Author
Listed:
- Laila N. Islam
(Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka-1000, Bangladesh)
- AHM Nurun Nabi
(Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka-1000, Bangladesh)
- M Mahfuzur Rahman
(Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka-1000, Bangladesh)
- Monsur A. Khan
(Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka-1000, Bangladesh)
- Azizul I. Kazi
(Bangladesh Council of Scientific and Industrial Research (BCSIR), Mirpur Road, Dhaka, Bangladesh)
Abstract
This study conducted in Bangladesh reports the relationship of clinical complications with nutritional status and the prevalence of leukopenia among arsenic exposed patients living in the rural villages. A total of 115 exposed individuals diagnosed as arsenicosis patients were randomly selected from four known arsenic endemic villages, and age-matched 120 unexposed subjects were enrolled in the study program. The duration of arsenic exposure in about 37% of the patients was at least 10 yrs, while the population mean and range were 7.6 ± 5.2 yrs, and 1 – 25 yrs, respectively. The mean arsenic concentrations in the drinking water for the exposed and unexposed (control) population were 218.1 μg/L and 11.3 μg/L, respectively. The spot urine sample of the arsenicosis patients contained an average of 234.6 μg/L arsenic. Although very few patients showed elevated WBC count, 16% had leukopenia (below normal count), and the whole population had significantly low WBC count than the control subjects. Prevalences of neutropenia and lymphocytosis were observed in patients with chronic exposure to high levels of arsenic in water. The body mass index was found to be lower than 18.5, the cut-off point for malnutrition (underweight), in about 28% of the arsenicosis cases compared to 15% of the controls. The monthly income and total calorie consumption per day showed the patients were underprivileged than the controls. Arsenical symptoms and complications were more severe in the nutritionally vulnerable (underweight) patients than the overweight ones. Also, the incidences of leukopenia and anaemia were more common in the female patients who were underweight. The findings of this research demonstrate that the poor nutritional status of patients increases the complications of chronic arsenic toxicity; suggest the possibility of other sources of arsenic contamination different from drinking water in the study area; and establish a higher prevalence of leukopenia and lymphocytosis in arsenicosis patients.
Suggested Citation
Laila N. Islam & AHM Nurun Nabi & M Mahfuzur Rahman & Monsur A. Khan & Azizul I. Kazi, 2004.
"Association of Clinical Complications with Nutritional Status and the Prevalence of Leukopenia among Arsenic Patients in Bangladesh,"
IJERPH, MDPI, vol. 1(2), pages 1-9, September.
Handle:
RePEc:gam:jijerp:v:1:y:2004:i:2:p:74-82:d:2789
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Citations
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Cited by:
- Mohammad H. Rahbar & Maureen Samms-Vaughan & Yuansong Zhao & Sepideh Saroukhani & Sheikh F. Zaman & Jan Bressler & Manouchehr Hessabi & Megan L. Grove & Sydonnie Shakspeare-Pellington & Katherine A. L, 2022.
"Additive and Interactive Associations of Environmental and Sociodemographic Factors with the Genotypes of Three Glutathione S-Transferase Genes in Relation to the Blood Arsenic Concentrations of Child,"
IJERPH, MDPI, vol. 19(1), pages 1-19, January.
- A. H. M. Nurun Nabi & M. Mahfuzur Rahman & Laila N. Islam, 2005.
"Evaluation of Biochemical Changes in Chronic Arsenic Poisoning among Bangladeshi Patients,"
IJERPH, MDPI, vol. 2(3), pages 1-9, December.
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