IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v16y2019i3p309-d200301.html
   My bibliography  Save this article

Clinical, Neuroimaging, and Neurophysiological Findings in Children with Microcephaly Related to Congenital Zika Virus Infection

Author

Listed:
  • Maria-Lucia C. Lage

    (Post-graduate Programme in Health Sciences, Federal University of Bahia School of Medicine, Praça XV de Novembro—Largo do Terreiro de Jesus, 40025-010 Bahia, Brazil)

  • Alessandra L. de Carvalho

    (Pediatric Rehabilitation Centre, Salvador Hospital, SARAH Network of Rehabilitation Hospitals, Avenida Tancredo Neves, Caminho das Árvores, Salvador, 41820-900 Bahia, Brazil)

  • Paloma A. Ventura

    (Pediatric Rehabilitation Centre, Salvador Hospital, SARAH Network of Rehabilitation Hospitals, Avenida Tancredo Neves, Caminho das Árvores, Salvador, 41820-900 Bahia, Brazil)

  • Tania B. Taguchi

    (Pediatric Rehabilitation Centre, Salvador Hospital, SARAH Network of Rehabilitation Hospitals, Avenida Tancredo Neves, Caminho das Árvores, Salvador, 41820-900 Bahia, Brazil)

  • Adriana S. Fernandes

    (Pediatric Rehabilitation Centre, Salvador Hospital, SARAH Network of Rehabilitation Hospitals, Avenida Tancredo Neves, Caminho das Árvores, Salvador, 41820-900 Bahia, Brazil)

  • Suely F. Pinho

    (Pediatric Rehabilitation Centre, Salvador Hospital, SARAH Network of Rehabilitation Hospitals, Avenida Tancredo Neves, Caminho das Árvores, Salvador, 41820-900 Bahia, Brazil)

  • Onildo T. Santos-Junior

    (Diagnostic Imaging Department, Salvador Hospital, SARAH Network of Rehabilitation Hospital, Avenida Tancredo Neves, Caminho das ÁrvoresSalvador, 41820-900 Bahia, Brazil)

  • Clara L. Ramos

    (Bahiana School of Medicine, Bahiana Foundation for Science Development, Dom João VI, Salvador, 40290-000 Bahia, Brazil)

  • Cristiana M. Nascimento-Carvalho

    (Post-graduate Programme in Health Sciences, Federal University of Bahia School of Medicine, Praça XV de Novembro—Largo do Terreiro de Jesus, 40025-010 Bahia, Brazil
    Departament of Paediatrics, Federal University of Bahia School of Medicine, Praça XV de Novembro—Largo do Terreiro de Jesus, 40025-010 Bahia, Brazil)

Abstract

Zika virus (ZIKV) infection appeared in Brazil in 2015, causing an epidemic outbreak with increased rates of microcephaly and other serious birth disorders. We reviewed 102 cases of children who were diagnosed with microcephaly at birth and who had gestational exposure to ZIKV during the outbreak. We describe the clinical, neuroimaging, and neurophysiological findings. Most mothers (81%) reported symptoms of ZIKV infection, especially cutaneous rash, during the first trimester of pregnancy. The microcephaly was severe in 54.9% of the cases. All infants presented with brain malformations. The most frequent neuroimaging findings were cerebral atrophy (92.1%), ventriculomegaly (92.1%), malformation of cortical development (85.1%), and cortical–subcortical calcifications (80.2%). Abnormalities in neurological exams were found in 97.0% of the cases, epileptogenic activity in 56.3%, and arthrogryposis in 10.8% of the infants. The sensorineural screening suggested hearing loss in 17.3% and visual impairment in 14.1% of the infants. This group of infants who presented with microcephaly and whose mothers were exposed to ZIKV early during pregnancy showed clinical and radiological criteria for congenital ZIKV infection. A high frequency of brain abnormalities and signs of early neurological disorders were found, and epileptogenic activity and signs of sensorineural alterations were common. This suggests that microcephaly can be associated with a worst spectrum of neurological manifestations.

