IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i21p7706-d432776.html
   My bibliography  Save this article

Monitoring of Water Quality, Antibiotic Residues, and Antibiotic-Resistant Escherichia coli in the Kshipra River in India over a 3-Year Period

Author

Listed:
  • Nada Hanna

    (Department of Global Public Health, Health Systems and Policy (HSP): Medicines Focusing Antibiotics, Karolinska Institutet, 171 77 Stockholm, Sweden
    Shared first authorship.)

  • Manju Purohit

    (Department of Global Public Health, Health Systems and Policy (HSP): Medicines Focusing Antibiotics, Karolinska Institutet, 171 77 Stockholm, Sweden
    Department of Pathology, R.D. Gardi Medical College, Ujjain 456006, India
    Shared first authorship.)

  • Vishal Diwan

    (Department of Global Public Health, Health Systems and Policy (HSP): Medicines Focusing Antibiotics, Karolinska Institutet, 171 77 Stockholm, Sweden
    Department of Public Health and Environment, R.D. Gardi Medical College, Ujjain 456006, India
    ICMR—National Institute for Research in Environmental Health, Bhopal 462030, India
    Shared first authorship.)

  • Salesh P. Chandran

    (HLL Lifecare Ltd., Kharghar Navi, Mumbai 410210, India)

  • Emilia Riggi

    (SSD Epidemiologia screening—CPO, University Hospital ‘Cittàdella Salute della Scienza’, 10126 Turin, Italy)

  • Vivek Parashar

    (Department of Public Health and Environment, R.D. Gardi Medical College, Ujjain 456006, India)

  • Ashok J. Tamhankar

    (Department of Global Public Health, Health Systems and Policy (HSP): Medicines Focusing Antibiotics, Karolinska Institutet, 171 77 Stockholm, Sweden
    Indian Initiative for Management of Antibiotic Resistance, Department of Environmental Medicine, R.D. Gardi Medical College, Ujjain 456006, India
    Shared last authorship.)

  • Cecilia Stålsby Lundborg

    (Department of Global Public Health, Health Systems and Policy (HSP): Medicines Focusing Antibiotics, Karolinska Institutet, 171 77 Stockholm, Sweden
    Shared last authorship.)

Abstract

The emergence of antibiotic resistance is a major global and environmental health issue, yet the presence of antibiotic residues and resistance in the water and sediment of a river subjected to excessive anthropogenic activities and their relationship with water quality of the river are not well studied. The objectives of the present study were a) to investigate the occurrence of antibiotic residues and antibiotic-resistant Escherichia coli ( E. coli ) in the water and sediment of the Kshipra river in India at seven selected sites during different seasons of the years 2014, 2015, and 2016 and b) to investigate the association between antibiotic residues and antibiotic-resistant E. coli in water and sediment and measured water quality parameters of the river. Antibiotic residues and resistant E. coli were present in the water and sediment and were associated with the measured water quality parameters. Sulfamethoxazole was the most frequently detected antibiotic in water at the highest concentration of 4.66 µg/L and was positively correlated with the water quality parameters. Significant ( p < 0.05) seasonal and spatial variations of antibiotic-resistant E. coli in water and sediment were found. The resistance of E. coli to antibiotics (e.g., sulfamethiazole, norfloxacin, ciprofloxacine, cefotaxime, co-trimoxazole, ceftazidime, meropenem, ampicillin, amikacin, metronidazole, tetracycline, and tigecycline) had varying associations with the measured water and sediment quality parameters. Based on the results of this study, it is suggested that regular monitoring and surveillance of water quality, including antibiotic residues and antibiotic resistance, of all rivers should be taken up as a key priority, in national and Global Action Plans as these can have implications for the buildup of antibiotic resistance.

