IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i22p11839-d677111.html
   My bibliography  Save this article

Environmental Substances Associated with Alzheimer’s Disease—A Scoping Review

Author

Listed:
  • Hanna Maria Elonheimo

    (Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Mannerheimintie 166, 00271 Helsinki, Finland)

  • Helle Raun Andersen

    (Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, DK-5000 Odense C, Denmark
    Both authors equally contributed.)

  • Andromachi Katsonouri

    (Human Biomonitoring and Control of Industrial Products Laboratory, State General Laboratory, Ministry of Health, P.O. Box 28648, Nicosia 2081, Cyprus
    Both authors equally contributed.)

  • Hanna Tolonen

    (Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Mannerheimintie 166, 00271 Helsinki, Finland)

Abstract

Alzheimer’s disease (AD) is the most common form of dementia, prevalent in approximately 50–70% of the dementia cases. AD affects memory, and it is a progressive disease interfering with cognitive abilities, behaviour and functioning of the person affected. In 2015, there were 47 million people affected by dementia worldwide, and the figure was estimated to increase to 75 million in 2030 and to 132 million by 2050. In the framework of European Human Biomonitoring Initiative (HBM4EU), 18 substances or substance groups were prioritized for investigation. For each of the priority substances, a scoping document was prepared. Based on these scoping documents and complementary review of the recent literature, a scoping review of HBM4EU-priority substances which might be associated with AD was conducted. A possible association between risk of AD and pesticides was detected. For mercury (Hg), association is possible but inconsistent. Regarding cadmium (Cd) and arsenic (As), the results are inconsistent but inclined towards possible associations between the substances and the risk of disease. The evidence regarding lead (Pb) was weaker than for the other substances; however, possible associations exist. Although there is evidence of adverse neurological effects of environmental substances, more research is needed. Environmental chemical exposure and the related hazards are essential concerns for public health, and they could be preventable.

