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Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors

Author

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  • Emanuele Cannizzaro

    (Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialities “Giuseppe D’Alessandro”, University of Palermo, via del Vespro 133, 90127 Palermo, Italy)

  • Tiziana Ramaci

    (Faculty of Human and Social Sciences, Kore University of Enna, 94100 Enna, Italy)

  • Luigi Cirrincione

    (Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialities “Giuseppe D’Alessandro”, University of Palermo, via del Vespro 133, 90127 Palermo, Italy)

  • Fulvio Plescia

    (Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialities “Giuseppe D’Alessandro”, University of Palermo, via del Vespro 133, 90127 Palermo, Italy)

Abstract

Work-related stress is a growing health problem in modern society. The stress response is characterized by numerous neurochemicals, neuroendocrine and immune modifications that involve various neurological systems and circuits, and regulation of the gene expression of the different receptors. In this regard, a lot of research has focused the attention on the role played by the environment in influencing gene expression, which in turn can control the stress response. In particular, genetic factors can moderate the sensitivities of specific types of neural cells or circuits mediating the imprinting of the environment on different biological systems. In this current review, we wish to analyze systematic reviews and recent experimental research on the physio-pathological mechanisms that underline stress-related responses. In particular, we analyze the relationship between genetic and epigenetic factors in the stress response.

Suggested Citation

  • Emanuele Cannizzaro & Tiziana Ramaci & Luigi Cirrincione & Fulvio Plescia, 2019. "Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors," IJERPH, MDPI, vol. 16(20), pages 1-10, October.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:20:p:4031-:d:278842
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    References listed on IDEAS

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    Cited by:

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    2. Guido A. Veldhuis & Teun Sluijs & Marianne H. J. van Zwieten & Jildau Bouwman & Noortje M. Wiezer & Heleen M. Wortelboer, 2020. "A Proof-of-Concept System Dynamics Simulation Model of the Development of Burnout and Recovery Using Retrospective Case Data," IJERPH, MDPI, vol. 17(16), pages 1-28, August.
    3. Nicola Magnavita & Carlo Chiorri & Leila Karimi & Maria Karanika-Murray, 2022. "The Impact of Quality of Work Organization on Distress and Absenteeism among Healthcare Workers," IJERPH, MDPI, vol. 19(20), pages 1-16, October.
    4. Hjördís Sigursteinsdóttir & Hafdís Skúladóttir & Thórey Agnarsdóttir & Sigrídur Halldórsdóttir, 2020. "Stressful Factors in the Working Environment, Lack of Adequate Sleep, and Musculoskeletal Pain among Nursing Unit Managers," IJERPH, MDPI, vol. 17(2), pages 1-12, January.
    5. Emanuele Cannizzaro & Luigi Cirrincione & Walter Mazzucco & Alessandro Scorciapino & Cesare Catalano & Tiziana Ramaci & Caterina Ledda & Fulvio Plescia, 2020. "Night-Time Shift Work and Related Stress Responses: A Study on Security Guards," IJERPH, MDPI, vol. 17(2), pages 1-9, January.

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