IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v14y2017i7p699-d103092.html
   My bibliography  Save this article

Antibiotic Resistance and Antibiotic Resistance Genes in Escherichia coli Isolates from Hospital Wastewater in Vietnam

Author

Listed:
  • La Thi Quynh Lien

    (Health Systems and Policy (HSP): Improving the Use of Medicines, Department of Public Health Sciences, Karolinska Institutet, Tomtebodavägen 18A, 17177 Stockholm, Sweden
    Department of Pharmaceutical Management and Pharmaco-Economics, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hoan Kiem District, Hanoi 110403, Vietnam)

  • Pham Thi Lan

    (Department of Dermatology and Venereology, Department of Family Medicine, Department of Microbiology, Hanoi Medical University, 01 Ton That Tung, Dong Da District, Hanoi 116516, Vietnam)

  • Nguyen Thi Kim Chuc

    (Department of Dermatology and Venereology, Department of Family Medicine, Department of Microbiology, Hanoi Medical University, 01 Ton That Tung, Dong Da District, Hanoi 116516, Vietnam)

  • Nguyen Quynh Hoa

    (National Centralized Drug Procurement Centre, Vietnam Ministry of Health, 138A Giang Vo Street, Ba Dinh district, Hanoi 118401, Vietnam)

  • Pham Hong Nhung

    (Department of Dermatology and Venereology, Department of Family Medicine, Department of Microbiology, Hanoi Medical University, 01 Ton That Tung, Dong Da District, Hanoi 116516, Vietnam
    Department of Microbiology, Bach Mai Hospital, 78 Giai Phong, Dong Da District, Hanoi 116365, Vietnam)

  • Nguyen Thi Minh Thoa

    (Department of Dermatology and Venereology, Department of Family Medicine, Department of Microbiology, Hanoi Medical University, 01 Ton That Tung, Dong Da District, Hanoi 116516, Vietnam)

  • Vishal Diwan

    (Health Systems and Policy (HSP): Improving the Use of Medicines, Department of Public Health Sciences, Karolinska Institutet, Tomtebodavägen 18A, 17177 Stockholm, Sweden
    Department of Public Health & Environment, R.D. Gardi Medical College, Agar Road, Ujjain 456006, India)

  • Ashok J. Tamhankar

    (Health Systems and Policy (HSP): Improving the Use of Medicines, Department of Public Health Sciences, Karolinska Institutet, Tomtebodavägen 18A, 17177 Stockholm, Sweden
    Indian Initiative for Management of Antibiotic Resistance, Department of Environmental Medicine, R.D. Gardi Medical College, Agar Road, Ujjain 456006, India)

  • Cecilia Stålsby Lundborg

    (Health Systems and Policy (HSP): Improving the Use of Medicines, Department of Public Health Sciences, Karolinska Institutet, Tomtebodavägen 18A, 17177 Stockholm, Sweden)

Abstract

The environmental spread of antibiotic-resistant bacteria has been recognised as a growing public health threat for which hospitals play a significant role. The aims of this study were to investigate the prevalence of antibiotic resistance and antibiotic resistance genes (ARGs) in Escherichia coli isolates from hospital wastewater in Vietnam. Wastewater samples before and after treatment were collected using continuous sampling every month over a year. Standard disk diffusion and E-test were used for antibiotic susceptibility testing. Extended-spectrum beta-lactamase (ESBL) production was tested using combined disk diffusion. ARGs were detected by polymerase chain reactions. Resistance to at least one antibiotic was detected in 83% of isolates; multidrug resistance was found in 32%. The highest resistance prevalence was found for co-trimoxazole (70%) and the lowest for imipenem (1%). Forty-three percent of isolates were ESBL-producing, with the bla TEM gene being more common than bla CTX-M . Co-harbouring of the bla CTX-M , bla TEM and qepA genes was found in 46% of isolates resistant to ciprofloxacin. The large presence of antibiotic-resistant E. coli isolates combined with ARGs in hospital wastewater, even post-treatment, poses a threat to public health. It highlights the need to develop effective processes for hospital wastewater treatment plants to eliminate antibiotic resistant bacteria and ARGs.

