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A cannabinoid link between mitochondria and memory

Author

Listed:
  • Etienne Hebert-Chatelain

    (INSERM U1215, NeuroCentre Magendie
    Université de Bordeaux, NeuroCentre Magendie
    Université de Moncton)

  • Tifany Desprez

    (INSERM U1215, NeuroCentre Magendie
    Université de Bordeaux, NeuroCentre Magendie)

  • Román Serrat

    (INSERM U1215, NeuroCentre Magendie
    Université de Bordeaux, NeuroCentre Magendie)

  • Luigi Bellocchio

    (INSERM U1215, NeuroCentre Magendie
    Université de Bordeaux, NeuroCentre Magendie
    Complutense University)

  • Edgar Soria-Gomez

    (INSERM U1215, NeuroCentre Magendie
    Université de Bordeaux, NeuroCentre Magendie)

  • Arnau Busquets-Garcia

    (INSERM U1215, NeuroCentre Magendie
    Université de Bordeaux, NeuroCentre Magendie)

  • Antonio Christian Pagano Zottola

    (INSERM U1215, NeuroCentre Magendie
    Université de Bordeaux, NeuroCentre Magendie)

  • Anna Delamarre

    (INSERM U1215, NeuroCentre Magendie
    Université de Bordeaux, NeuroCentre Magendie)

  • Astrid Cannich

    (INSERM U1215, NeuroCentre Magendie
    Université de Bordeaux, NeuroCentre Magendie)

  • Peggy Vincent

    (INSERM U1215, NeuroCentre Magendie
    Université de Bordeaux, NeuroCentre Magendie)

  • Marjorie Varilh

    (INSERM U1215, NeuroCentre Magendie
    Université de Bordeaux, NeuroCentre Magendie)

  • Laurie M. Robin

    (INSERM U1215, NeuroCentre Magendie
    Université de Bordeaux, NeuroCentre Magendie)

  • Geoffrey Terral

    (INSERM U1215, NeuroCentre Magendie
    Université de Bordeaux, NeuroCentre Magendie)

  • M. Dolores García-Fernández

    (IMG Pharma Biotech S.L.
    Faculty of Medicine and Dentistry, University of the Basque Country UPV/EHU)

  • Michelangelo Colavita

    (INSERM U1215, NeuroCentre Magendie
    Université de Bordeaux, NeuroCentre Magendie
    Section of Pharmacology, University of Catania)

  • Wilfrid Mazier

    (INSERM U1215, NeuroCentre Magendie
    Université de Bordeaux, NeuroCentre Magendie)

  • Filippo Drago

    (Section of Pharmacology, University of Catania)

  • Nagore Puente

    (Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU
    Achucarro Basque Center for Neuroscience, Bizkaia Science and Technology Park)

  • Leire Reguero

    (Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU
    Achucarro Basque Center for Neuroscience, Bizkaia Science and Technology Park)

  • Izaskun Elezgarai

    (Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU
    Achucarro Basque Center for Neuroscience, Bizkaia Science and Technology Park)

  • Jean-William Dupuy

    (Université de Bordeaux, Centre Génomique Fonctionnelle)

  • Daniela Cota

    (INSERM U1215, NeuroCentre Magendie
    Université de Bordeaux, NeuroCentre Magendie)

  • Maria-Luz Lopez-Rodriguez

    (Complutense University)

  • Gabriel Barreda-Gómez

    (IMG Pharma Biotech S.L.)

  • Federico Massa

    (INSERM U1215, NeuroCentre Magendie
    Université de Bordeaux, NeuroCentre Magendie)

  • Pedro Grandes

    (Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU
    Achucarro Basque Center for Neuroscience, Bizkaia Science and Technology Park
    University of Victoria)

  • Giovanni Bénard

    (INSERM U1215, NeuroCentre Magendie
    Université de Bordeaux, NeuroCentre Magendie)

  • Giovanni Marsicano

    (INSERM U1215, NeuroCentre Magendie
    Université de Bordeaux, NeuroCentre Magendie)

Abstract

Cannabinoids affect CB1 receptors on the mitochondrial membranes in the brain, triggering a decrease in downstream cAMP-dependent signalling; this leads to a decrease in brain mitochondrial activity and to cannabinoid-induced amnesia.

Suggested Citation

  • Etienne Hebert-Chatelain & Tifany Desprez & Román Serrat & Luigi Bellocchio & Edgar Soria-Gomez & Arnau Busquets-Garcia & Antonio Christian Pagano Zottola & Anna Delamarre & Astrid Cannich & Peggy Vin, 2016. "A cannabinoid link between mitochondria and memory," Nature, Nature, vol. 539(7630), pages 555-559, November.
    • Handle: RePEc:nat:nature:v:539:y:2016:i:7630:d:10.1038_nature20127
    DOI: 10.1038/nature20127
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    Citations

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    Cited by:

    1. Paula Gómez-Sotres & Urszula Skupio & Tommaso Dalla Tor & Francisca Julio-Kalajzic & Astrid Cannich & Doriane Gisquet & Itziar Bonilla-Del Rio & Filippo Drago & Nagore Puente & Pedro Grandes & Luigi B, 2024. "Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Albert Stuart Reece & Gary Kenneth Hulse, 2023. "Clinical Epigenomic Explanation of the Epidemiology of Cannabinoid Genotoxicity Manifesting as Transgenerational Teratogenesis, Cancerogenesis and Aging Acceleration," IJERPH, MDPI, vol. 20(4), pages 1-24, February.
    3. Albert Stuart Reece & Gary Kenneth Hulse, 2022. "Epidemiology of Δ8THC-Related Carcinogenesis in USA: A Panel Regression and Causal Inferential Study," IJERPH, MDPI, vol. 19(13), pages 1-27, June.
    4. Albert Stuart Reece & Gary Kenneth Hulse, 2022. "Epigenomic and Other Evidence for Cannabis-Induced Aging Contextualized in a Synthetic Epidemiologic Overview of Cannabinoid-Related Teratogenesis and Cannabinoid-Related Carcinogenesis," IJERPH, MDPI, vol. 19(24), pages 1-57, December.
    5. Ignacio Fernández-Moncada & Gianluca Lavanco & Unai B. Fundazuri & Nasrin Bollmohr & Sarah Mountadem & Tommaso Dalla Tor & Pauline Hachaguer & Francisca Julio-Kalajzic & Doriane Gisquet & Roman Serrat, 2024. "A lactate-dependent shift of glycolysis mediates synaptic and cognitive processes in male mice," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    6. Albert Stuart Reece & Gary Kenneth Hulse, 2022. "State Trends of Cannabis Liberalization as a Causal Driver of Increasing Testicular Cancer Rates across the USA," IJERPH, MDPI, vol. 19(19), pages 1-37, October.

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