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Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours

Author

Listed:
  • Xiaotu Ma

    (Computational Biology, St Jude Children’s Research Hospital)

  • Yu Liu

    (Computational Biology, St Jude Children’s Research Hospital)

  • Yanling Liu

    (Computational Biology, St Jude Children’s Research Hospital)

  • Ludmil B. Alexandrov

    (University of California, San Diego)

  • Michael N. Edmonson

    (Computational Biology, St Jude Children’s Research Hospital)

  • Charles Gawad

    (Computational Biology, St Jude Children’s Research Hospital)

  • Xin Zhou

    (Computational Biology, St Jude Children’s Research Hospital)

  • Yongjin Li

    (Computational Biology, St Jude Children’s Research Hospital)

  • Michael C. Rusch

    (Computational Biology, St Jude Children’s Research Hospital)

  • John Easton

    (Computational Biology, St Jude Children’s Research Hospital)

  • Robert Huether

    (Independent Researcher
    Tempus Labs Inc.)

  • Veronica Gonzalez-Pena

    (Oncology, St Jude Children’s Research Hospital)

  • Mark R. Wilkinson

    (Computational Biology, St Jude Children’s Research Hospital)

  • Leandro C. Hermida

    (Office of Cancer Genomics, National Cancer Institute)

  • Sean Davis

    (Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH)

  • Edgar Sioson

    (Computational Biology, St Jude Children’s Research Hospital)

  • Stanley Pounds

    (St Jude Children’s Research Hospital)

  • Xueyuan Cao

    (St Jude Children’s Research Hospital)

  • Rhonda E. Ries

    (Fred Hutchinson Cancer Research Center, Seattle)

  • Zhaoming Wang

    (Computational Biology, St Jude Children’s Research Hospital)

  • Xiang Chen

    (Computational Biology, St Jude Children’s Research Hospital)

  • Li Dong

    (Computational Biology, St Jude Children’s Research Hospital)

  • Sharon J. Diskin

    (Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania)

  • Malcolm A. Smith

    (Cancer Therapy Evaluation Program, National Cancer Institute)

  • Jaime M. Guidry Auvil

    (Office of Cancer Genomics, National Cancer Institute)

  • Paul S. Meltzer

    (Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH)

  • Ching C. Lau

    (Connecticut Children’s Medical Center
    The Jackson Laboratory for Genomic Medicine)

  • Elizabeth J. Perlman

    (Ann & Robert H. Lurie Children’s Hospital of Chicago, Robert H. Lurie Cancer Center, Northwestern University)

  • John M. Maris

    (Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania)

  • Soheil Meshinchi

    (Fred Hutchinson Cancer Research Center, Seattle)

  • Stephen P. Hunger

    (Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania)

  • Daniela S. Gerhard

    (Office of Cancer Genomics, National Cancer Institute)

  • Jinghui Zhang

    (Computational Biology, St Jude Children’s Research Hospital)

Abstract

Analysis of the genomes, exomes and transcriptomes of 1,699 childhood cancers identifies 142 driver genes.

Suggested Citation

  • Xiaotu Ma & Yu Liu & Yanling Liu & Ludmil B. Alexandrov & Michael N. Edmonson & Charles Gawad & Xin Zhou & Yongjin Li & Michael C. Rusch & John Easton & Robert Huether & Veronica Gonzalez-Pena & Mark , 2018. "Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours," Nature, Nature, vol. 555(7696), pages 371-376, March.
    • Handle: RePEc:nat:nature:v:555:y:2018:i:7696:d:10.1038_nature25795
    DOI: 10.1038/nature25795
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    Cited by:

