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Bisphosphonate Use and Hospitalization for Hip Fractures in Women: An Observational Population-Based Study in France

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  • Bastien Bourrion

    (Institut Pierre-Louis d’Epidémiologie et de Santé Publique (IPLESP UMRS 1136), INSERM, Sorbonne Université, 75012 Paris, France
    Département de Médecine Générale, Faculté des Sciences de la Santé Simone Veil, Université Versailles-Saint-Quentin-en-Yvelines, 78180 Montigny le Bretonneux, France)

  • Cécile Souty

    (Institut Pierre-Louis d’Epidémiologie et de Santé Publique (IPLESP UMRS 1136), INSERM, Sorbonne Université, 75012 Paris, France)

  • Lucie Fournier

    (Institut Pierre-Louis d’Epidémiologie et de Santé Publique (IPLESP UMRS 1136), INSERM, Sorbonne Université, 75012 Paris, France)

  • Ana-Maria Vilcu

    (Institut Pierre-Louis d’Epidémiologie et de Santé Publique (IPLESP UMRS 1136), INSERM, Sorbonne Université, 75012 Paris, France)

  • Thierry Blanchon

    (Institut Pierre-Louis d’Epidémiologie et de Santé Publique (IPLESP UMRS 1136), INSERM, Sorbonne Université, 75012 Paris, France)

  • Pierre-Yves Böelle

    (Institut Pierre-Louis d’Epidémiologie et de Santé Publique (IPLESP UMRS 1136), INSERM, Sorbonne Université, 75012 Paris, France
    Service de Santé Publique, Hôpital Universitaire Saint-Antoine, AP-HP, 75012 Paris, France)

  • Thomas Hanslik

    (Institut Pierre-Louis d’Epidémiologie et de Santé Publique (IPLESP UMRS 1136), INSERM, Sorbonne Université, 75012 Paris, France
    Service de Médecine Interne, Hôpital Universitaire Ambroise-Paré, AP-HP, 92100 Boulogne-Billancourt, France
    Faculté des Sciences de la Santé Simone Veil, Université de Versailles Saint-Quentin-en-Yvelines, 78180 Montigny-le-Bretonneux, France)

  • Mathilde François

    (Institut Pierre-Louis d’Epidémiologie et de Santé Publique (IPLESP UMRS 1136), INSERM, Sorbonne Université, 75012 Paris, France
    Département de Médecine Générale, Faculté des Sciences de la Santé Simone Veil, Université Versailles-Saint-Quentin-en-Yvelines, 78180 Montigny le Bretonneux, France
    CESP, Bâtiment 15/16 Inserm, Hôpital Paul Brousse, 16 Avenue Paul Vaillant Couturier, INSERM, UVSQ, Université Paris-Saclay, 94807 Villejuif, France)

Abstract

Bisphosphonates are widely used in the treatment of women at risk of osteoporotic hip fracture; however, the overall effectiveness of bisphosphonates in the prevention of osteoporotic fractures has not been studied in real life. To investigate whether the use of bisphosphonates in women aged 50 years and over is associated with a decrease in hospitalization for osteoporotic hip fractures, a historical prospective cohort study was conducted between 2009 and 2016 from a permanent representative sample consisting of 1/97 of the French health insurance beneficiaries. Bisphosphonate use was defined according to medication persistence and adherence regarding bisphosphonate dispensations. The primary outcome was the hospitalization rate for osteoporotic hip fracture. Among the 81,268 women included, 2005 were exposed to bisphosphonates. The median time of bisphosphonate exposure was 12 (IQR, 3–29) and 17 (IQR, 5–42) months for the persistence and adherence definitions, respectively. Exposure to bisphosphonates was not associated with a decrease in hospitalization for hip fracture: weighted HRadherence = 0.66 (95% CI, 0.33 to 1.33); HRpersistance = 0.77 (95% CI, 0.38 to 1.57). In real life, bisphosphonate use does not appear to reduce hospitalization for hip fractures, as to date, it is probably prescribed as primary prevention and for a duration too short to be effective.

Suggested Citation

  • Bastien Bourrion & Cécile Souty & Lucie Fournier & Ana-Maria Vilcu & Thierry Blanchon & Pierre-Yves Böelle & Thomas Hanslik & Mathilde François, 2021. "Bisphosphonate Use and Hospitalization for Hip Fractures in Women: An Observational Population-Based Study in France," IJERPH, MDPI, vol. 18(16), pages 1-11, August.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:16:p:8780-:d:617982
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    References listed on IDEAS

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    1. van der Wal, Willem M. & Geskus, Ronald B., 2011. "ipw: An R Package for Inverse Probability Weighting," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 43(i13).
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