IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v394y1998i6695d10.1038_29547.html
   My bibliography  Save this article

The stomach is a source of leptin

Author

Listed:
  • André Bado

    (Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 10, IFR2 Cellules Epithéliales, Hôpital Bichat)

  • Sandrine Levasseur

    (Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 10, IFR2 Cellules Epithéliales, Hôpital Bichat)

  • Samir Attoub

    (Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 10, IFR2 Cellules Epithéliales, Hôpital Bichat)

  • Stéphanie Kermorgant

    (Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 10, IFR2 Cellules Epithéliales, Hôpital Bichat)

  • Jean-Pierre Laigneau

    (Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 10, IFR2 Cellules Epithéliales, Hôpital Bichat)

  • Marie-Noëlle Bortoluzzi

    (INSERM U145, Faculté de Médecine)

  • Laurent Moizo

    (Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 10, IFR2 Cellules Epithéliales, Hôpital Bichat)

  • Thérèse Lehy

    (Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 10, IFR2 Cellules Epithéliales, Hôpital Bichat)

  • Michèle Guerre-Millo

    (INSERM U465, Institut des Cordeliers)

  • Yannick Le Marchand-Brustel

    (INSERM U145, Faculté de Médecine)

  • Miguel. J. M. Lewin

    (Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 10, IFR2 Cellules Epithéliales, Hôpital Bichat)

Abstract

The circulating peptide leptin, which is the product of the ob gene1, provides feedback information on the size of fat stores to central Ob receptors2,3 that control food intake and body-weight homeostasis4,5,6. Leptin has so far been reported to be secreted only by adipocytes1 and the placenta7. Here we show that leptin messenger RNA and leptin protein are present in rat gastric epithelium, and that cells in the glands of the gastric fundic mucosa are immunoreactive for leptin. The physiological function of this previously unsuspected source of leptin is unknown. However, both feeding and administration of CCK-8 (the biologically active carboxy-terminal end of cholecystokinin) result in a rapid and large decrease in both leptin cell immunoreactivity and the leptin content of the fundic epithelium, with a concomitant increase in the concentration of leptin in the plasma. These results indicate that gastric leptin may be involved in early CCK-mediated effects activated by food intake, possibly including satiety.

Suggested Citation

  • André Bado & Sandrine Levasseur & Samir Attoub & Stéphanie Kermorgant & Jean-Pierre Laigneau & Marie-Noëlle Bortoluzzi & Laurent Moizo & Thérèse Lehy & Michèle Guerre-Millo & Yannick Le Marchand-Brust, 1998. "The stomach is a source of leptin," Nature, Nature, vol. 394(6695), pages 790-793, August.
    • Handle: RePEc:nat:nature:v:394:y:1998:i:6695:d:10.1038_29547
    DOI: 10.1038/29547
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/29547
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/29547?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Saeda Haj & Gabriel Chodick & Rotem Refaeli & Sophy Goren & Varda Shalev & Khitam Muhsen, 2017. "Associations of Helicobacter pylori infection and peptic disease with diabetic mellitus: Results from a large population-based study," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-13, August.
    2. Maria Grazia Cappai & Sabine Aboling & Cecilia Dall’Aglio, 2021. "Beyond Digestion: Can Animals Shape the Landscape According to Their Species–Specific Salivary Secretions?," Agriculture, MDPI, vol. 11(9), pages 1-10, August.
    3. Xinlan Xu & Weide Li & Lan Qin & Wenjiao Yang & Guowei Yu & Qishan Wei, 2019. "Relationship between Helicobacter pylori infection and obesity in Chinese adults: A systematic review with meta-analysis," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-13, September.
    4. Christos Bagias & Nithya Sukumar & Yonas Weldeselassie & Oyinlola Oyebode & Ponnusamy Saravanan, 2021. "Cord Blood Adipocytokines and Body Composition in Early Childhood: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 18(4), pages 1-16, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:394:y:1998:i:6695:d:10.1038_29547. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.