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From endoplasmic-reticulum stress to the inflammatory response

Author

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  • Kezhong Zhang

    (The University of Michigan Medical Center
    Present address: Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, Michigan 48201, USA.)

  • Randal J. Kaufman

    (The University of Michigan Medical Center
    The University of Michigan Medical Center
    Howard Hughes Medical Institute, The University of Michigan Medical Center)

Abstract

The endoplasmic reticulum is responsible for much of a cell's protein synthesis and folding, but it also has an important role in sensing cellular stress. Recently, it has been shown that the endoplasmic reticulum mediates a specific set of intracellular signalling pathways in response to the accumulation of unfolded or misfolded proteins, and these pathways are collectively known as the unfolded-protein response. New observations suggest that the unfolded-protein response can initiate inflammation, and the coupling of these responses in specialized cells and tissues is now thought to be fundamental in the pathogenesis of inflammatory diseases. The knowledge gained from this emerging field will aid in the development of therapies for modulating cellular stress and inflammation.

Suggested Citation

  • Kezhong Zhang & Randal J. Kaufman, 2008. "From endoplasmic-reticulum stress to the inflammatory response," Nature, Nature, vol. 454(7203), pages 455-462, July.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7203:d:10.1038_nature07203
    DOI: 10.1038/nature07203
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    Cited by:

    1. Sunyoung Jeong & Eui-Cheol Shin & Jong-Hwa Lee & Jung-Heun Ha, 2023. "Particulate Matter Elevates Ocular Inflammation and Endoplasmic Reticulum Stress in Human Retinal Pigmented Epithelium Cells," IJERPH, MDPI, vol. 20(6), pages 1-19, March.
    2. Yeon A. Kim & Joon Beom Park & Min Seok Woo & Sang Yeob Lee & Hye Young Kim & Young Hyun Yoo, 2019. "Persistent Organic Pollutant-Mediated Insulin Resistance," IJERPH, MDPI, vol. 16(3), pages 1-14, February.
    3. Maria Concetta Granieri & Carmine Rocca & Anna De Bartolo & Immacolata Cristina Nettore & Vittoria Rago & Naomi Romeo & Jessica Ceramella & Annaluisa Mariconda & Paolo Emidio Macchia & Paola Ungaro & , 2023. "Quercetin and Its Derivative Counteract Palmitate-Dependent Lipotoxicity by Inhibiting Oxidative Stress and Inflammation in Cardiomyocytes," IJERPH, MDPI, vol. 20(4), pages 1-18, February.
    4. Hancheng Mao & Geun Hyang Kim & Linxiu Pan & Ling Qi, 2024. "Regulation of leptin signaling and diet-induced obesity by SEL1L-HRD1 ER-associated degradation in POMC expressing neurons," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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