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Prenatal Perfluorooctyl Sulfonate Exposure and Alu DNA Hypomethylation in Cord Blood

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  • Chen-Yu Liu

    (Institute of Environmental Health, College of Public Health, National Taiwan University, Taipei 10055, Taiwan)

  • Pau-Chung Chen

    (Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei 10055, Taiwan)

  • Pei-Chen Lien

    (Institute of Environmental Health, College of Public Health, National Taiwan University, Taipei 10055, Taiwan)

  • Yi-Peng Liao

    (Institute of Environmental Health, College of Public Health, National Taiwan University, Taipei 10055, Taiwan)

Abstract

Background: Perfluoroalkyl substances (PFASs) are stable and persistent in the environment, animals, and humans. PFASs can penetrate placenta and affect fetal growth. We investigated associations between prenatal exposure to perfluorooctanoic acid (PFOA), perfluorooctyl sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluoroundecanoic acid (PFUA) and global methylation levels. Specific Aims and Methods: The study used the subjects from Taiwan Birth Panel birth cohort study, including all pregnant women who gave birth between July 2004 and June 2005 in four hospitals in Taipei city and New Taipei City. A total of 363 mother-infant pairs were included in the final analyses. PFOA, PFOS, PFNA, and PFUA were measured by UPLC-MS/MS in cord blood. LINE-1 and Alu repeated elements from cord blood was used to represent global DNA methylation levels. Multivariable regression models were used to adjust potential confounders. Results: After controlling for potential confounders, each unit increase in the natural log-transformed PFOS exposure was associated with an adjusted OR of 1.72 (95% CI: 1.03, 2.88) for low Alu methylation level when dichotomized methylation level by medium. No significant effects between PFOA, PFNA, PFUA and methylation levels in the multivariable regression models were observed. Conclusions: Our findings suggest that prenatal PFOS exposure may be associated with low Alu methylation level.

Suggested Citation

  • Chen-Yu Liu & Pau-Chung Chen & Pei-Chen Lien & Yi-Peng Liao, 2018. "Prenatal Perfluorooctyl Sulfonate Exposure and Alu DNA Hypomethylation in Cord Blood," IJERPH, MDPI, vol. 15(6), pages 1-10, May.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:6:p:1066-:d:148805
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    3. Tingley, Dustin & Yamamoto, Teppei & Hirose, Kentaro & Keele, Luke & Imai, Kosuke, 2014. "mediation: R Package for Causal Mediation Analysis," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 59(i05).
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    1. Alexis M. Temkin & Barbara A. Hocevar & David Q. Andrews & Olga V. Naidenko & Lisa M. Kamendulis, 2020. "Application of the Key Characteristics of Carcinogens to Per and Polyfluoroalkyl Substances," IJERPH, MDPI, vol. 17(5), pages 1-30, March.

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