & Health, School of Earth and Atmospheric Sciences, Faculty of Science, Queensland University of Technology (QUT), Brisbane, QLD 4000, Australia)
- Scott C. Bell
(Centre for Children’s Health Research, Brisbane, QLD 4101, Australia
The Prince Charles Hospital, Brisbane, QLD 4032, Australia
Faculty of Medicine, The University of Queensland, Brisbane, QLD 4006, Australia
Translational Research Institute, Brisbane, QLD 4102, Australia)
- Luke D. Knibbs
(Public Health Unit, Sydney Local Health District, Camperdown, NSW 2050, Australia
Faculty of Medicine and Health, School of Public Health, The University of Sydney, Sydney, NSW 2006, Australia
These authors contributed equally to this work.)
Abstract
Pseudomonas aeruginosa ( Pa ) is the predominant bacterial pathogen in people with cystic fibrosis (CF) and can be transmitted by airborne droplet nuclei. Little is known about the ability of ultraviolet band C (UV-C) irradiation to inactivate Pa at doses and conditions relevant to implementation in indoor clinical settings. We assessed the effectiveness of UV-C (265 nm) at up to seven doses on the decay of nebulized Pa aerosols (clonal Pa strain) under a range of experimental conditions. Experiments were done in a 400 L rotating sampling drum. A six-stage Andersen cascade impactor was used to collect aerosols inside the drum and the particle size distribution was characterized by an optical particle counter. UV-C effectiveness was characterized relative to control tests (no UV-C) of the natural decay of Pa . We performed 112 tests in total across all experimental conditions. The addition of UV-C significantly increased the inactivation of Pa compared with natural decay alone at all but one of the UV-C doses assessed. UV-C doses from 246–1968 µW s/cm 2 had an estimated effectiveness of approximately 50–90% for airborne Pa . The effectiveness of doses ≥984 µW s/cm 2 were not significantly different from each other ( p -values: 0.365 to ~1), consistent with a flattening of effectiveness at higher doses. Modelling showed that delivering the highest dose associated with significant improvement in effectiveness (984 µW s/cm 2 ) to the upper air of three clinical rooms would lead to lower room doses from 37–49% of the 8 h occupational limit. Our results suggest that UV-C can expedite the inactivation of nebulized airborne Pa under controlled conditions, at levels that can be delivered safely in occupied settings. These findings need corroboration, but UV-C may have potential applications in locations where people with CF congregate, coupled with other indoor and administrative infection control measures.
Suggested Citation
Thi Tham Nguyen & Congrong He & Robyn Carter & Emma L. Ballard & Kim Smith & Robert Groth & Esa Jaatinen & Timothy J. Kidd & Thuy-Khanh Nguyen & Rebecca E. Stockwell & George Tay & Graham R. Johnson &, 2022.
"The Effectiveness of Ultraviolet-C (UV-C) Irradiation on the Viability of Airborne Pseudomonas aeruginosa,"
IJERPH, MDPI, vol. 19(20), pages 1-15, October.
Handle:
RePEc:gam:jijerp:v:19:y:2022:i:20:p:13706-:d:949775
Download full text from publisher
References listed on IDEAS
- Giulia Baldelli & Mattia Paolo Aliano & Giulia Amagliani & Mauro Magnani & Giorgio Brandi & Carmelo Pennino & Giuditta Fiorella Schiavano, 2022.
"Airborne Microorganism Inactivation by a UV-C LED and Ionizer-Based Continuous Sanitation Air (CSA) System in Train Environments,"
IJERPH, MDPI, vol. 19(3), pages 1-12, January.
- Marta Rachel & Stanisław Topolewicz & Andrzej Śliwczyński & Sabina Galiniak, 2020.
"Managing Cystic Fibrosis in Polish Healthcare,"
IJERPH, MDPI, vol. 17(20), pages 1-17, October.
- Thi Tham Nguyen & Graham R. Johnson & Scott C. Bell & Luke D. Knibbs, 2022.
"A Systematic Literature Review of Indoor Air Disinfection Techniques for Airborne Bacterial Respiratory Pathogens,"
IJERPH, MDPI, vol. 19(3), pages 1-12, January.
Full references (including those not matched with items on IDEAS)
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