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Immune Responses to Dengue and Zika Viruses—Guidance for T Cell Vaccine Development

Author

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  • Claude Roth

    (Functional Genetics of Infectious Diseases Unit, Institut Pasteur, 75015 Paris, France
    CNRS UMR 2000–Génomique Évolutive, Modélisation et Santé, Institut Pasteur, 75015 Paris, France)

  • Félix G. Delgado

    (Functional Genetics of Infectious Diseases Unit, Institut Pasteur, 75015 Paris, France
    CNRS UMR 2000–Génomique Évolutive, Modélisation et Santé, Institut Pasteur, 75015 Paris, France
    Virology Group, Universidad El Bosque, Bogotá D.C. 110121, Colombia)

  • Etienne Simon-Lorière

    (Functional Genetics of Infectious Diseases Unit, Institut Pasteur, 75015 Paris, France
    CNRS UMR 2000–Génomique Évolutive, Modélisation et Santé, Institut Pasteur, 75015 Paris, France)

  • Anavaj Sakuntabhai

    (Functional Genetics of Infectious Diseases Unit, Institut Pasteur, 75015 Paris, France
    CNRS UMR 2000–Génomique Évolutive, Modélisation et Santé, Institut Pasteur, 75015 Paris, France)

Abstract

Despite numerous efforts to identify the molecular and cellular effectors of the adaptive immunity that induce a long-lasting immunity against dengue or Zika virus infection, the specific mechanisms underlying such protective immunity remain largely unknown. One of the major challenges lies in the high level of dengue virus (DENV) seroprevalence in areas where Zika virus (ZIKV) is circulating. In the context of such a pre-existing DENV immunity that can exacerbate ZIKV infection and disease, and given the lack of appropriate treatment for ZIKV infection, there is an urgent need to develop an efficient vaccine against DENV and ZIKV. Notably, whereas several ZIKV vaccine candidates are currently in clinical trials, all these vaccine candidates have been designed to induce neutralizing antibodies as the primary mechanism of immune protection. Given the difficulty to elicit simultaneously high levels of neutralizing antibodies against the different DENV serotypes, and the potential impact of pre-existing subneutralizing antibodies induced upon DENV infection or vaccination on ZIKV infection and disease, additional or alternative strategies to enhance vaccine efficacy, through T cell immunity, are now being considered. In this review, we summarize recent discoveries about cross-reactive B and T cell responses against DENV and ZIKV and propose guidelines for the development of safe and efficient T cell vaccines targeting both viruses.

Suggested Citation

  • Claude Roth & Félix G. Delgado & Etienne Simon-Lorière & Anavaj Sakuntabhai, 2018. "Immune Responses to Dengue and Zika Viruses—Guidance for T Cell Vaccine Development," IJERPH, MDPI, vol. 15(2), pages 1-12, February.
  • Handle: RePEc:gam:jijerp:v:15:y:2018:i:2:p:385-:d:132941
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    References listed on IDEAS

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    1. Yang Liu & Jianying Liu & Senyan Du & Chao Shan & Kaixiao Nie & Rudian Zhang & Xiao-Feng Li & Renli Zhang & Tao Wang & Cheng-Feng Qin & Penghua Wang & Pei-Yong Shi & Gong Cheng, 2017. "Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes," Nature, Nature, vol. 545(7655), pages 482-486, May.
    2. Hayden C. Metsky & Christian B. Matranga & Shirlee Wohl & Stephen F. Schaffner & Catherine A. Freije & Sarah M. Winnicki & Kendra West & James Qu & Mary Lynn Baniecki & Adrianne Gladden-Young & Aaron , 2017. "Zika virus evolution and spread in the Americas," Nature, Nature, vol. 546(7658), pages 411-415, June.
    3. Rafael A. Larocca & Peter Abbink & Jean Pierre S. Peron & Paolo M. de A. Zanotto & M. Justin Iampietro & Alexander Badamchi-Zadeh & Michael Boyd & David Ng’ang’a & Marinela Kirilova & Ramya Nityananda, 2016. "Vaccine protection against Zika virus from Brazil," Nature, Nature, vol. 536(7617), pages 474-478, August.
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