IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i15p9027-d870871.html
   My bibliography  Save this article

European Epidemiological Patterns of Cannabis- and Substance-Related Body Wall Congenital Anomalies: Geospatiotemporal and Causal Inferential Study

Author

Listed:
  • Albert Stuart Reece

    (Division of Psychiatry, University of Western Australia, Crawley, WA 6009, Australia
    School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia)

  • Gary Kenneth Hulse

    (Division of Psychiatry, University of Western Australia, Crawley, WA 6009, Australia
    School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia)

Abstract

As body wall congenital anomalies (BWCAs) have a long history of being associated with prenatal or community cannabis exposure (CCE), it was of interest to investigate these epidemiological relationships in Europe given the recent increases in cannabis use prevalence, daily intensity, and Δ9-tetrahydrocannabinol (THC) potency. Methods: This study makes use of BWCA data from Eurocat, drug exposure data from the European Monitoring Centre for Drugs and Drug Addiction, and income from the World Bank. Results: The mapping analysis showed that BWCARs increased in France, Spain, and the Netherlands. The bivariate mapping analysis showed that the BWCA rates (BWCAR) and the cannabis resin THC concentration rose simultaneously in France, the Netherlands, Bulgaria, Sweden, and Norway. The bivariate ranking of the BWCARs by median minimum E-value (mEV) was omphalocele > diaphragmatic hernia > abdominal wall defects > gastroschisis. With inverse probability weighted multivariable panel regression, the series of BWCAs, including gastroschisis, omphalocele, and diaphragmatic hernia, was positively related to various metrics of cannabis use from p = 2.45 × 10 −14 , 4.77 × 10 −7 and <2.2 × 10 −16 . With geospatial regression, the same series of BWCAs was related to cannabis metrics from p = 0.0016, 5.28 × 10 −6 and 4.88 × 10 −9 . Seventeen out of twenty-eight (60.7%) of the E-value estimates were >9 (high range), as were 14/28 (50.0%) of the mEVs. Conclusion: The data confirm the close relationship of the BWCARs with the metrics of CCE, fulfill the quantitative criteria of causal inference, and underscore the salience of the public health impacts of cannabinoid teratogenicity. Of major concern is the rising CCE impacting exponential cannabinoid genotoxic dose-response relationships. CCE should be carefully restricted to protect the food chain, the genome, and the epigenome of coming generations.

