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The Influence of Traffic-Related Air Pollution (TRAP) in Primary Schools and Residential Proximity to Traffic Sources on Histone H3 Level in Selected Malaysian Children

Author

Listed:
  • Nur Faseeha Suhaimi

    (Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia)

  • Juliana Jalaludin

    (Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia
    Department of Occupational Health and Safety, Faculty of Public Health, Universitas Airlangga, Surabaya 60115, Indonesia)

  • Suhaili Abu Bakar

    (Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia)

Abstract

This study aimed to investigate the association between traffic-related air pollution (TRAP) exposure and histone H3 modification among school children in high-traffic (HT) and low-traffic (LT) areas in Malaysia. Respondents’ background information and personal exposure to traffic sources were obtained from questionnaires distributed to randomly selected school children. Real-time monitoring instruments were used for 6-h measurements of PM 10 , PM 2.5 , PM 1 , NO 2 , SO 2 , O 3 , CO, and total volatile organic compounds (TVOC). Meanwhile, 24-h measurements of PM 2.5 -bound black carbon (BC) were performed using air sampling pumps. The salivary histone H3 level was captured using an enzyme-linked immunosorbent assay (ELISA). HT schools had significantly higher PM 10 , PM 2.5 , PM 1 , BC, NO 2 , SO 2 , O 3 , CO, and TVOC than LT schools, all at p < 0.001. Children in the HT area were more likely to get higher histone H3 levels ( z = −5.13). There were positive weak correlations between histone H3 level and concentrations of NO 2 ( r = 0.37), CO ( r = 0.36), PM 1 ( r = 0.35), PM 2.5 ( r = 0.34), SO 2 ( r = 0.34), PM 10 ( r = 0.33), O 3 ( r = 0.33), TVOC ( r = 0.25), and BC ( r = 0.19). Overall, this study proposes the possible role of histone H3 modification in interpreting the effects of TRAP exposure via non-genotoxic mechanisms.

Suggested Citation

  • Nur Faseeha Suhaimi & Juliana Jalaludin & Suhaili Abu Bakar, 2021. "The Influence of Traffic-Related Air Pollution (TRAP) in Primary Schools and Residential Proximity to Traffic Sources on Histone H3 Level in Selected Malaysian Children," IJERPH, MDPI, vol. 18(15), pages 1-19, July.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:15:p:7995-:d:603422
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    References listed on IDEAS

    as
    1. Nor Ashikin Sopian & Juliana Jalaludin & Suhaili Abu Bakar & Titi Rahmawati Hamedon & Mohd Talib Latif, 2021. "Exposure to Particulate PAHs on Potential Genotoxicity and Cancer Risk among School Children Living Near the Petrochemical Industry," IJERPH, MDPI, vol. 18(5), pages 1-20, March.
    2. Omer Saud Azeez & Biswajeet Pradhan & Helmi Z. M. Shafri, 2018. "Vehicular CO Emission Prediction Using Support Vector Regression Model and GIS," Sustainability, MDPI, vol. 10(10), pages 1-18, September.
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    More about this item

    Keywords

    traffic-related air pollution; primary schools; vulnerable population; indoor air quality; histone H3;
    All these keywords.

    JEL classification:

    • H3 - Public Economics - - Fiscal Policies and Behavior of Economic Agents

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