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Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes

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  • Yang Liu

    (Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University
    School of Life Science, Tsinghua University
    SZCDC-SUSTech Joint Key Laboratory for Tropical Diseases, Shenzhen Center for Disease Control and Prevention)

  • Jianying Liu

    (Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University
    SZCDC-SUSTech Joint Key Laboratory for Tropical Diseases, Shenzhen Center for Disease Control and Prevention)

  • Senyan Du

    (Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University)

  • Chao Shan

    (and Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch)

  • Kaixiao Nie

    (Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University)

  • Rudian Zhang

    (Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University
    School of Life Science, Tsinghua University)

  • Xiao-Feng Li

    (State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology)

  • Renli Zhang

    (SZCDC-SUSTech Joint Key Laboratory for Tropical Diseases, Shenzhen Center for Disease Control and Prevention)

  • Tao Wang

    (SZCDC-SUSTech Joint Key Laboratory for Tropical Diseases, Shenzhen Center for Disease Control and Prevention
    Southern University of Science and Technology, Nanshan)

  • Cheng-Feng Qin

    (State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology)

  • Penghua Wang

    (School of Medicine, New York Medical College)

  • Pei-Yong Shi

    (and Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch)

  • Gong Cheng

    (Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University
    SZCDC-SUSTech Joint Key Laboratory for Tropical Diseases, Shenzhen Center for Disease Control and Prevention)

Abstract

A mutation that increases the secretion of Zika virus non-structural protein 1 (NS1) in infected hosts enhances the ability of the virus to infect its mosquito vector Aedes aegypti and might have contributed to the recent Zika epidemic.

Suggested Citation

  • Yang Liu & Jianying Liu & Senyan Du & Chao Shan & Kaixiao Nie & Rudian Zhang & Xiao-Feng Li & Renli Zhang & Tao Wang & Cheng-Feng Qin & Penghua Wang & Pei-Yong Shi & Gong Cheng, 2017. "Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes," Nature, Nature, vol. 545(7655), pages 482-486, May.
    • Handle: RePEc:nat:nature:v:545:y:2017:i:7655:d:10.1038_nature22365
    DOI: 10.1038/nature22365
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    Cited by:

    1. Huang, He & Chen, Yahong & Ma, Yefeng, 2021. "Modeling the competitive diffusions of rumor and knowledge and the impacts on epidemic spreading," Applied Mathematics and Computation, Elsevier, vol. 388(C).
    2. Wei Yang & Li-Bo Liu & Feng-Liang Liu & Yan-Hua Wu & Zi-Da Zhen & Dong-Ying Fan & Zi-Yang Sheng & Zheng-Ran Song & Jia-Tong Chang & Yong-Tang Zheng & Jing An & Pei-Gang Wang, 2023. "Single-cell RNA sequencing reveals the fragility of male spermatogenic cells to Zika virus-induced complement activation," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Jimena Barbeito-Andrés & Lavínia Schuler-Faccini & Patricia Pestana Garcez, 2018. "Why is congenital Zika syndrome asymmetrically distributed among human populations?," PLOS Biology, Public Library of Science, vol. 16(8), pages 1-11, August.
    4. Guang-Yuan Song & Xing-Yao Huang & Meng-Jiao He & Hang-Yu Zhou & Rui-Ting Li & Ying Tian & Yan Wang & Meng-Li Cheng & Xiang Chen & Rong-Rong Zhang & Chao Zhou & Jia Zhou & Xian-Yang Fang & Xiao-Feng L, 2023. "A single amino acid substitution in the capsid protein of Zika virus contributes to a neurovirulent phenotype," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    5. Claude Roth & Félix G. Delgado & Etienne Simon-Lorière & Anavaj Sakuntabhai, 2018. "Immune Responses to Dengue and Zika Viruses—Guidance for T Cell Vaccine Development," IJERPH, MDPI, vol. 15(2), pages 1-12, February.

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