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Associations of Helicobacter pylori infection and peptic disease with diabetic mellitus: Results from a large population-based study

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  • Saeda Haj
  • Gabriel Chodick
  • Rotem Refaeli
  • Sophy Goren
  • Varda Shalev
  • Khitam Muhsen

Abstract

Background: Evidence is conflicting regarding the association between Helicobacter pylori infection and diabetes mellitus. The study objective was to examine associations of H. pylori infection, gastric ulcers and duodenal ulcers, with diabetes mellitus. Methods: This cross-sectional study was undertaken using coded data from the computerized database of Maccabi Health Services in Israel, on 147,936 individuals aged 25–95 years who underwent the urea breath test during 2002–2012. Multiple logistic regression models were conducted, while adjusting for known risk factors for diabetes mellitus. Results: A H. pylori positive test was recorded for 76,992 (52.0%) individuals and diabetes for 12,207 (8.3%). The prevalence of diabetes was similar in individuals with and without H. pylori infection, but this association was modified (P for heterogeneity 0.049) by body mass index (BMI): adjusted odds ratio (aOR) 1.16 (95% confidence intervals (CI) 1.04–1.29) in persons with BMI

Suggested Citation

  • Saeda Haj & Gabriel Chodick & Rotem Refaeli & Sophy Goren & Varda Shalev & Khitam Muhsen, 2017. "Associations of Helicobacter pylori infection and peptic disease with diabetic mellitus: Results from a large population-based study," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-13, August.
    • Handle: RePEc:plo:pone00:0183687
    DOI: 10.1371/journal.pone.0183687
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    1. André Bado & Sandrine Levasseur & Samir Attoub & Stéphanie Kermorgant & Jean-Pierre Laigneau & Marie-Noëlle Bortoluzzi & Laurent Moizo & Thérèse Lehy & Michèle Guerre-Millo & Yannick Le Marchand-Brust, 1998. "The stomach is a source of leptin," Nature, Nature, vol. 394(6695), pages 790-793, August.
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