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Cord Blood Adipocytokines and Body Composition in Early Childhood: A Systematic Review and Meta-Analysis

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  • Christos Bagias

    (Division of Health Sciences, Department of Population Evidence and Technologies, Warwick Medical School, University of Warwick, Coventry CV7 7HL, UK
    Department of Endocrinology and Diabetes, University Hospital of Ioannina, 45500 Ioannina, Greece)

  • Nithya Sukumar

    (Division of Health Sciences, Department of Population Evidence and Technologies, Warwick Medical School, University of Warwick, Coventry CV7 7HL, UK
    Academic Department of Diabetes, Endocrinology and Metabolism, George Eliot Hospital NHS Trust, Nuneaton CV10 7DJ, UK)

  • Yonas Weldeselassie

    (Division of Health Sciences, Department of Population Evidence and Technologies, Warwick Medical School, University of Warwick, Coventry CV7 7HL, UK)

  • Oyinlola Oyebode

    (Division of Health Sciences, Department of Population Evidence and Technologies, Warwick Medical School, University of Warwick, Coventry CV7 7HL, UK)

  • Ponnusamy Saravanan

    (Division of Health Sciences, Department of Population Evidence and Technologies, Warwick Medical School, University of Warwick, Coventry CV7 7HL, UK
    Academic Department of Diabetes, Endocrinology and Metabolism, George Eliot Hospital NHS Trust, Nuneaton CV10 7DJ, UK)

Abstract

Childhood obesity is a growing epidemic. Early identification of high-risk groups will allow for the development of prevention strategies. Cord blood adipocytokines have been previously examined as biomarkers predicting future obesity. We conducted a systematic review looking at the association between cord blood leptin and adiponectin with adiposity up to 5 years of age. A literature review was performed between January 1994 and August 2020 using two bibliographic databases (Medline/Pubmed and EMBASE) and was registered on PROSPERO (CRD42017069024). Studies using skinfold thickness and direct methods of assessing body composition in full term neonates were considered. Partial correlation and multiple regression models were used to present the results. Meta-analysis was performed, were possible, using a random effects model. Cochran’s Q test was used to assess heterogeneity and I 2 statistics to calculate the percentage of variation across studies. The potential for publication bias was assessed using funnel plots. Data from 22 studies were retrieved and reviewed by two independent reviewers. Cord blood leptin was positively associated with adiposity at birth ( r = 0.487; 95% CI: 0.444, 0.531) but was inversely related to adiposity up to 3 years of age. The association was not sustained at 5 years. There was a weak positive association between adiponectin in cord blood and adiposity at birth ( r = 0.201; 95% CI: 0.125, 0.277). No correlation was found between cord blood adiponectin in young children, but data were limited. This review supports that cord blood leptin and adiponectin are associated with adiposity at birth. The results of this study provide insight into the role of adipocytokines at birth on future metabolic health and their potential use as risk stratification tools.

Suggested Citation

  • Christos Bagias & Nithya Sukumar & Yonas Weldeselassie & Oyinlola Oyebode & Ponnusamy Saravanan, 2021. "Cord Blood Adipocytokines and Body Composition in Early Childhood: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 18(4), pages 1-16, February.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:4:p:1897-:d:500193
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    References listed on IDEAS

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    2. Pelletier, D.L. & Frongillo Jr., E.A. & Habicht, J.-P., 1993. "Epidemiologic evidence for a potentiating effect of malnutrition on child mortality," American Journal of Public Health, American Public Health Association, vol. 83(8), pages 1130-1133.
    3. Jiali Wang & Rong Liu & Meredith Hawkins & Nir Barzilai & Luciano Rossetti, 1998. "A nutrient-sensing pathway regulates leptin gene expression in muscle and fat," Nature, Nature, vol. 393(6686), pages 684-688, June.
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