Suggested Citation

  • Albert Stuart Reece & Gary Kenneth Hulse, 2022. "European Epidemiological Patterns of Cannabis- and Substance-Related Body Wall Congenital Anomalies: Geospatiotemporal and Causal Inferential Study," IJERPH, MDPI, vol. 19(15), pages 1-38, July.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:15:p:9027-:d:870871
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/15/9027/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/15/9027/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Millo, Giovanni & Piras, Gianfranco, 2012. "splm: Spatial Panel Data Models in R," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 47(i01).
    2. Wright, Marvin N. & Ziegler, Andreas, 2017. "ranger: A Fast Implementation of Random Forests for High Dimensional Data in C++ and R," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 77(i01).
    3. van der Wal, Willem M. & Geskus, Ronald B., 2011. "ipw: An R Package for Inverse Probability Weighting," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 43(i13).
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Albert Stuart Reece & Gary Kenneth Hulse, 2022. "Epidemiological Patterns of Cannabis- and Substance- Related Congenital Uronephrological Anomalies in Europe: Geospatiotemporal and Causal Inferential Study," IJERPH, MDPI, vol. 19(21), pages 1-61, October.
    2. Albert Stuart Reece & Gary Kenneth Hulse, 2023. "Clinical Epigenomic Explanation of the Epidemiology of Cannabinoid Genotoxicity Manifesting as Transgenerational Teratogenesis, Cancerogenesis and Aging Acceleration," IJERPH, MDPI, vol. 20(4), pages 1-24, February.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Albert Stuart Reece & Gary Kenneth Hulse, 2022. "European Epidemiological Patterns of Cannabis- and Substance-Related Congenital Neurological Anomalies: Geospatiotemporal and Causal Inferential Study," IJERPH, MDPI, vol. 20(1), pages 1-35, December.
    2. Albert Stuart Reece & Gary Kenneth Hulse, 2022. "Cannabis- and Substance-Related Epidemiological Patterns of Chromosomal Congenital Anomalies in Europe: Geospatiotemporal and Causal Inferential Study," IJERPH, MDPI, vol. 19(18), pages 1-51, September.
    3. Albert Stuart Reece & Gary Kenneth Hulse, 2022. "Epidemiological Patterns of Cannabis- and Substance- Related Congenital Uronephrological Anomalies in Europe: Geospatiotemporal and Causal Inferential Study," IJERPH, MDPI, vol. 19(21), pages 1-61, October.
    4. Albert Stuart Reece & Gary Kenneth Hulse, 2022. "Socioeconomic, Ethnocultural, Substance- and Cannabinoid-Related Epidemiology of Down Syndrome USA 1986–2016: Combined Geotemporospatial and Causal Inference Investigation," IJERPH, MDPI, vol. 19(20), pages 1-37, October.
    5. Albert Stuart Reece & Gary Kenneth Hulse, 2022. "State Trends of Cannabis Liberalization as a Causal Driver of Increasing Testicular Cancer Rates across the USA," IJERPH, MDPI, vol. 19(19), pages 1-37, October.
    6. Backer, David & Billing, Trey, 2024. "Forecasting the prevalence of child acute malnutrition using environmental and conflict conditions as leading indicators," World Development, Elsevier, vol. 176(C).
    7. Eleftheria Kontou & Noreen McDonald, 2021. "Associating ridesourcing with road safety outcomes: Insights from Austin, Texas," PLOS ONE, Public Library of Science, vol. 16(3), pages 1-18, March.
    8. Mariana Oliveira & Luís Torgo & Vítor Santos Costa, 2021. "Evaluation Procedures for Forecasting with Spatiotemporal Data," Mathematics, MDPI, vol. 9(6), pages 1-27, March.
    9. Baltagi, Badi H. & Yen, Yin-Fang, 2014. "Hospital treatment rates and spillover effects: Does ownership matter?," Regional Science and Urban Economics, Elsevier, vol. 49(C), pages 193-202.
    10. Álvarez, Inmaculada C. & Barbero, Javier & Zofío, José L., 2016. "A spatial autoregressive panel model to analyze road network spillovers on production," Transportation Research Part A: Policy and Practice, Elsevier, vol. 93(C), pages 83-92.
    11. Meyer, Maximilian & Hulke, Carolin & Kamwi, Jonathan & Kolem, Hannah & Börner, Jan, 2022. "Spatially heterogeneous effects of collective action on environmental dependence in Namibia’s Zambezi region," World Development, Elsevier, vol. 159(C).
    12. Agarwal, Sumit & Satyanarain, Rengarajan & Sing, Tien Foo & Vollmer, Derek, 2016. "Effects of construction activities on residential electricity consumption: Evidence from Singapore's public housing estates," Energy Economics, Elsevier, vol. 55(C), pages 101-111.
    13. Jiang, Wenhao & Stickley, Andrew & Ueda, Michiko, 2021. "Green space and suicide mortality in Japan: An ecological study," Social Science & Medicine, Elsevier, vol. 282(C).
    14. Frank Davenport, 2017. "Estimating standard errors in spatial panel models with time varying spatial correlation," Papers in Regional Science, Wiley Blackwell, vol. 96, pages 155-177, March.
    15. Marzieh Ronaghi & Michael Reed & Sayed Saghaian, 2020. "The impact of economic factors and governance on greenhouse gas emission," Environmental Economics and Policy Studies, Springer;Society for Environmental Economics and Policy Studies - SEEPS, vol. 22(2), pages 153-172, April.
    16. Waverly Wei & Maya Petersen & Mark J van der Laan & Zeyu Zheng & Chong Wu & Jingshen Wang, 2023. "Efficient targeted learning of heterogeneous treatment effects for multiple subgroups," Biometrics, The International Biometric Society, vol. 79(3), pages 1934-1946, September.
    17. Fang Di & Richards Timothy J. & Grebitus Carola, 2019. "Modeling Product Choices in a Peer Network," Forum for Health Economics & Policy, De Gruyter, vol. 22(1), pages 1-13, June.
    18. Bokelmann, Björn & Lessmann, Stefan, 2024. "Improving uplift model evaluation on randomized controlled trial data," European Journal of Operational Research, Elsevier, vol. 313(2), pages 691-707.
    19. Joel Podgorski & Oliver Kracht & Luis Araguas-Araguas & Stefan Terzer-Wassmuth & Jodie Miller & Ralf Straub & Rolf Kipfer & Michael Berg, 2024. "Groundwater vulnerability to pollution in Africa’s Sahel region," Nature Sustainability, Nature, vol. 7(5), pages 558-567, May.
    20. Emediegwu, Lotanna E. & Wossink, Ada & Hall, Alastair, 2022. "The impacts of climate change on agriculture in sub-Saharan Africa: A spatial panel data approach," World Development, Elsevier, vol. 158(C).

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:15:p:9027-:d:870871. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.