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The Effects of Childhood Maltreatment on Non-Suicidal Self-Injury in Male Adolescents: The Moderating Roles of the Monoamine Oxidase A (MAOA) Gene and the Catechol-O-Methyltransferase (COMT) Gene

Author

Listed:
  • Yemiao Gao

    (Institute of Developmental Psychology, Beijing Normal University, Beijing 100875, China)

  • Yuke Xiong

    (Institute of Developmental Psychology, Beijing Normal University, Beijing 100875, China)

  • Xia Liu

    (Institute of Developmental Psychology, Beijing Normal University, Beijing 100875, China)

  • Hui Wang

    (Institute of Developmental Psychology, Beijing Normal University, Beijing 100875, China)

Abstract

(1) Background: Numerous studies suggest strong associations between childhood maltreatment and nonsuicidal self-injury (NSSI); this is also true for the roles of dopaminergic genes in the etiology of some psychopathologies related to NSSI. Investigating the interactions of environments and genes is important in order to better understand the etiology of NSSI. (2) Methods: Within a sample of 269 Chinese male adolescents ( M age = 14.72, SD = 0.92), childhood maltreatment and NSSI were evaluated, and saliva samples were collected for MAOA T941G and COMT Val158Met polymorphism analyses. (3) Results: The results revealed no primary effects attributable to MAOA T941G and COMT Val158Met polymorphism on NSSI. However, there was a significant three-way interaction between MAOA, COMT, and child abuse (β = −0.34, p < 0.01) in adolescent NSSI. Except for carriers of the T allele of MAOA and the Met allele of COMT, all studied male adolescents displayed higher NSSI scores when exposed to a higher level of child abuse. A similar three-way interaction was not observed in the case of child neglect. (4) Conclusions: The results indicate that the MAOA gene and COMT gene play moderating roles in the association between child abuse and NSSI of male adolescents and suggest the polygenic underpinnings of NSSI.

Suggested Citation

  • Yemiao Gao & Yuke Xiong & Xia Liu & Hui Wang, 2021. "The Effects of Childhood Maltreatment on Non-Suicidal Self-Injury in Male Adolescents: The Moderating Roles of the Monoamine Oxidase A (MAOA) Gene and the Catechol-O-Methyltransferase (COMT) Gene," IJERPH, MDPI, vol. 18(5), pages 1-13, March.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:5:p:2598-:d:511015
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    References listed on IDEAS

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    1. Janaína C. N. Carvalho & Júlia C. Donat & Alice E. Brunnet & Thiago G. Silva & Gustavo R. Silva & Christian H. Kristensen, 2016. "Cognitive, Neurobiological and Psychopathological Alterations Associated with Child Maltreatment: A Review of Systematic Reviews," Child Indicators Research, Springer;The International Society of Child Indicators (ISCI), vol. 9(2), pages 389-406, June.
    2. Laura Carrel & Huntington F. Willard, 2005. "X-inactivation profile reveals extensive variability in X-linked gene expression in females," Nature, Nature, vol. 434(7031), pages 400-404, March.
    3. Yueyue Zhou & Yiming Liang & Jin Cheng & Hao Zheng & Zhengkui Liu, 2019. "Child Maltreatment in Western China: Demographic Differences and Associations with Mental Health," IJERPH, MDPI, vol. 16(19), pages 1-14, September.
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