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Assessment of Three Antimicrobial Residue Concentrations in Broiler Chicken Droppings as a Potential Risk Factor for Public Health and Environment

Author

Listed:
  • Karina Yévenes

    (Department of Preventive Medicine, Faculty of Veterinary and Animal Sciences, University of Chile, Av. Santa Rosa, La Pintana, Santiago 11735, Chile)

  • Ekaterina Pokrant

    (Department of Preventive Medicine, Faculty of Veterinary and Animal Sciences, University of Chile, Av. Santa Rosa, La Pintana, Santiago 11735, Chile)

  • Fernando Pérez

    (Department of Preventive Medicine, Faculty of Veterinary and Animal Sciences, University of Chile, Av. Santa Rosa, La Pintana, Santiago 11735, Chile)

  • Ricardo Riquelme

    (Department of Preventive Medicine, Faculty of Veterinary and Animal Sciences, University of Chile, Av. Santa Rosa, La Pintana, Santiago 11735, Chile)

  • Constanza Avello

    (Department of Preventive Medicine, Faculty of Veterinary and Animal Sciences, University of Chile, Av. Santa Rosa, La Pintana, Santiago 11735, Chile)

  • Aldo Maddaleno

    (Laboratory of Veterinary Pharmacology, Faculty of Veterinary and Animal Sciences, University of Chile, Av. Santa Rosa, La Pintana, Santiago 11735, Chile)

  • Betty San Martín

    (Laboratory of Veterinary Pharmacology, Faculty of Veterinary and Animal Sciences, University of Chile, Av. Santa Rosa, La Pintana, Santiago 11735, Chile)

  • Javiera Cornejo

    (Department of Preventive Medicine, Faculty of Veterinary and Animal Sciences, University of Chile, Av. Santa Rosa, La Pintana, Santiago 11735, Chile)

Abstract

Tetracyclines, sulfonamides and amphenicols are broad spectrum antimicrobial drugs that are widely used in poultry farming. However, a high proportion of these drugs can be excreted at high concentrations in droppings, even after the end of a therapy course. This work intended to assess and compare concentrations of florfenicol (FF), florfenicol amine (FFa), chlortetracycline (CTC), 4-epi-chlortetracycline (4-epi-CTC), and sulfachloropyridazine (SCP) in broiler chicken droppings. To this end, 70 chickens were housed under controlled environmental conditions, and assigned to experimental groups that were treated with therapeutic doses of either 10% FF, 20% CTC, or 10% SCP. Consequently, we implemented and designed an in-house validation for three analytical methodologies, which allowed us to quantify the concentrations of these three antimicrobial drugs using liquid chromatography coupled to mass spectrometry (LC-MS/MS). Our results showed that FF and FFa concentrations were detected in chicken droppings up to day 10 after ceasing treatment, while CTC and 4-epi-CTC were detected up to day 25. As for SCP residues, these were detected up to day 21. Noticeably, CTC showed the longest excretion period, as well as the highest concentrations detected after the end of its administration using therapeutic doses.

Suggested Citation

  • Karina Yévenes & Ekaterina Pokrant & Fernando Pérez & Ricardo Riquelme & Constanza Avello & Aldo Maddaleno & Betty San Martín & Javiera Cornejo, 2018. "Assessment of Three Antimicrobial Residue Concentrations in Broiler Chicken Droppings as a Potential Risk Factor for Public Health and Environment," IJERPH, MDPI, vol. 16(1), pages 1-13, December.
    • Handle: RePEc:gam:jijerp:v:16:y:2018:i:1:p:24-:d:192496
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    References listed on IDEAS

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    1. Zhao Chen & Xiuping Jiang, 2014. "Microbiological Safety of Chicken Litter or Chicken Litter-Based Organic Fertilizers: A Review," Agriculture, MDPI, vol. 4(1), pages 1-29, January.
    2. Qingxiang Yang & Hao Zhang & Yuhui Guo & Tiantian Tian, 2016. "Influence of Chicken Manure Fertilization on Antibiotic-Resistant Bacteria in Soil and the Endophytic Bacteria of Pakchoi," IJERPH, MDPI, vol. 13(7), pages 1-12, June.
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