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Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors

Author

Listed:
  • Oriol Juanola

    (Gastroenterology and Hepatology, Translational Research Laboratory, Ente Ospedaliero Cantonale, Università della Svizzera Italiana, 6900 Lugano, Switzerland)

  • Sebastián Martínez-López

    (Clinical Medicine Department, Miguel Hernández University, 03550 San Juan de Alicante, Spain
    Alicante Institute for Health and Biomedical Research (ISABIAL), Hospital General Universitario de Alicante, 03010 Alicante, Spain)

  • Rubén Francés

    (Clinical Medicine Department, Miguel Hernández University, 03550 San Juan de Alicante, Spain
    Alicante Institute for Health and Biomedical Research (ISABIAL), Hospital General Universitario de Alicante, 03010 Alicante, Spain
    Networked Biomedical Research Center for Hepatic and Digestive Diseases (CIBERehd), Institute of Health Carlos III, 28029 Madrid, Spain)

  • Isabel Gómez-Hurtado

    (Alicante Institute for Health and Biomedical Research (ISABIAL), Hospital General Universitario de Alicante, 03010 Alicante, Spain
    Networked Biomedical Research Center for Hepatic and Digestive Diseases (CIBERehd), Institute of Health Carlos III, 28029 Madrid, Spain)

Abstract

Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of chronic liver disease in the Western world, probably due to the growing prevalence of obesity, metabolic diseases, and exposure to some environmental agents. In certain patients, simple hepatic steatosis can progress to non-alcoholic steatohepatitis (NASH), which can sometimes lead to liver cirrhosis and its complications including hepatocellular carcinoma. Understanding the mechanisms that cause the progression of NAFLD to NASH is crucial to be able to control the advancement of the disease. The main hypothesis considers that it is due to multiple factors that act together on genetically predisposed subjects to suffer from NAFLD including insulin resistance, nutritional factors, gut microbiota, and genetic and epigenetic factors. In this article, we will discuss the epidemiology of NAFLD, and we overview several topics that influence the development of the disease from simple steatosis to liver cirrhosis and its possible complications.

Suggested Citation

  • Oriol Juanola & Sebastián Martínez-López & Rubén Francés & Isabel Gómez-Hurtado, 2021. "Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors," IJERPH, MDPI, vol. 18(10), pages 1-24, May.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:10:p:5227-:d:554633
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    References listed on IDEAS

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    1. Valentina Tremaroli & Fredrik Bäckhed, 2012. "Functional interactions between the gut microbiota and host metabolism," Nature, Nature, vol. 489(7415), pages 242-249, September.
    2. Christian Fuchsberger & Jason Flannick & Tanya M. Teslovich & Anubha Mahajan & Vineeta Agarwala & Kyle J. Gaulton & Clement Ma & Pierre Fontanillas & Loukas Moutsianas & Davis J. McCarthy & Manuel A. , 2016. "The genetic architecture of type 2 diabetes," Nature, Nature, vol. 536(7614), pages 41-47, August.
    3. Rachel J. Perry & Varman T. Samuel & Kitt F. Petersen & Gerald I. Shulman, 2014. "The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes," Nature, Nature, vol. 510(7503), pages 84-91, June.
    Full references (including those not matched with items on IDEAS)

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