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Pre/Post Plasmid Curing and Killing Kinetic Reactivity of Discorea Bulbifera Linn Against Multiple Antibiotics Resistant Clinical Isolates, Using Escherichia Coli as A Case Study

Author

Listed:
  • Oludare Temitope Osuntokun
  • Agbi Mayowa

    (Department of Microbiology, Adekunle Ajasin University, Nigeria)

  • Thonda OA
  • Aladejana OM

    (Department of Biological Science, Kings University, Nigeria)

Abstract

The emergence and spread of multidrug-resistant (MDR) bacteria to commonly used antibiotics is a severe health problem and a major challenge to global drug discovery. Plasmid-mediated multidrug resistance is one of the most imperative tribulations in the treatment of infectious diseases. The use of plasmid curing agents in association with antibiotics may serve as a feasible way to control the development and spread of antibiotic resistance encoded by antibiotic resistance plasmids (R-plasmids). This has encouraged scientists to constantly search for various plasmid curing agents and the introduction of this new approach to combat the problem of antibiotic resistance. Investigation on the antimicrobial properties of Discorea bulbifera was carried out against certain clinical isolates. The antimicrobial activities of ethanol extracts of this plant against some multiple resistant isolates was carried out using agar well diffusion method.

Suggested Citation

  • Oludare Temitope Osuntokun & Agbi Mayowa & Thonda OA & Aladejana OM, 2019. "Pre/Post Plasmid Curing and Killing Kinetic Reactivity of Discorea Bulbifera Linn Against Multiple Antibiotics Resistant Clinical Isolates, Using Escherichia Coli as A Case Study," International Journal of Cell Science & Molecular Biology, Juniper Publishers Inc., vol. 6(2), pages 46-56, August.
    • Handle: RePEc:adp:ijcsmb:v:6:y:2019:i:2:p:46-56
    DOI: 10.19080/IJCSMB.2019.06.555685
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    References listed on IDEAS

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    1. Roseann Velez & Elizabeth Sloand, 2016. "Combating antibiotic resistance, mitigating future threats and ongoing initiatives," Journal of Clinical Nursing, John Wiley & Sons, vol. 25(13-14), pages 1886-1889, July.
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