Suggested Citation

  • Maria-Lucia C. Lage & Alessandra L. de Carvalho & Paloma A. Ventura & Tania B. Taguchi & Adriana S. Fernandes & Suely F. Pinho & Onildo T. Santos-Junior & Clara L. Ramos & Cristiana M. Nascimento-Carv, 2019. "Clinical, Neuroimaging, and Neurophysiological Findings in Children with Microcephaly Related to Congenital Zika Virus Infection," IJERPH, MDPI, vol. 16(3), pages 1-9, January.
  • Handle: RePEc:gam:jijerp:v:16:y:2019:i:3:p:309-:d:200301
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/16/3/309/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/16/3/309/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Haryelle Náryma Confessor Ferreira & Veronica Schiariti & Isabelly Cristina Rodrigues Regalado & Klayton Galante Sousa & Silvana Alves Pereira & Carla Patrícia Novaes dos Santos Fechine & Egmar Longo, 2018. "Functioning and Disability Profile of Children with Microcephaly Associated with Congenital Zika Virus Infection," IJERPH, MDPI, vol. 15(6), pages 1-14, May.
    2. Thaís Lorena Barbosa de França & Wilton Rodrigues Medeiros & Nilba Lima de Souza & Egmar Longo & Silvana Alves Pereira & Thamyris Barbosa de Oliveira França & Klayton Galante Sousa, 2018. "Growth and Development of Children with Microcephaly Associated with Congenital Zika Virus Syndrome in Brazil," IJERPH, MDPI, vol. 15(9), pages 1-11, September.
    3. Rachel Lowe & Christovam Barcellos & Patrícia Brasil & Oswaldo G. Cruz & Nildimar Alves Honório & Hannah Kuper & Marilia Sá Carvalho, 2018. "The Zika Virus Epidemic in Brazil: From Discovery to Future Implications," IJERPH, MDPI, vol. 15(1), pages 1-18, January.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Deborah Juarbe-Rey & Adriana Obén Pérez & Roberto Papo Christian P. Santoni & Melissa Ramírez Ramírez & Mildred Vera, 2018. "Using Risk Communication Strategies for Zika Virus Prevention and Control Driven by Community-Based Participatory Research," IJERPH, MDPI, vol. 15(11), pages 1-11, November.
    2. Elena Marbán-Castro & Ana Villén-Gonzalvo & Cristina Enguita-Fernàndez & Anna Marín-Cos & Clara Menéndez & Maria Maixenchs & Azucena Bardají, 2020. "Uncertainties, Fear and Stigma: Perceptions of Zika Virus among Pregnant Women in Spain," IJERPH, MDPI, vol. 17(18), pages 1-15, September.
    3. Thaís Lorena Barbosa de França & Wilton Rodrigues Medeiros & Nilba Lima de Souza & Egmar Longo & Silvana Alves Pereira & Thamyris Barbosa de Oliveira França & Klayton Galante Sousa, 2018. "Growth and Development of Children with Microcephaly Associated with Congenital Zika Virus Syndrome in Brazil," IJERPH, MDPI, vol. 15(9), pages 1-11, September.
    4. Silvana B. Napoli & María Paula Vitale & Pablo J. Cafiero & María Belén Micheletti & Paula Pedernera Bradichansky & Celina Lejarraga & Maria Gabriela Urinovsky & Anabella Escalante & Estela Rodriguez , 2021. "Developing a Culturally Sensitive ICF-Based Tool to Describe Functioning of Children with Autism Spectrum Disorder: TEA-CIFunciona Version 1.0 Pilot Study," IJERPH, MDPI, vol. 18(7), pages 1-18, April.
    5. Amy R. Krystosik & Andrew Curtis & A. Desiree LaBeaud & Diana M. Dávalos & Robinson Pacheco & Paola Buritica & Álvaro A. Álvarez & Madhav P. Bhatta & Jorge Humberto Rojas Palacios & Mark A. James, 2018. "Neighborhood Violence Impacts Disease Control and Surveillance: Case Study of Cali, Colombia from 2014 to 2016," IJERPH, MDPI, vol. 15(10), pages 1-20, September.
