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Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction

Author

Listed:
  • Stefania D’Angelo

    (Department of Movement Sciences and Wellbeing, University of Naples Parthenope, 80133 Napoli, Italy)

  • Elena Mele

    (Department of Movement Sciences and Wellbeing, University of Naples Parthenope, 80133 Napoli, Italy)

  • Federico Di Filippo

    (Deptartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, via Allende, 84081 Baronissi (SA), Italy)

  • Andrea Viggiano

    (Deptartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, via Allende, 84081 Baronissi (SA), Italy)

  • Rosaria Meccariello

    (Department of Movement Sciences and Wellbeing, University of Naples Parthenope, 80133 Napoli, Italy)

Abstract

Diet deeply impacts brain functions like synaptic plasticity and cognitive processes, neuroendocrine functions, reproduction and behaviour, with detrimental or protective effects on neuronal physiology and therefore consequences for health. In this respect, the activity of metabolic sensors within the brain is critical for the maintenance of health status and represents a possible therapeutic target for some diseases. This review summarizes the main activity of Sirtuin1 (Sirt1), a metabolic sensor within the brain with a focus on the link between the central control of energy homeostasis and reproduction. The possible modulation of Sirt1 by natural phytochemical compounds like polyphenols is also discussed.

Suggested Citation

  • Stefania D’Angelo & Elena Mele & Federico Di Filippo & Andrea Viggiano & Rosaria Meccariello, 2021. "Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction," IJERPH, MDPI, vol. 18(3), pages 1-17, January.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:3:p:1243-:d:490003
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    References listed on IDEAS

    as
    1. Maria Letizia Motti & Rosaria Meccariello, 2019. "Minireview: The Epigenetic Modulation of KISS1 in Reproduction and Cancer," IJERPH, MDPI, vol. 16(14), pages 1-9, July.
    2. Frédéric Picard & Martin Kurtev & Namjin Chung & Acharawan Topark-Ngarm & Thanaset Senawong & Rita Machado de Oliveira & Mark Leid & Michael W. McBurney & Leonard Guarente, 2004. "Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ," Nature, Nature, vol. 429(6993), pages 771-776, June.
    3. Frédéric Picard & Martin Kurtev & Namjin Chung & Acharawan Topark-Ngarm & Thanaset Senawong & Rita Machado de Oliveira & Mark Leid & Michael W. McBurney & Leonard Guarente, 2004. "Correction: Corrigendum: Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ," Nature, Nature, vol. 430(7002), pages 921-921, August.
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    Cited by:

    1. Filomena Mazzeo & Rosaria Meccariello, 2023. "Cannabis and Paternal Epigenetic Inheritance," IJERPH, MDPI, vol. 20(9), pages 1-14, April.
    2. Stefania D'Angelo & Rosaria Meccariello, 2021. "Microplastics: A Threat for Male Fertility," IJERPH, MDPI, vol. 18(5), pages 1-11, March.

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