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Persistent Organic Pollutant-Mediated Insulin Resistance

Author

Listed:
  • Yeon A. Kim

    (Department of Anatomy and Cell Biology and Mitochondria Hub Regulation Center, Dong-A University College of Medicine, Busan 49201, Korea
    Department of Anesthesiology and Pain Medicine, Gyeongsang National University Changwon Hospital, Changwon 51472, Korea
    Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju 52727, Korea)

  • Joon Beom Park

    (Department of Anatomy and Cell Biology and Mitochondria Hub Regulation Center, Dong-A University College of Medicine, Busan 49201, Korea)

  • Min Seok Woo

    (Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Korea)

  • Sang Yeob Lee

    (Department of Anatomy and Cell Biology and Mitochondria Hub Regulation Center, Dong-A University College of Medicine, Busan 49201, Korea
    Department of Rheumatology, Dong-A University College of Medicine, Busan 49201, Korea)

  • Hye Young Kim

    (Department of Anatomy and Cell Biology and Mitochondria Hub Regulation Center, Dong-A University College of Medicine, Busan 49201, Korea)

  • Young Hyun Yoo

    (Department of Anatomy and Cell Biology and Mitochondria Hub Regulation Center, Dong-A University College of Medicine, Busan 49201, Korea)

Abstract

Persistent organic pollutants (POPs) such as organochlorine (OC) pesticides, polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs) have become wide-spread environmental contaminants as a consequence of their extensive use, long-range transport, and persistence. Because POPs are highly resistant to metabolic degradation, humans bioaccumulate these lipophilic and hydrophobic pollutants in fatty tissues for many years. Previous studies have demonstrated that POPs including PCBs are involved in the development of diabetes mellitus (DM) type 2 and insulin resistance. Numerous epidemiological studies suggest an association between POP burden and DM type 2/metabolic syndrome. In addition, several experimental studies have provided additional evidence supporting the association between POP exposure and DM type 2 or insulin resistance. Epidemiological and experimental studies have provided compelling evidence indicating that exposure to POPs increases the risk of developing insulin resistance and metabolic disorders. However, the detailed molecular mechanism underlying POP-induced insulin resistance is yet to be elucidated. In this article, we review literature that has reported on the association between POP burden and insulin resistance and the mechanism underlying POP-induced insulin resistance, and discuss implications for public health.

Suggested Citation

  • Yeon A. Kim & Joon Beom Park & Min Seok Woo & Sang Yeob Lee & Hye Young Kim & Young Hyun Yoo, 2019. "Persistent Organic Pollutant-Mediated Insulin Resistance," IJERPH, MDPI, vol. 16(3), pages 1-14, February.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:3:p:448-:d:203271
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    References listed on IDEAS

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    1. Schecter, A. & Le Cao Dai & Thuy, L.T.B. & Hoang Trong Quynh & Dinh Quang Minh & Hoang Dinh Cau & Pham Hoang Phiet & Phuong, N.T.N. & Constable, J.D. & Baughman, R. & Papke, O. & Ryan, J.J. & Furst, P, 1995. "Agent Orange and the Vietnamese: The persistence of elevated dioxin levels in human tissues," American Journal of Public Health, American Public Health Association, vol. 85(4), pages 516-522.
    2. Kezhong Zhang & Randal J. Kaufman, 2008. "From endoplasmic-reticulum stress to the inflammatory response," Nature, Nature, vol. 454(7203), pages 455-462, July.
    3. K. Teoman Uysal & Sarah M. Wiesbrock & Michael W. Marino & Gkhan S. Hotamisligil, 1997. "Protection from obesity-induced insulin resistance in mice lacking TNF-α function," Nature, Nature, vol. 389(6651), pages 610-614, October.
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    Cited by:

    1. Ladan Rokni & Mehdi Rezaei & Mahdi Rafieizonooz & Elnaz Khankhajeh & Ali Akbar Mohammadi & Shahabaldin Rezania, 2023. "Effect of Persistent Organic Pollutants on Human Health in South Korea: A Review of the Reported Diseases," Sustainability, MDPI, vol. 15(14), pages 1-19, July.
    2. Teresiah M. Mungai & Jun Wang, 2019. "Occurrence and Toxicological Risk Evaluation of Organochlorine Pesticides from Suburban Soils of Kenya," IJERPH, MDPI, vol. 16(16), pages 1-13, August.
    3. Naffisah Othman & Zaliha Ismail & Mohamad Ikhsan Selamat & Siti Hamimah Sheikh Abdul Kadir & Nur Amirah Shibraumalisi, 2022. "A Review of Polychlorinated Biphenyls (PCBs) Pollution in the Air: Where and How Much Are We Exposed to?," IJERPH, MDPI, vol. 19(21), pages 1-14, October.
    4. Gaia Chiara Mannino & Elettra Mancuso & Stefano Sbrignadello & Micaela Morettini & Francesco Andreozzi & Andrea Tura, 2022. "Chemical Compounds and Ambient Factors Affecting Pancreatic Alpha-Cells Mass and Function: What Evidence?," IJERPH, MDPI, vol. 19(24), pages 1-18, December.
    5. Huohuo Wang & Juanjuan Wang & Yihua Zhu & Huiping Yan & Yifan Lu, 2021. "Effects of Different Intensity Exercise on Glucose Metabolism and Hepatic IRS/PI3K/AKT Pathway in SD Rats Exposed with TCDD," IJERPH, MDPI, vol. 18(24), pages 1-12, December.
    6. Elsi Haverinen & Mariana F. Fernandez & Vicente Mustieles & Hanna Tolonen, 2021. "Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects," IJERPH, MDPI, vol. 18(24), pages 1-19, December.

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