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The Impact of COVID-19 Infection on Cognitive Function and the Implication for Rehabilitation: A Systematic Review and Meta-Analysis

Author

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  • Sarah Houben

    (Scientific Direction Infectious Diseases in Humans, Sciensano, 1050 Brussels, Belgium)

  • Bruno Bonnechère

    (REVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, 3590 Diepenbeek, Belgium
    Technology-Supported and Data-Driven Rehabilitation, Data Sciences Institute, Hasselt University, 3590 Diepenbeek, Belgium)

Abstract

There is mounting evidence that patients with severe COVID-19 disease may have symptoms that continue beyond the acute phase, extending into the early chronic phase. This prolonged COVID-19 pathology is often referred to as ‘Long COVID’. Simultaneously, case investigations have shown that COVID-19 individuals might have a variety of neurological problems. The accurate and accessible assessment of cognitive function in patients post-COVID-19 infection is thus of increasingly high importance for both public and individual health. Little is known about the influence of COVID-19 on the general cognitive levels but more importantly, at sub-functions level. Therefore, we first aim to summarize the current level of evidence supporting the negative impact of COVID-19 infection on cognitive functions. Twenty-seven studies were included in the systematic review representing a total of 94,103 participants (90,317 COVID-19 patients and 3786 healthy controls). We then performed a meta-analysis summarizing the results of five studies (959 participants, 513 patients) to quantify the impact of COVID-19 on cognitive functions. The overall effect, expressed in standardized mean differences, is −0.41 [95%CI −0.55; −0.27]. To prevent disability, we finally discuss the different approaches available in rehabilitation to help these patients and avoid long-term complications.

Suggested Citation

  • Sarah Houben & Bruno Bonnechère, 2022. "The Impact of COVID-19 Infection on Cognitive Function and the Implication for Rehabilitation: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(13), pages 1-21, June.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:13:p:7748-:d:846725
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    1. Amaya Jimeno-Almazán & Jesús G. Pallarés & Ángel Buendía-Romero & Alejandro Martínez-Cava & Francisco Franco-López & Bernardino J. Sánchez-Alcaraz Martínez & Enrique Bernal-Morel & Javier Courel-Ibáñe, 2021. "Post-COVID-19 Syndrome and the Potential Benefits of Exercise," IJERPH, MDPI, vol. 18(10), pages 1-16, May.
    2. Stefania Fugazzaro & Angela Contri & Otmen Esseroukh & Shaniko Kaleci & Stefania Croci & Marco Massari & Nicola Cosimo Facciolongo & Giulia Besutti & Mauro Iori & Carlo Salvarani & Stefania Costi, 2022. "Rehabilitation Interventions for Post-Acute COVID-19 Syndrome: A Systematic Review," IJERPH, MDPI, vol. 19(9), pages 1-24, April.
    3. Pavani Rangachari & Swapandeep S. Mushiana & Krista Herbert, 2021. "A Narrative Review of Factors Historically Influencing Telehealth Use across Six Medical Specialties in the United States," IJERPH, MDPI, vol. 18(9), pages 1-25, May.
    4. Callard, Felicity & Perego, Elisa, 2021. "How and why patients made Long Covid," Social Science & Medicine, Elsevier, vol. 268(C).
    5. Yirui Ma & Jie Deng & Qiao Liu & Min Du & Min Liu & Jue Liu, 2022. "Long-Term Consequences of COVID-19 at 6 Months and Above: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(11), pages 1-16, June.
    6. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
    7. Olivier Van Hove & Alexis Gillet & Jérôme Tack & Gregory Reychler & Magda Guatteri & Asuncion Ballarin & Justine Thomas & Rolando Espinoza & Frédéric Bonnier & Michelle Norrenberg & Pauline Daniel & M, 2022. "Development of a Medium Care Unit Using an Inexperienced Respiratory Staff: Lessons Learned during the COVID-19 Pandemic," IJERPH, MDPI, vol. 19(12), pages 1-13, June.
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    1. Nawar Diar Bakerly & Nikki Smith & Julie L. Darbyshire & Joseph Kwon & Emily Bullock & Sareeta Baley & Manoj Sivan & Brendan Delaney, 2024. "Pathophysiological Mechanisms in Long COVID: A Mixed Method Systematic Review," IJERPH, MDPI, vol. 21(4), pages 1-23, April.

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