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Environmental Substances Associated with Alzheimer’s Disease—A Scoping Review

Author

Listed:
  • Hanna Maria Elonheimo

    (Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Mannerheimintie 166, 00271 Helsinki, Finland)

  • Helle Raun Andersen

    (Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, DK-5000 Odense C, Denmark
    Both authors equally contributed.)

  • Andromachi Katsonouri

    (Human Biomonitoring and Control of Industrial Products Laboratory, State General Laboratory, Ministry of Health, P.O. Box 28648, Nicosia 2081, Cyprus
    Both authors equally contributed.)

  • Hanna Tolonen

    (Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Mannerheimintie 166, 00271 Helsinki, Finland)

Abstract

Alzheimer’s disease (AD) is the most common form of dementia, prevalent in approximately 50–70% of the dementia cases. AD affects memory, and it is a progressive disease interfering with cognitive abilities, behaviour and functioning of the person affected. In 2015, there were 47 million people affected by dementia worldwide, and the figure was estimated to increase to 75 million in 2030 and to 132 million by 2050. In the framework of European Human Biomonitoring Initiative (HBM4EU), 18 substances or substance groups were prioritized for investigation. For each of the priority substances, a scoping document was prepared. Based on these scoping documents and complementary review of the recent literature, a scoping review of HBM4EU-priority substances which might be associated with AD was conducted. A possible association between risk of AD and pesticides was detected. For mercury (Hg), association is possible but inconsistent. Regarding cadmium (Cd) and arsenic (As), the results are inconsistent but inclined towards possible associations between the substances and the risk of disease. The evidence regarding lead (Pb) was weaker than for the other substances; however, possible associations exist. Although there is evidence of adverse neurological effects of environmental substances, more research is needed. Environmental chemical exposure and the related hazards are essential concerns for public health, and they could be preventable.

Suggested Citation

  • Hanna Maria Elonheimo & Helle Raun Andersen & Andromachi Katsonouri & Hanna Tolonen, 2021. "Environmental Substances Associated with Alzheimer’s Disease—A Scoping Review," IJERPH, MDPI, vol. 18(22), pages 1-22, November.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:22:p:11839-:d:677111
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    References listed on IDEAS

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    1. Robert Siblerud & Joachim Mutter & Elaine Moore & Johannes Naumann & Harald Walach, 2019. "A Hypothesis and Evidence That Mercury May be an Etiological Factor in Alzheimer’s Disease," IJERPH, MDPI, vol. 16(24), pages 1-15, December.
    2. Lars-Gunnar Gunnarsson & Lennart Bodin, 2019. "Occupational Exposures and Neurodegenerative Diseases—A Systematic Literature Review and Meta-Analyses," IJERPH, MDPI, vol. 16(3), pages 1-17, January.
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    1. Loreta Strumylaite & Rima Kregzdyte & Odeta Kucikiene & Dale Baranauskiene & Vaida Simakauskiene & Rima Naginiene & Gyte Damuleviciene & Vita Lesauskaite & Reda Zemaitiene, 2022. "Alzheimer’s Disease Association with Metals and Metalloids Concentration in Blood and Urine," IJERPH, MDPI, vol. 19(12), pages 1-11, June.

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