    1. Albert Stuart Reece & Gary Kenneth Hulse, 2022. "Epidemiology of Δ8THC-Related Carcinogenesis in USA: A Panel Regression and Causal Inferential Study," IJERPH, MDPI, vol. 19(13), pages 1-27, June.
    2. Ingrid M. Saldana-Guerrero & Luis F. Montano-Gutierrez & Katy Boswell & Christoph Hafemeister & Evon Poon & Lisa E. Shaw & Dylan Stavish & Rebecca A. Lea & Sara Wernig-Zorc & Eva Bozsaky & Irfete S. F, 2024. "A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations," Nature Communications, Nature, vol. 15(1), pages 1-25, December.
    3. David Wang & Mathieu Quesnel-Vallieres & San Jewell & Moein Elzubeir & Kristen Lynch & Andrei Thomas-Tikhonenko & Yoseph Barash, 2023. "A Bayesian model for unsupervised detection of RNA splicing based subtypes in cancers," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Eleanor L. Woodward & Minjun Yang & Larissa H. Moura-Castro & Hilda Bos & Rebeqa Gunnarsson & Linda Olsson-Arvidsson & Diana C. J. Spierings & Anders Castor & Nicolas Duployez & Marketa Zaliova & Jan , 2023. "Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    5. Ting Liu & Jianan Rao & Wenting Hu & Bowen Cui & Jiaoyang Cai & Yuhan Liu & Huiying Sun & Xiaoxiao Chen & Yanjing Tang & Jing Chen & Xiang Wang & Han Wang & Wubin Qian & Binchen Mao & Sheng Guo & Rong, 2022. "Distinct genomic landscape of Chinese pediatric acute myeloid leukemia impacts clinical risk classification," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    6. Xinran Dong & Liang Ding & Andrew Thrasher & Xinge Wang & Jingjing Liu & Qingfei Pan & Jordan Rash & Yogesh Dhungana & Xu Yang & Isabel Risch & Yuxin Li & Lei Yan & Michael Rusch & Clay McLeod & Koon-, 2023. "NetBID2 provides comprehensive hidden driver analysis," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    7. Lele Song & Qinglan Li & Lingbo Xia & Arushi Eesha Sahay & Qi Qiu & Yuanyuan Li & Haitao Li & Kotaro Sasaki & Katalin Susztak & Hao Wu & Liling Wan, 2024. "Single-cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape," Nature Communications, Nature, vol. 15(1), pages 1-26, December.
    8. Amanda C. Lorentzian & Jenna Rever & Enes K. Ergin & Meiyun Guo & Neha M. Akella & Nina Rolf & C. James Lim & Gregor S. D. Reid & Christopher A. Maxwell & Philipp F. Lange, 2023. "Targetable lesions and proteomes predict therapy sensitivity through disease evolution in pediatric acute lymphoblastic leukemia," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    9. Hope Mumme & Beena E. Thomas & Swati S. Bhasin & Upaasana Krishnan & Bhakti Dwivedi & Pruthvi Perumalla & Debasree Sarkar & Gulay B. Ulukaya & Himalee S. Sabnis & Sunita I. Park & Deborah DeRyckere & , 2023. "Single-cell analysis reveals altered tumor microenvironments of relapse- and remission-associated pediatric acute myeloid leukemia," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    10. Ulrik Kristoffer Stoltze & Jon Foss-Skiftesvik & Thomas van Overeem Hansen & Simon Rasmussen & Konrad J. Karczewski & Karin A. W. Wadt & Kjeld Schmiegelow, 2024. "The evolutionary impact of childhood cancer on the human gene pool," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    11. Han Wang & Huiying Sun & Bilin Liang & Fang Zhang & Fan Yang & Bowen Cui & Lixia Ding & Xiang Wang & Ronghua Wang & Jiaoyang Cai & Yanjing Tang & Jianan Rao & Wenting Hu & Shuang Zhao & Wenyan Wu & Xi, 2023. "Chromatin accessibility landscape of relapsed pediatric B-lineage acute lymphoblastic leukemia," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    12. Marco Bolis & Daniela Bossi & Arianna Vallerga & Valentina Ceserani & Manuela Cavalli & Daniela Impellizzieri & Laura Di Rito & Eugenio Zoni & Simone Mosole & Angela Rita Elia & Andrea Rinaldi & Ricar, 2021. "Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    13. Suzanne J. Forrest & Hersh Gupta & Abigail Ward & Yvonne Y. Li & Duong Doan & Alyaa Al-Ibraheemi & Sanda Alexandrescu & Pratiti Bandopadhayay & Suzanne Shusterman & Elizabeth A. Mullen & Natalie B. Co, 2024. "Molecular profiling of 888 pediatric tumors informs future precision trials and data-sharing initiatives in pediatric cancer," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    14. Dominik Laubscher & Berkley E. Gryder & Benjamin D. Sunkel & Thorkell Andresson & Marco Wachtel & Sudipto Das & Bernd Roschitzki & Witold Wolski & Xiaoli S. Wu & Hsien-Chao Chou & Young K. Song & Chao, 2021. "BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    15. Min Pan & William C. Wright & Richard H. Chapple & Asif Zubair & Manbir Sandhu & Jake E. Batchelder & Brandt C. Huddle & Jonathan Low & Kaley B. Blankenship & Yingzhe Wang & Brittney Gordon & Payton A, 2021. "The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma," Nature Communications, Nature, vol. 12(1), pages 1-20, December.
    16. Yanling Liu & Jonathon Klein & Richa Bajpai & Li Dong & Quang Tran & Pandurang Kolekar & Jenny L. Smith & Rhonda E. Ries & Benjamin J. Huang & Yi-Cheng Wang & Todd A. Alonzo & Liqing Tian & Heather L., 2023. "Etiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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