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The microbiota in adaptive immune homeostasis and disease

Author

Listed:
  • Kenya Honda

    (Keio University School of Medicine
    RIKEN Center for Integrative Medical Sciences, Tsurumi, Yokohama
    AMED-CREST, Chiyoda)

  • Dan R. Littman

    (The Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine
    The Howard Hughes Medical Institute, New York University School of Medicine)

Abstract

In the mucosa, the immune system's T cells and B cells have position-specific phenotypes and functions that are influenced by the microbiota. These cells play pivotal parts in the maintenance of immune homeostasis by suppressing responses to harmless antigens and by enforcing the integrity of the barrier functions of the gut mucosa. Imbalances in the gut microbiota, known as dysbiosis, can trigger several immune disorders through the activity of T cells that are both near to and distant from the site of their induction. Elucidation of the mechanisms that distinguish between homeostatic and pathogenic microbiota–host interactions could identify therapeutic targets for preventing or modulating inflammatory diseases and for boosting the efficacy of cancer immunotherapy.

Suggested Citation

  • Kenya Honda & Dan R. Littman, 2016. "The microbiota in adaptive immune homeostasis and disease," Nature, Nature, vol. 535(7610), pages 75-84, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7610:d:10.1038_nature18848
    DOI: 10.1038/nature18848
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    Cited by:

    1. Bharati Patel & Kadamb Patel & Shabbir Moochhala, 2020. "Diet-Derived Post-Biotic Metabolites to Promote Microbiota Function and Human Health," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 28(2), pages 21520-21524, June.
    2. Jansller Luiz Genova & Antonio Diego Brandao Melo & Paulo Evaristo Rupolo & Silvana Teixeira Carvalho & Leandro Batista Costa & Paulo Levi de Oliveira Carvalho, 2020. "A summary of feed additives, intestinal health and intestinal alkaline phosphatase in piglet nutrition," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 65(8), pages 281-294.
    3. Alexandre Soares Ferreira-Junior & Tais Fernanda Borgonovi & Larissa Vedovato Vilela De Salis & Aline Zazeri Leite & Amanda Soares Dantas & Guilherme Vedovato Vilela De Salis & Giuliano Netto Flores C, 2022. "Detection of Intestinal Dysbiosis in Post-COVID-19 Patients One to Eight Months after Acute Disease Resolution," IJERPH, MDPI, vol. 19(16), pages 1-15, August.
    4. Arles Urrutia & Víctor A García-Angulo & Andrés Fuentes & Mauricio Caneo & Marcela Legüe & Sebastián Urquiza & Scarlett E Delgado & Juan Ugalde & Paula Burdisso & Andrea Calixto, 2020. "Bacterially produced metabolites protect C. elegans neurons from degeneration," PLOS Biology, Public Library of Science, vol. 18(3), pages 1-31, March.
    5. Carlos David Grande-Tovar & Domingo Cesar Carrascal-Hernández & Jorge Trilleras & Katelediana Mora & Victoria A. Arana, 2022. "Microplastics’ and Nanoplastics’ Interactions with Microorganisms: A Bibliometric Study," Sustainability, MDPI, vol. 14(22), pages 1-26, November.

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