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Vaccine protection against Zika virus from Brazil

Author

Listed:
  • Rafael A. Larocca

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Peter Abbink

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Jean Pierre S. Peron

    (University of São Paulo)

  • Paolo M. de A. Zanotto

    (University of São Paulo)

  • M. Justin Iampietro

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Alexander Badamchi-Zadeh

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Michael Boyd

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • David Ng’ang’a

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Marinela Kirilova

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Ramya Nityanandam

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Noe B. Mercado

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Zhenfeng Li

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Edward T. Moseley

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Christine A. Bricault

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Erica N. Borducchi

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Patricia B. Giglio

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • David Jetton

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • George Neubauer

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Joseph P. Nkolola

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Lori F. Maxfield

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Rafael A. De La Barrera

    (Walter Reed Army Institute of Research)

  • Richard G. Jarman

    (Walter Reed Army Institute of Research)

  • Kenneth H. Eckels

    (Walter Reed Army Institute of Research)

  • Nelson L. Michael

    (Walter Reed Army Institute of Research)

  • Stephen J. Thomas

    (Walter Reed Army Institute of Research)

  • Dan H. Barouch

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
    Ragon Institute of MGH, MIT, and Harvard)

Abstract

The authors test several candidate vaccines for Zika virus in mouse models and show that single-shot DNA vaccines and inactivated virus vaccines provide complete protection against Zika virus isolates from Brazil and Puerto Rico.

Suggested Citation

  • Rafael A. Larocca & Peter Abbink & Jean Pierre S. Peron & Paolo M. de A. Zanotto & M. Justin Iampietro & Alexander Badamchi-Zadeh & Michael Boyd & David Ng’ang’a & Marinela Kirilova & Ramya Nityananda, 2016. "Vaccine protection against Zika virus from Brazil," Nature, Nature, vol. 536(7617), pages 474-478, August.
    • Handle: RePEc:nat:nature:v:536:y:2016:i:7617:d:10.1038_nature18952
    DOI: 10.1038/nature18952
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    Cited by:

    1. Jin-Na Wang & Feng Ling, 2016. "Zika Virus Infection and Microcephaly: Evidence for a Causal Link," IJERPH, MDPI, vol. 13(10), pages 1-9, October.
    2. Claude Roth & Félix G. Delgado & Etienne Simon-Lorière & Anavaj Sakuntabhai, 2018. "Immune Responses to Dengue and Zika Viruses—Guidance for T Cell Vaccine Development," IJERPH, MDPI, vol. 15(2), pages 1-12, February.
    3. Ohid Yaqub & Javier A Luna & Duncan Aq Moore & Alfredo Yegros-Yegros, 2022. "Responding to a disease with resources from other diseases: Evidence from Zika vaccine research dynamics [Protective Efficacy of Multiple Vaccine Platforms against Zika Virus Challenge in Rhesus Mo," Science and Public Policy, Oxford University Press, vol. 49(6), pages 942-950.

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