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The Effect of Flow Rate on a Third-Generation Sub-Ohm Tank Electronic Nicotine Delivery System—Comparison of CORESTA Flow Rates to More Realistic Flow Rates

Author

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  • Evan Floyd

    (Department of Occupational and Environmental Health, Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA)

  • Sara Greenlee

    (Department of Occupational and Environmental Health, Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA)

  • Toluwanimi Oni

    (Department of Occupational and Environmental Health, Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA)

  • Balaji Sadhasivam

    (Department of Otolaryngology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA)

  • Lurdes Queimado

    (Department of Otolaryngology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA)

Abstract

Many types of electronic cigarettes (ECs) are currently in use, but the default flow rate used to simulate puffing is centered on tobacco cigarette flow rates. CORESTA offers several methods and technical guides for evaluation of ECs but there are few puffing topography studies focusing on sub-ohm ECs; differences between real-world usage and that found in the literature appear large. This study focuses on how power and flow rate affect the nicotine yield of a sub-ohm EC. A puffing system (Puff3rd) has been designed and used to produce and collect EC aerosol. Nicotine yield was measured by GC–MS at three power levels and four flow rates. Data analysis was conducted in SAS using the MIXED procedure. Power, flow rate, and their interaction were all significant predictors of nicotine yield. Nicotine yield increased with both the vaping power and the puff flow rate with significant interaction of the two. Findings indicate that using the current CORESTA flow rate (1100 mL/min) to evaluate third-generation ECs underestimates nicotine yield and likely overestimates pyrolysis products. Real users are expected to have 2–3× the nicotine dose measured at 1100 mL/min, which could confound epidemiological studies seeking to link nicotine delivery to product satisfaction and acceptability.

Suggested Citation

  • Evan Floyd & Sara Greenlee & Toluwanimi Oni & Balaji Sadhasivam & Lurdes Queimado, 2021. "The Effect of Flow Rate on a Third-Generation Sub-Ohm Tank Electronic Nicotine Delivery System—Comparison of CORESTA Flow Rates to More Realistic Flow Rates," IJERPH, MDPI, vol. 18(14), pages 1-13, July.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:14:p:7535-:d:594779
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    References listed on IDEAS

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    1. Carmela Protano & Pasquale Avino & Maurizio Manigrasso & Valerio Vivaldi & Franco Perna & Federica Valeriani & Matteo Vitali, 2018. "Environmental Electronic Vape Exposure from Four Different Generations of Electronic Cigarettes: Airborne Particulate Matter Levels," IJERPH, MDPI, vol. 15(10), pages 1-10, October.
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    Cited by:

    1. Dominic L. Palazzolo & Jordan Caudill & James Baron & Kevin Cooper, 2021. "Fabrication and Validation of an Economical, Programmable, Dual-Channel, Electronic Cigarette Aerosol Generator," IJERPH, MDPI, vol. 18(24), pages 1-26, December.
    2. Evan Floyd & Toluwanimi Oni & Changjie Cai & Bilal Rehman & Jooyeon Hwang & Tyler Watson, 2022. "Validation of a High Flow Rate Puff Topography System Designed for Measurement of Sub-Ohm, Third Generation Electronic Nicotine Delivery Systems," IJERPH, MDPI, vol. 19(13), pages 1-12, June.

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