Suggested Citation

  • Nada Hanna & Manju Purohit & Vishal Diwan & Salesh P. Chandran & Emilia Riggi & Vivek Parashar & Ashok J. Tamhankar & Cecilia Stålsby Lundborg, 2020. "Monitoring of Water Quality, Antibiotic Residues, and Antibiotic-Resistant Escherichia coli in the Kshipra River in India over a 3-Year Period," IJERPH, MDPI, vol. 17(21), pages 1-22, October.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:21:p:7706-:d:432776
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/21/7706/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/17/21/7706/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Rutuja Dhawde & Ragini Macaden & Dhananjaya Saranath & Kayzad Nilgiriwala & Appasaheb Ghadge & Tannaz Birdi, 2018. "Antibiotic Resistance Characterization of Environmental E. coli Isolated from River Mula-Mutha, Pune District, India," IJERPH, MDPI, vol. 15(6), pages 1-15, June.
    2. Vishal Diwan & Nada Hanna & Manju Purohit & Salesh Chandran & Emilia Riggi & Vivek Parashar & Ashok J. Tamhankar & Cecilia Stålsby Lundborg, 2018. "Seasonal Variations in Water-Quality, Antibiotic Residues, Resistant Bacteria and Antibiotic Resistance Genes of Escherichia coli Isolates from Water and Sediments of the Kshipra River in Central Indi," IJERPH, MDPI, vol. 15(6), pages 1-16, June.
    3. Vishal Diwan & Manju Purohit & Salesh Chandran & Vivek Parashar & Harshada Shah & Vijay K. Mahadik & Cecilia Stålsby Lundborg & Ashok J. Tamhankar, 2017. "A Three-Year Follow-Up Study of Antibiotic and Metal Residues, Antibiotic Resistance and Resistance Genes, Focusing on Kshipra—A River Associated with Holy Religious Mass-Bathing in India: Protocol Pa," IJERPH, MDPI, vol. 14(6), pages 1-13, May.
    4. Hetty Blaak & Gretta Lynch & Ronald Italiaander & Raditijo A Hamidjaja & Franciska M Schets & Ana Maria de Roda Husman, 2015. "Multidrug-Resistant and Extended Spectrum Beta-Lactamase-Producing Escherichia coli in Dutch Surface Water and Wastewater," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-16, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ashok J. Tamhankar & Cecilia Stålsby Lundborg, 2019. "Antimicrobials and Antimicrobial Resistance in the Environment and Its Remediation: A Global One Health Perspective," IJERPH, MDPI, vol. 16(23), pages 1-7, November.
    2. Herbert Galler & Gebhard Feierl & Christian Petternel & Franz F. Reinthaler & Doris Haas & Juliana Habib & Clemens Kittinger & Josefa Luxner & Gernot Zarfel, 2018. "Multiresistant Bacteria Isolated from Activated Sludge in Austria," IJERPH, MDPI, vol. 15(3), pages 1-11, March.
    3. Laura C. Scott & Nicholas Lee & Tiong Gim Aw, 2020. "Antibiotic Resistance in Minimally Human-Impacted Environments," IJERPH, MDPI, vol. 17(11), pages 1-12, June.
    4. Keerthana Rajagopal & Sujith J. Chandy & Jay P. Graham, 2021. "A One Health Review of Community-Acquired Antimicrobial-Resistant Escherichia coli in India," IJERPH, MDPI, vol. 18(22), pages 1-15, November.
    5. Sharon P. Nappier & Krista Liguori & Audrey M. Ichida & Jill R. Stewart & Kaedra R. Jones, 2020. "Antibiotic Resistance in Recreational Waters: State of the Science," IJERPH, MDPI, vol. 17(21), pages 1-28, October.
    6. Nurul Athirah Naserrudin & Mohammad Saffree Jeffree & Nirmal Kaur & Syed Sharizman Syed Abdul Rahim & Mohd Yusof Ibrahim, 2022. "Study on the Development of a Conceptual Framework to Identify the Risk Factors of Diabetic Retinopathy among Diabetic Patients: A Concept Paper," IJERPH, MDPI, vol. 19(19), pages 1-10, September.
    7. Vishal Diwan & Nada Hanna & Manju Purohit & Salesh Chandran & Emilia Riggi & Vivek Parashar & Ashok J. Tamhankar & Cecilia Stålsby Lundborg, 2018. "Seasonal Variations in Water-Quality, Antibiotic Residues, Resistant Bacteria and Antibiotic Resistance Genes of Escherichia coli Isolates from Water and Sediments of the Kshipra River in Central Indi," IJERPH, MDPI, vol. 15(6), pages 1-16, June.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:21:p:7706-:d:432776. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.