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Sirt1 Inhibits Adipose Tissue Inflammation by Foxos/ mTOR/S6K1 Signal Pathway in Mice

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  • Bin Li

    (Institute of Animal Husbandry and Veterinary, Tibet Autonomous Regional Academy of Agricultural Sciences, Tibet 850000, China
    State Key Laboratory of Hulless Barley and Yak Germplasm Resources and Genetic Improvement, Lhasa, Tibet 850000, China)

Abstract

Sirtuin Type 1 (Sirt1) plays an important role in lipid metabolism and obesity. The overload calorie intake causes the imbalance between lipolysis and lipogenesis and leads to adipose tissue dysfunction. Moreover...

Suggested Citation

  • Bin Li, 2019. "Sirt1 Inhibits Adipose Tissue Inflammation by Foxos/ mTOR/S6K1 Signal Pathway in Mice," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 19(5), pages 14646-14655, July.
    • Handle: RePEc:abf:journl:v:19:y:2019:i:5:p:14646-14655
    DOI: 10.26717/BJSTR.2019.19.003371
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    References listed on IDEAS

    as
    1. Gökhan S. Hotamisligil, 2006. "Inflammation and metabolic disorders," Nature, Nature, vol. 444(7121), pages 860-867, December.
    2. Leonard Guarente, 2006. "Sirtuins as potential targets for metabolic syndrome," Nature, Nature, vol. 444(7121), pages 868-874, December.
    3. Frédéric Picard & Martin Kurtev & Namjin Chung & Acharawan Topark-Ngarm & Thanaset Senawong & Rita Machado de Oliveira & Mark Leid & Michael W. McBurney & Leonard Guarente, 2004. "Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ," Nature, Nature, vol. 429(6993), pages 771-776, June.
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