Suggested Citation

  • La Thi Quynh Lien & Pham Thi Lan & Nguyen Thi Kim Chuc & Nguyen Quynh Hoa & Pham Hong Nhung & Nguyen Thi Minh Thoa & Vishal Diwan & Ashok J. Tamhankar & Cecilia Stålsby Lundborg, 2017. "Antibiotic Resistance and Antibiotic Resistance Genes in Escherichia coli Isolates from Hospital Wastewater in Vietnam," IJERPH, MDPI, vol. 14(7), pages 1-11, June.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:7:p:699-:d:103092
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/14/7/699/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/14/7/699/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Benson Chuks Iweriebor & Sisipho Gaqavu & Larry Chikwelu Obi & Uchechukwu U. Nwodo & Anthony I. Okoh, 2015. "Antibiotic Susceptibilities of Enterococcus Species Isolated from Hospital and Domestic Wastewater Effluents in Alice, Eastern Cape Province of South Africa," IJERPH, MDPI, vol. 12(4), pages 1-16, April.
    2. La Thi Quynh Lien & Nguyen Quynh Hoa & Nguyen Thi Kim Chuc & Nguyen Thi Minh Thoa & Ho Dang Phuc & Vishal Diwan & Nguyen Thanh Dat & Ashok J. Tamhankar & Cecilia Stålsby Lundborg, 2016. "Antibiotics in Wastewater of a Rural and an Urban Hospital before and after Wastewater Treatment, and the Relationship with Antibiotic Use—A One Year Study from Vietnam," IJERPH, MDPI, vol. 13(6), pages 1-13, June.
    3. Roseann Velez & Elizabeth Sloand, 2016. "Combating antibiotic resistance, mitigating future threats and ongoing initiatives," Journal of Clinical Nursing, John Wiley & Sons, vol. 25(13-14), pages 1886-1889, July.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Thérèse Krahnstöver & Naiara Santos & Karyn Georges & Luiza Campos & Blanca Antizar-Ladislao, 2022. "Low-Carbon Technologies to Remove Organic Micropollutants from Wastewater: A Focus on Pharmaceuticals," Sustainability, MDPI, vol. 14(18), pages 1-26, September.
    2. Amarachukwu Obayiuwana & Adeniyi Ogunjobi & Min Yang & Mark Ibekwe, 2018. "Characterization of Bacterial Communities and Their Antibiotic Resistance Profiles in Wastewaters Obtained from Pharmaceutical Facilities in Lagos and Ogun States, Nigeria," IJERPH, MDPI, vol. 15(7), pages 1-14, June.
    3. Ashok J. Tamhankar & Cecilia Stålsby Lundborg, 2019. "Antimicrobials and Antimicrobial Resistance in the Environment and Its Remediation: A Global One Health Perspective," IJERPH, MDPI, vol. 16(23), pages 1-7, November.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Antony V. Samrot & Samraj Wilson & Ram Singh Sanjay Preeth & Pandurangan Prakash & Mahendran Sathiyasree & Subramanian Saigeetha & Nagarajan Shobana & Senthilkumar Pachiyappan & Vinod Vincent Rajesh, 2023. "Sources of Antibiotic Contamination in Wastewater and Approaches to Their Removal—An Overview," Sustainability, MDPI, vol. 15(16), pages 1-25, August.
    2. Oludare Temitope Osuntokun & Agbi Mayowa & Thonda OA & Aladejana OM, 2019. "Pre/Post Plasmid Curing and Killing Kinetic Reactivity of Discorea Bulbifera Linn Against Multiple Antibiotics Resistant Clinical Isolates, Using Escherichia Coli as A Case Study," International Journal of Cell Science & Molecular Biology, Juniper Publishers Inc., vol. 6(2), pages 46-56, August.
    3. Anna Gotkowska-Płachta, 2021. "The Prevalence of Virulent and Multidrug-Resistant Enterococci in River Water and in Treated and Untreated Municipal and Hospital Wastewater," IJERPH, MDPI, vol. 18(2), pages 1-18, January.
    4. Katherine Yang & Annie Wang & Matthew Fu & Aaron Wang & Kevin Chen & Qian Jia & Zuyi Huang, 2020. "Investigation of Incidents and Trends of Antimicrobial Resistance in Foodborne Pathogens in Eight Countries from Historical Sample Data," IJERPH, MDPI, vol. 17(2), pages 1-16, January.
    5. Vishal Diwan & Manju Purohit & Salesh Chandran & Vivek Parashar & Harshada Shah & Vijay K. Mahadik & Cecilia Stålsby Lundborg & Ashok J. Tamhankar, 2017. "A Three-Year Follow-Up Study of Antibiotic and Metal Residues, Antibiotic Resistance and Resistance Genes, Focusing on Kshipra—A River Associated with Holy Religious Mass-Bathing in India: Protocol Pa," IJERPH, MDPI, vol. 14(6), pages 1-13, May.
    6. Jong Kwon Im & Sang Hun Kim & Young Seuk Kim & Soon Ju Yu, 2021. "Spatio-Temporal Distribution and Influencing Factors of Human and Veterinary Pharmaceuticals in the Tributary Surface Waters of the Han River Watershed, South Korea," IJERPH, MDPI, vol. 18(15), pages 1-15, July.
    7. Małgorzata Czatzkowska & Izabela Wolak & Monika Harnisz & Ewa Korzeniewska, 2022. "Impact of Anthropogenic Activities on the Dissemination of ARGs in the Environment—A Review," IJERPH, MDPI, vol. 19(19), pages 1-29, October.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:14:y:2017:i:7:p:699-:d:103092. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.