Suggested Citation

  • Hanna Maria Elonheimo & Helle Raun Andersen & Andromachi Katsonouri & Hanna Tolonen, 2021. "Environmental Substances Associated with Alzheimer’s Disease—A Scoping Review," IJERPH, MDPI, vol. 18(22), pages 1-22, November.
  • Handle: RePEc:gam:jijerp:v:18:y:2021:i:22:p:11839-:d:677111
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/22/11839/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/18/22/11839/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Lars-Gunnar Gunnarsson & Lennart Bodin, 2019. "Occupational Exposures and Neurodegenerative Diseases—A Systematic Literature Review and Meta-Analyses," IJERPH, MDPI, vol. 16(3), pages 1-17, January.
    2. Robert Siblerud & Joachim Mutter & Elaine Moore & Johannes Naumann & Harald Walach, 2019. "A Hypothesis and Evidence That Mercury May be an Etiological Factor in Alzheimer’s Disease," IJERPH, MDPI, vol. 16(24), pages 1-15, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Loreta Strumylaite & Rima Kregzdyte & Odeta Kucikiene & Dale Baranauskiene & Vaida Simakauskiene & Rima Naginiene & Gyte Damuleviciene & Vita Lesauskaite & Reda Zemaitiene, 2022. "Alzheimer’s Disease Association with Metals and Metalloids Concentration in Blood and Urine," IJERPH, MDPI, vol. 19(12), pages 1-11, June.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Giorgia Adani & Tommaso Filippini & Caterina Garuti & Marcella Malavolti & Giulia Vinceti & Giovanna Zamboni & Manuela Tondelli & Chiara Galli & Manuela Costa & Marco Vinceti & Annalisa Chiari, 2020. "Environmental Risk Factors for Early-Onset Alzheimer’s Dementia and Frontotemporal Dementia: A Case-Control Study in Northern Italy," IJERPH, MDPI, vol. 17(21), pages 1-18, October.
    2. Joanna Wyszkowska & Colin Pritchard, 2022. "Open Questions on the Electromagnetic Field Contribution to the Risk of Neurodegenerative Diseases," IJERPH, MDPI, vol. 19(23), pages 1-15, December.
    3. Antonio Belmonte & Pilar Muñoz & Juan Santos-Echeandía & Diego Romero, 2021. "Tissue Distribution of Mercury and Its Relationship with Selenium in Atlantic Bluefin Tuna ( Thunnus thynnus L.)," IJERPH, MDPI, vol. 18(24), pages 1-16, December.
    4. Eirini Dimakakou & Helinor J. Johnston & George Streftaris & John W. Cherrie, 2020. "Is Environmental and Occupational Particulate Air Pollution Exposure Related to Type-2 Diabetes and Dementia? A Cross-Sectional Analysis of the UK Biobank," IJERPH, MDPI, vol. 17(24), pages 1-17, December.
    5. Jamila Alessandra Perini & Mayara Calixto Silva & Ana Claudia Santiago de Vasconcellos & Paulo Victor Sousa Viana & Marcelo Oliveira Lima & Iracina Maura Jesus & Joseph William Kempton & Rogério Adas , 2021. "Genetic Polymorphism of Delta Aminolevulinic Acid Dehydratase ( ALAD ) Gene and Symptoms of Chronic Mercury Exposure in Munduruku Indigenous Children within the Brazilian Amazon," IJERPH, MDPI, vol. 18(16), pages 1-12, August.
    6. Morgane Bresson & Mathilde Bureau & Jérémie Le Goff & Yannick Lecluse & Elsa Robelot & Justine Delamare & Isabelle Baldi & Pierre Lebailly, 2022. "Pesticide Exposure in Fruit-Growers: Comparing Levels and Determinants Assessed under Usual Conditions of Work (CANEPA Study) with Those Predicted by Registration Process (Agricultural Operator Exposu," IJERPH, MDPI, vol. 19(8), pages 1-20, April.
    7. Yuhui Zhang & Xiaohong Chen & Ling Xie, 2023. "Pleurotus pulmonarius Strain: Arsenic(III)/Cadmium(II) Accumulation, Tolerance, and Simulation Application in Environmental Remediation," IJERPH, MDPI, vol. 20(6), pages 1-12, March.
    8. Tommaso Filippini & Marina Tesauro & Maria Fiore & Carlotta Malagoli & Michela Consonni & Federica Violi & Laura Iacuzio & Elisa Arcolin & Gea Oliveri Conti & Antonio Cristaldi & Pietro Zuccarello & E, 2020. "Reply to Comment on “Environmental and Occupational Risk Factors of Amyotrophic Lateral Sclerosis: A Population-Based Case-Control Study”," IJERPH, MDPI, vol. 17(18), pages 1-3, September.
    9. Raphaëlle Teysseire & Emmanuelle Barron & Isabelle Baldi & Carole Bedos & Alexis Chazeaubeny & Karyn Le Menach & Audrey Roudil & Hélène Budzinski & Fleur Delva, 2023. "Pesticide Exposure of Residents Living in Wine Regions: Protocol and First Results of the Pestiprev Study," IJERPH, MDPI, vol. 20(5), pages 1-14, February.
    10. Tommaso Filippini & Jessica Mandrioli & Carlotta Malagoli & Sofia Costanzini & Andrea Cherubini & Giuseppe Maffeis & Marco Vinceti, 2021. "Risk of Amyotrophic Lateral Sclerosis and Exposure to Particulate Matter from Vehicular Traffic: A Case-Control Study," IJERPH, MDPI, vol. 18(3), pages 1-14, January.
    11. Isabella Karakis & Shaked Yarza & Yair Zlotnik & Gal Ifergane & Itai Kloog & Kineret Grant-Sasson & Lena Novack, 2023. "Contribution of Solar Radiation and Pollution to Parkinson’s Disease," IJERPH, MDPI, vol. 20(3), pages 1-18, January.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:22:p:11839-:d:677111. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.