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Minireview: The Epigenetic Modulation of KISS1 in Reproduction and Cancer

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  • Maria Letizia Motti

    (Dipartimento di Scienze Motorie e del Benessere, Università di Napoli Parthenope, via Medina 40, 80133 Napoli, Italy)

  • Rosaria Meccariello

    (Dipartimento di Scienze Motorie e del Benessere, Università di Napoli Parthenope, via Medina 40, 80133 Napoli, Italy)

Abstract

Epigenetics describes how both lifestyle and environment may affect human health through the modulation of genome functions and without any change to the DNA nucleotide sequence. The discovery of several epigenetic mechanisms and the possibility to deliver epigenetic marks in cells, gametes, and biological fluids has opened up new perspectives in the prevention, diagnosis, and treatment of human diseases. In this respect, the depth of knowledge of epigenetic mechanisms is fundamental to preserving health status and to developing targeted interventions. In this minireview, we summarize the epigenetic modulation of the KISS1 gene in order to provide an example of epigenetic regulation in health and disease.

Suggested Citation

  • Maria Letizia Motti & Rosaria Meccariello, 2019. "Minireview: The Epigenetic Modulation of KISS1 in Reproduction and Cancer," IJERPH, MDPI, vol. 16(14), pages 1-9, July.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:14:p:2607-:d:250583
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    1. S. C. Mack & H. Witt & R. M. Piro & L. Gu & S. Zuyderduyn & A. M. Stütz & X. Wang & M. Gallo & L. Garzia & K. Zayne & X. Zhang & V. Ramaswamy & N. Jäger & D. T. W. Jones & M. Sill & T. J. Pugh & M. Ry, 2014. "Epigenomic alterations define lethal CIMP-positive ependymomas of infancy," Nature, Nature, vol. 506(7489), pages 445-450, February.
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    Cited by:

    1. Stefania D’Angelo & Elena Mele & Federico Di Filippo & Andrea Viggiano & Rosaria Meccariello, 2021. "Sirt1 Activity in the Brain: Simultaneous Effects on Energy Homeostasis and Reproduction," IJERPH, MDPI, vol. 18(3), pages 1-17, January.
    2. Filomena Mazzeo & Rosaria Meccariello, 2023. "Cannabis and Paternal Epigenetic Inheritance," IJERPH, MDPI, vol. 20(9), pages 1-14, April.
    3. Stefania D'Angelo & Rosaria Meccariello, 2021. "Microplastics: A Threat for Male Fertility," IJERPH, MDPI, vol. 18(5), pages 1-11, March.

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      Keywords

      epigenetics; cancer; reproduction; KISS1 ; KISS1R;
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