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Can Hypoxic Conditioning Improve Bone Metabolism? A Systematic Review

Author

Listed:
  • Marta Camacho-Cardenosa

    (Faculty of Sport Science, University of Extremadura, 10003 Cáceres, Spain)

  • Alba Camacho-Cardenosa

    (Faculty of Sport Science, University of Extremadura, 10003 Cáceres, Spain)

  • Rafael Timón

    (Faculty of Sport Science, University of Extremadura, 10003 Cáceres, Spain)

  • Guillermo Olcina

    (Faculty of Sport Science, University of Extremadura, 10003 Cáceres, Spain)

  • Pablo Tomas-Carus

    (Departamento de Desporto e Saúde, Escola de Ciência e Tecnologia, Universidade de Évora, 7000-812 Évora, Portugal
    Comprehensive Health Research Centre (CHRC), University of Évora, 7000-812 Évora, Portugal)

  • Javier Brazo-Sayavera

    (Instituto Superior de Educación Física, Universidad de la República, 40000 Rivera, Uruguay
    Polo de Desarrollo Universitario EFISAL, Universidad de la República, 40000 Rivera, Uruguay)

Abstract

Among other functions, hypoxia-inducible factor plays a critical role in bone–vascular coupling and bone formation. Studies have suggested that hypoxic conditioning could be a potential nonpharmacological strategy for treating skeletal diseases. However, there is no clear consensus regarding the bone metabolism response to hypoxia. Therefore, this review aims to examine the impact of different modes of hypoxia conditioning on bone metabolism. The PubMed and Web of Science databases were searched for experimental studies written in English that investigated the effects of modification of ambient oxygen on bone remodelling parameters of healthy organisms. Thirty-nine studies analysed the effect of sustained or cyclic hypoxia exposure on genetic and protein expression and mineralisation capacity of different cell models; three studies carried out in animal models implemented sustained or cyclic hypoxia; ten studies examined the effect of sustained, intermittent or cyclic hypoxia on bone health and hormonal responses in humans. Different modes of hypoxic conditioning may have different impacts on bone metabolism both in vivo and in vitro. Additional research is necessary to establish the optimal cyclical dose of oxygen concentration and exposure time.

Suggested Citation

  • Marta Camacho-Cardenosa & Alba Camacho-Cardenosa & Rafael Timón & Guillermo Olcina & Pablo Tomas-Carus & Javier Brazo-Sayavera, 2019. "Can Hypoxic Conditioning Improve Bone Metabolism? A Systematic Review," IJERPH, MDPI, vol. 16(10), pages 1-22, May.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:10:p:1799-:d:232930
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    References listed on IDEAS

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    1. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
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    Cited by:

    1. Rafael Timon & Adrián González-Custodio & Aldo Vasquez-Bonilla & Guillermo Olcina & Alejo Leal, 2022. "Intermittent Hypoxia as a Therapeutic Tool to Improve Health Parameters in Older Adults," IJERPH, MDPI, vol. 19(9), pages 1-9, April.

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