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Changes in Composition and Function of Human Intestinal Microbiota Exposed to Chlorpyrifos in Oil as Assessed by the SHIME ® Model

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  • Julie Reygner

    (Laboratoire Périnatalité et Risques Toxiques (PERITOX), UMR-I01 INERIS, UPJV-CURS CHU Sud, Avenue Laennec, F-80054 Amiens CEDEX 1, France
    UP-EGEAL 2012.10.101, Institut Polytechnique LaSalle Beauvais, 19 Rue Pierre Waguet, F-60026 Beauvais CEDEX, France
    These two authors contributed equally to the work.)

  • Claire Joly Condette

    (Laboratoire Périnatalité et Risques Toxiques (PERITOX), UMR-I01 INERIS, UPJV-CURS CHU Sud, Avenue Laennec, F-80054 Amiens CEDEX 1, France
    Laboratoire Lymphocyte Normal, Pathologique et Cancer (LNPC), EA4666, UPJV-CURS CHU Sud, Avenue Laennec, F-80054 Amiens CEDEX 1, France
    These two authors contributed equally to the work.)

  • Aurélia Bruneau

    (INRA, UMR1319 MICALIS, AMIPEM, F-78350 Jouy-en-Josas, France
    AgroParisTech, UMR1319 MICALIS, F-78350 Jouy-en-Josas, France)

  • Stéphane Delanaud

    (Laboratoire Périnatalité et Risques Toxiques (PERITOX), UMR-I01 INERIS, UPJV-CURS CHU Sud, Avenue Laennec, F-80054 Amiens CEDEX 1, France)

  • Larbi Rhazi

    (UP-EGEAL 2012.10.101, Institut Polytechnique LaSalle Beauvais, 19 Rue Pierre Waguet, F-60026 Beauvais CEDEX, France)

  • Flore Depeint

    (UP-EGEAL 2012.10.101, Institut Polytechnique LaSalle Beauvais, 19 Rue Pierre Waguet, F-60026 Beauvais CEDEX, France)

  • Latifa Abdennebi-Najar

    (UP-EGEAL 2012.10.101, Institut Polytechnique LaSalle Beauvais, 19 Rue Pierre Waguet, F-60026 Beauvais CEDEX, France)

  • Veronique Bach

    (Laboratoire Périnatalité et Risques Toxiques (PERITOX), UMR-I01 INERIS, UPJV-CURS CHU Sud, Avenue Laennec, F-80054 Amiens CEDEX 1, France)

  • Camille Mayeur

    (AgroParisTech, UMR1319 MICALIS, F-78350 Jouy-en-Josas, France
    Commensal and Probiotics-Host Interactions Laboratory, INRA, UMR1319 MICALIS, F-78350 Jouy-en-Josas, France
    These two co-senior authors contributed equally to the work.)

  • Hafida Khorsi-Cauet

    (Laboratoire Périnatalité et Risques Toxiques (PERITOX), UMR-I01 INERIS, UPJV-CURS CHU Sud, Avenue Laennec, F-80054 Amiens CEDEX 1, France
    These two co-senior authors contributed equally to the work.)

Abstract

The presence of pesticide residues in food is a public health problem. Exposure to these substances in daily life could have serious effects on the intestine—the first organ to come into contact with food contaminants. The present study investigated the impact of a low dose (1 mg/day in oil) of the pesticide chlorpyrifos (CPF) on the community structure, diversity and metabolic response of the human gut microbiota using the SHIME ® model (six reactors, representing the different parts of the gastrointestinal tract). The last three reactors (representing the colon) were inoculated with a mixture of feces from human adults. Three time points were studied: immediately before the first dose of CPF, and then after 15 and 30 days of CPF-oil administration. By using conventional bacterial culture and molecular biology methods, we showed that CPF in oil can affect the gut microbiota. It had the greatest effects on counts of culturable bacteria (with an increase in Enterobacteria, Bacteroides spp. and clostridia counts, and a decrease in bifidobacterial counts) and fermentative activity, which were colon-segment-dependent. Our results suggest that: (i) CPF in oil treatment affects the gut microbiota (although there was some discordance between the culture-dependent and culture-independent analyses); (ii) the changes are “SHIME ® -compartment” specific; and (iii) the changes are associated with minor alterations in the production of short-chain fatty acids and lactate.

Suggested Citation

  • Julie Reygner & Claire Joly Condette & Aurélia Bruneau & Stéphane Delanaud & Larbi Rhazi & Flore Depeint & Latifa Abdennebi-Najar & Veronique Bach & Camille Mayeur & Hafida Khorsi-Cauet, 2016. "Changes in Composition and Function of Human Intestinal Microbiota Exposed to Chlorpyrifos in Oil as Assessed by the SHIME ® Model," IJERPH, MDPI, vol. 13(11), pages 1-18, November.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:11:p:1088-:d:82187
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    Cited by:

    1. Jordina Balaguer-Trias & Deepika Deepika & Marta Schuhmacher & Vikas Kumar, 2022. "Impact of Contaminants on Microbiota: Linking the Gut–Brain Axis with Neurotoxicity," IJERPH, MDPI, vol. 19(3), pages 1-24, January.
    2. Federica Giambò & Michele Teodoro & Chiara Costa & Concettina Fenga, 2021. "Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review," IJERPH, MDPI, vol. 18(11), pages 1-17, May.

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