    6. Darci Neves Santos & Tânia Maria de Araújo & Leticia Marques dos Santos & Hannah Kuper & Rosana Aquino & Ismael Henrique Da Silveira & Samilly Silva Miranda & Marcos Pereira & Guilherme Loureiro Werne, 2022. "The Salvador Primary Care Longitudinal Study of Child Development (CohortDICa) Following the Zika Epidemic: Study Protocol," IJERPH, MDPI, vol. 19(5), pages 1-11, February.
    7. Miguel Rebelo & João Serrano & Pedro Duarte-Mendes & Rui Paulo & Daniel A. Marinho, 2020. "Effect of Siblings and Type of Delivery on the Development of Motor Skills in the First 48 Months of Life," IJERPH, MDPI, vol. 17(11), pages 1-11, May.
    8. Jefferson Pereira Caldas Santos & Nildimar Alves Honório & Christovam Barcellos & Aline Araújo Nobre, 2020. "A Perspective on Inhabited Urban Space: Land Use and Occupation, Heat Islands, and Precarious Urbanization as Determinants of Territorial Receptivity to Dengue in the City of Rio De Janeiro," IJERPH, MDPI, vol. 17(18), pages 1-20, September.
    9. Solène Denolly & Alexey Stukalov & Uladzimir Barayeu & Alina N. Rosinski & Paraskevi Kritsiligkou & Sebastian Joecks & Tobias P. Dick & Andreas Pichlmair & Ralf Bartenschlager, 2023. "Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    10. Egmar Longo & Ana Carolina De Campos & Amanda Spinola Barreto & Dinara Laiana de Lima Nascimento Coutinho & Monique Leite Galvão Coelho & Carolina Corsi & Karolinne Souza Monteiro & Samuel Wood Logan, 2020. "Go Zika Go: A Feasibility Protocol of a Modified Ride-on Car Intervention for Children with Congenital Zika Syndrome in Brazil," IJERPH, MDPI, vol. 17(18), pages 1-12, September.
    11. Verónica Schiariti & Egmar Longo & Alexander Shoshmin & Ludmila Kozhushko & Yanina Besstrashnova & Maria Król & Taynah Neri Correia Campos & Haryelle Náryma Confessor Ferreira & Cláudia Verissimo & Da, 2018. "Implementation of the International Classification of Functioning, Disability, and Health (ICF) Core Sets for Children and Youth with Cerebral Palsy: Global Initiatives Promoting Optimal Functioning," IJERPH, MDPI, vol. 15(9), pages 1-19, September.
    12. Verónica Schiariti & Rune J. Simeonsson & Karen Hall, 2021. "Promoting Developmental Potential in Early Childhood: A Global Framework for Health and Education," IJERPH, MDPI, vol. 18(4), pages 1-15, February.
    13. Daniel Adyro Martínez-Bello & Antonio López-Quílez & Alexander Torres Prieto, 2018. "Spatio-Temporal Modeling of Zika and Dengue Infections within Colombia," IJERPH, MDPI, vol. 15(7), pages 1-18, June.
    14. Eloise B. Skinner & Caroline K. Glidden & Andrew J. MacDonald & Erin A. Mordecai, 2023. "Human footprint is associated with shifts in the assemblages of major vector-borne diseases," Nature Sustainability, Nature, vol. 6(6), pages 652-661, June.
    15. Ana Rosa Linde Arias & Elisa Tristan-Cheever & Grace Furtado & Eduardo Siqueira, 2020. "“Too Much to Ask, Too Much to Handle”: Women’s Coping in Times of Zika," IJERPH, MDPI, vol. 17(12), pages 1-12, June.
    16. Nívia Maria Rodrigues Arrais & Claudia Rodrigues Souza Maia & Nathália Allana de Amorim Rodrigues & Rafaela Silva Moreira & Valeria Azevedo de Almeida & Silvana Alves Pereira & Maria Isabel de Moraes , 2022. "Factors Associated with Behavioral Disorders in Children with Congenital Zika Syndrome and Their Families—A Cross-Sectional Study," IJERPH, MDPI, vol. 19(15), pages 1-11, August.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:16:y:2019:i:3:p:309-:d:200301. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.