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Zika Virus Infection and Microcephaly: Evidence for a Causal Link

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  • Jin-Na Wang

    (Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, China)

  • Feng Ling

    (Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, China)

Abstract

Zika virus (ZIKV) is a flavivirus related to the Dengue, yellow fever and West Nile viruses. Since the explosive outbreaks of ZIKV in Latin America in 2015, a sudden increase in the number of microcephaly cases has been observed in infants of women who were pregnant when they contracted the virus. The severity of this condition raises grave concerns, and extensive studies on the possible link between ZIKV infection and microcephaly have been conducted. There is substantial evidence suggesting that there is a causal link between ZIKV and microcephaly, however, future studies are warranted to solidify this association. To summarize the most recent evidence on this issue and provide perspectives for future studies, we reviewed the literature to identify existing evidence of the causal link between ZIKV infection and microcephaly within research related to the epidemics, laboratory diagnosis, and possible mechanisms.

Suggested Citation

  • Jin-Na Wang & Feng Ling, 2016. "Zika Virus Infection and Microcephaly: Evidence for a Causal Link," IJERPH, MDPI, vol. 13(10), pages 1-9, October.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:10:p:1031-:d:81034
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    References listed on IDEAS

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    1. Rafael A. Larocca & Peter Abbink & Jean Pierre S. Peron & Paolo M. de A. Zanotto & M. Justin Iampietro & Alexander Badamchi-Zadeh & Michael Boyd & David Ng’ang’a & Marinela Kirilova & Ramya Nityananda, 2016. "Vaccine protection against Zika virus from Brazil," Nature, Nature, vol. 536(7617), pages 474-478, August.
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    Cited by:

    1. Deborah Juarbe-Rey & Adriana Obén Pérez & Roberto Papo Christian P. Santoni & Melissa Ramírez Ramírez & Mildred Vera, 2018. "Using Risk Communication Strategies for Zika Virus Prevention and Control Driven by Community-Based Participatory Research," IJERPH, MDPI, vol. 15(11), pages 1-11, November.
    2. Thaís Lorena Barbosa de França & Wilton Rodrigues Medeiros & Nilba Lima de Souza & Egmar Longo & Silvana Alves Pereira & Thamyris Barbosa de Oliveira França & Klayton Galante Sousa, 2018. "Growth and Development of Children with Microcephaly Associated with Congenital Zika Virus Syndrome in Brazil," IJERPH, MDPI, vol. 15(9), pages 1-11, September.

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