IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i14p7607-d596068.html
   My bibliography  Save this article

A Multivariate Age-Structured Stochastic Model with Immunization Strategies to Describe Bronchiolitis Dynamics

Author

Listed:
  • Mónica López-Lacort

    (Vaccine Research Department, Fisabio-Public Health, Avda. Cataluña 21, 46020 Valencia, Spain)

  • Ana Corberán-Vallet

    (Department of Statistics and Operations Research, Universitat de València, Dr. Moliner 50, 46100 Burjassot, Spain)

  • Francisco J. Santonja Gómez

    (Department of Statistics and Operations Research, Universitat de València, Dr. Moliner 50, 46100 Burjassot, Spain)

Abstract

Bronchiolitis has a high morbidity in children under 2 years old. Respiratory syncytial virus (RSV) is the most common pathogen causing the disease. At present, there is only a costly humanized monoclonal RSV-specific antibody to prevent RSV. However, different immunization strategies are being developed. Hence, evaluation and comparison of their impact is important for policymakers. The analysis of the disease with a Bayesian stochastic compartmental model provided an improved and more natural description of its dynamics. However, the consideration of different age groups is still needed, since disease transmission greatly varies with age. In this work, we propose a multivariate age-structured stochastic model to understand bronchiolitis dynamics in children younger than 2 years of age considering high-quality data from the Valencia health system integrated database. Our modeling approach combines ideas from compartmental models and Bayesian hierarchical Poisson models in a novel way. Finally, we develop an extension of the model that simulates the effect of potential newborn immunization scenarios on the burden of disease. We provide an app tool that estimates the expected reduction in bronchiolitis episodes for a range of different values of uptake and effectiveness.

