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Intermittent Hypoxia as a Therapeutic Tool to Improve Health Parameters in Older Adults

Author

Listed:
  • Rafael Timon

    (Faculty of Sport Sciences, Universidad de Extremadura, 10003 Cáceres, Spain)

  • Adrián González-Custodio

    (Faculty of Sport Sciences, Universidad de Extremadura, 10003 Cáceres, Spain)

  • Aldo Vasquez-Bonilla

    (Faculty of Sport Sciences, Universidad de Extremadura, 10003 Cáceres, Spain)

  • Guillermo Olcina

    (Faculty of Sport Sciences, Universidad de Extremadura, 10003 Cáceres, Spain)

  • Alejo Leal

    (Centro Medico Alejo Leal, 10004 Cáceres, Spain)

Abstract

Aging is associated with metabolic alterations, and with a loss of strength, muscle and bone mass. Moderate intermittent hypoxia has been proposed as a new tool to enhance health-related function. The aim of this study was to evaluate the effect of moderate intermittent hypoxia exposures on parameters related to cardiovascular and bone health in older adults. A total of 38 healthy older adults (aged 65–75 years) were divided into two groups: control group (C), and hypoxia group (H) that was subjected to an intermittent hypoxia exposure (at simulated altitude of 2500 m asl) during a 24-week period (3 days/week). Body composition, blood pressure, metabolic parameters (Cholesterol, triglycerides and glucose), C-reactive protein (CRP), vascular cell adhesion molecule-1 (VCAM-1), interleukin 8 (IL-8), interleukin 10 (IL-10), N-terminal propeptide of type I procollagen (PINP) and beta C-terminal telopeptide of collagen bone formation (b-CTX) were analyzed before and after the intervention. A repeated measures analysis of variance was performed to evaluate between-group differences. The results showed that the hypoxia group achieved after the intervention a decrease in fat mass, CRP (pro-inflammatory biomarker) and b-CTX (bone resorption biomarker), as well as an increase in PINP (bone formation biomarker). In conclusion, the intermittent hypoxia might be a useful therapeutic tool to deal with problems associated with aging, such as the increase in body fat, the loss of bone mass or low-grade inflammation.

Suggested Citation

  • Rafael Timon & Adrián González-Custodio & Aldo Vasquez-Bonilla & Guillermo Olcina & Alejo Leal, 2022. "Intermittent Hypoxia as a Therapeutic Tool to Improve Health Parameters in Older Adults," IJERPH, MDPI, vol. 19(9), pages 1-9, April.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:9:p:5339-:d:803854
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    References listed on IDEAS

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    1. Marta Camacho-Cardenosa & Alba Camacho-Cardenosa & Rafael Timón & Guillermo Olcina & Pablo Tomas-Carus & Javier Brazo-Sayavera, 2019. "Can Hypoxic Conditioning Improve Bone Metabolism? A Systematic Review," IJERPH, MDPI, vol. 16(10), pages 1-22, May.
    2. Zuyun Liu & Xi Chen & Thomas M Gill & Chao Ma & Eileen M Crimmins & Morgan E Levine, 2019. "Associations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement Study," PLOS Medicine, Public Library of Science, vol. 16(6), pages 1-22, June.
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