IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v535y2016i7610d10.1038_nature18848.html
   My bibliography  Save this article

The microbiota in adaptive immune homeostasis and disease

Author

Listed:
  • Kenya Honda

    (Keio University School of Medicine
    RIKEN Center for Integrative Medical Sciences, Tsurumi, Yokohama
    AMED-CREST, Chiyoda)

  • Dan R. Littman

    (The Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine
    The Howard Hughes Medical Institute, New York University School of Medicine)

Abstract

In the mucosa, the immune system's T cells and B cells have position-specific phenotypes and functions that are influenced by the microbiota. These cells play pivotal parts in the maintenance of immune homeostasis by suppressing responses to harmless antigens and by enforcing the integrity of the barrier functions of the gut mucosa. Imbalances in the gut microbiota, known as dysbiosis, can trigger several immune disorders through the activity of T cells that are both near to and distant from the site of their induction. Elucidation of the mechanisms that distinguish between homeostatic and pathogenic microbiota–host interactions could identify therapeutic targets for preventing or modulating inflammatory diseases and for boosting the efficacy of cancer immunotherapy.

Suggested Citation

  • Kenya Honda & Dan R. Littman, 2016. "The microbiota in adaptive immune homeostasis and disease," Nature, Nature, vol. 535(7610), pages 75-84, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7610:d:10.1038_nature18848
    DOI: 10.1038/nature18848
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature18848
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature18848?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Alexandre Soares Ferreira-Junior & Tais Fernanda Borgonovi & Larissa Vedovato Vilela De Salis & Aline Zazeri Leite & Amanda Soares Dantas & Guilherme Vedovato Vilela De Salis & Giuliano Netto Flores C, 2022. "Detection of Intestinal Dysbiosis in Post-COVID-19 Patients One to Eight Months after Acute Disease Resolution," IJERPH, MDPI, vol. 19(16), pages 1-15, August.
    2. Arles Urrutia & Víctor A García-Angulo & Andrés Fuentes & Mauricio Caneo & Marcela Legüe & Sebastián Urquiza & Scarlett E Delgado & Juan Ugalde & Paula Burdisso & Andrea Calixto, 2020. "Bacterially produced metabolites protect C. elegans neurons from degeneration," PLOS Biology, Public Library of Science, vol. 18(3), pages 1-31, March.
    3. Bharati Patel & Kadamb Patel & Shabbir Moochhala, 2020. "Diet-Derived Post-Biotic Metabolites to Promote Microbiota Function and Human Health," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 28(2), pages 21520-21524, June.
    4. Carlos David Grande-Tovar & Domingo Cesar Carrascal-Hernández & Jorge Trilleras & Katelediana Mora & Victoria A. Arana, 2022. "Microplastics’ and Nanoplastics’ Interactions with Microorganisms: A Bibliometric Study," Sustainability, MDPI, vol. 14(22), pages 1-26, November.
    5. Jansller Luiz Genova & Antonio Diego Brandao Melo & Paulo Evaristo Rupolo & Silvana Teixeira Carvalho & Leandro Batista Costa & Paulo Levi de Oliveira Carvalho, 2020. "A summary of feed additives, intestinal health and intestinal alkaline phosphatase in piglet nutrition," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 65(8), pages 281-294.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:535:y:2016:i:7610:d:10.1038_nature18848. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.