Suggested Citation

  • Mónica López-Lacort & Ana Corberán-Vallet & Francisco J. Santonja Gómez, 2021. "A Multivariate Age-Structured Stochastic Model with Immunization Strategies to Describe Bronchiolitis Dynamics," IJERPH, MDPI, vol. 18(14), pages 1-14, July.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:14:p:7607-:d:596068
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/14/7607/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/14/7607/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. David J. Spiegelhalter & Nicola G. Best & Bradley P. Carlin & Angelika Van Der Linde, 2002. "Bayesian measures of model complexity and fit," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 64(4), pages 583-639, October.
    2. Marina Treskova & Francisco Pozo-Martin & Stefan Scholz & Viktoria Schönfeld & Ole Wichmann & Thomas Harder, 2021. "Assessment of the Effects of Active Immunisation against Respiratory Syncytial Virus (RSV) using Decision-Analytic Models: A Systematic Review with a Focus on Vaccination Strategies, Modelling Methods," PharmacoEconomics, Springer, vol. 39(3), pages 287-315, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Buddhavarapu, Prasad & Bansal, Prateek & Prozzi, Jorge A., 2021. "A new spatial count data model with time-varying parameters," Transportation Research Part B: Methodological, Elsevier, vol. 150(C), pages 566-586.
    2. Mumtaz, Haroon & Theodoridis, Konstantinos, 2017. "Common and country specific economic uncertainty," Journal of International Economics, Elsevier, vol. 105(C), pages 205-216.
    3. Jesse Elliott & Zemin Bai & Shu-Ching Hsieh & Shannon E Kelly & Li Chen & Becky Skidmore & Said Yousef & Carine Zheng & David J Stewart & George A Wells, 2020. "ALK inhibitors for non-small cell lung cancer: A systematic review and network meta-analysis," PLOS ONE, Public Library of Science, vol. 15(2), pages 1-18, February.
    4. Christina Leuker & Thorsten Pachur & Ralph Hertwig & Timothy J. Pleskac, 2019. "Do people exploit risk–reward structures to simplify information processing in risky choice?," Journal of the Economic Science Association, Springer;Economic Science Association, vol. 5(1), pages 76-94, August.
    5. Francois Olivier & Laval Guillaume, 2011. "Deviance Information Criteria for Model Selection in Approximate Bayesian Computation," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 10(1), pages 1-25, July.
    6. Raggi, Davide & Bordignon, Silvano, 2012. "Long memory and nonlinearities in realized volatility: A Markov switching approach," Computational Statistics & Data Analysis, Elsevier, vol. 56(11), pages 3730-3742.
    7. Angelica Gianfreda & Francesco Ravazzolo & Luca Rossini, 2023. "Large Time‐Varying Volatility Models for Hourly Electricity Prices," Oxford Bulletin of Economics and Statistics, Department of Economics, University of Oxford, vol. 85(3), pages 545-573, June.
    8. Rubio, F.J. & Steel, M.F.J., 2011. "Inference for grouped data with a truncated skew-Laplace distribution," Computational Statistics & Data Analysis, Elsevier, vol. 55(12), pages 3218-3231, December.
    9. Alessandri, Piergiorgio & Mumtaz, Haroon, 2019. "Financial regimes and uncertainty shocks," Journal of Monetary Economics, Elsevier, vol. 101(C), pages 31-46.
    10. Padilla, Juan L. & Azevedo, Caio L.N. & Lachos, Victor H., 2018. "Multidimensional multiple group IRT models with skew normal latent trait distributions," Journal of Multivariate Analysis, Elsevier, vol. 167(C), pages 250-268.
    11. Svetlana V. Tishkovskaya & Paul G. Blackwell, 2021. "Bayesian estimation of heterogeneous environments from animal movement data," Environmetrics, John Wiley & Sons, Ltd., vol. 32(6), September.
    12. David Macro & Jeroen Weesie, 2016. "Inequalities between Others Do Matter: Evidence from Multiplayer Dictator Games," Games, MDPI, vol. 7(2), pages 1-23, April.
    13. Tautenhahn, Susanne & Heilmeier, Hermann & Jung, Martin & Kahl, Anja & Kattge, Jens & Moffat, Antje & Wirth, Christian, 2012. "Beyond distance-invariant survival in inverse recruitment modeling: A case study in Siberian Pinus sylvestris forests," Ecological Modelling, Elsevier, vol. 233(C), pages 90-103.
    14. Julian P. T. Higgins & Simon G. Thompson & David J. Spiegelhalter, 2009. "A re‐evaluation of random‐effects meta‐analysis," Journal of the Royal Statistical Society Series A, Royal Statistical Society, vol. 172(1), pages 137-159, January.
    15. Simon Mak & Derek Bingham & Yi Lu, 2016. "A regional compound Poisson process for hurricane and tropical storm damage," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 65(5), pages 677-703, November.
    16. Xi, Yanhui & Peng, Hui & Qin, Yemei & Xie, Wenbiao & Chen, Xiaohong, 2015. "Bayesian analysis of heavy-tailed market microstructure model and its application in stock markets," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 117(C), pages 141-153.
    17. Huang, Zhaodong & Chien, Steven & Zhu, Wei & Zheng, Pengjun, 2022. "Scheduling wheel inspection for sustainable urban rail transit operation: A Bayesian approach," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 586(C).
    18. Jorge I. Figueroa-Zúñiga & Cristian L. Bayes & Víctor Leiva & Shuangzhe Liu, 2022. "Robust beta regression modeling with errors-in-variables: a Bayesian approach and numerical applications," Statistical Papers, Springer, vol. 63(3), pages 919-942, June.
    19. Leonardo Oliveira Martins & Hirohisa Kishino, 2010. "Distribution of distances between topologies and its effect on detection of phylogenetic recombination," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 62(1), pages 145-159, February.
    20. Tamal Ghosh & Malay Ghosh & Jerry J. Maples & Xueying Tang, 2022. "Multivariate Global-Local Priors for Small Area Estimation," Stats, MDPI, vol. 5(3), pages 1-16, July.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:14:p:7607-:d:596068. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.