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Pre-Pregnancy Maternal Exposure to Persistent Organic Pollutants and Gestational Weight Gain: A Prospective Cohort Study

Author

Listed:
  • Lindsay M. Jaacks

    (Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA)

  • Dana Boyd Barr

    (Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA)

  • Rajeshwari Sundaram

    (Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research,)

  • Jagteshwar Grewal

    (Office of the Director, Division of Intramural Population Health Research,)

  • Cuilin Zhang

    (Epidemiology Branch, Division of Intramural Population Health Research,)

  • Germaine M. Buck Louis

    (Office of the Director, Division of Intramural Population Health Research,)

Abstract

Persistent organic pollutants (POPs) have been implicated in the development of obesity in non-pregnant adults. However, few studies have explored the association of POPs with gestational weight gain (GWG), an important predictor of future risk of obesity in both the mother and offspring. We estimated the association of maternal pre-pregnancy levels of 63 POPs with GWG. Data are from women (18–40 years; n = 218) participating in a prospective cohort study. POPs were assessed using established protocols in pre-pregnancy, non-fasting blood samples. GWG was assessed using three techniques: (1) total GWG (difference between measured pre-pregnancy weight and final self-reported pre-delivery weight); (2) category based on pre-pregnancy body mass index (BMI)-specific Institute of Medicine (IOM) recommendations; and (3) area under the GWG curve (AUC). In an exploratory analysis, effects were estimated separately for women with BMI < 25 kg/m 2 versus BMI ≥ 25 kg/m 2 . Multivariable polytomous logistic regression and linear regression were used to estimate the association between each chemical or congener and the three GWG outcomes. p,p’-dichlorodiphenyl trichloroethane (p,p’-DDT) was significantly inversely associated with AUC after adjustment for lipids and pre-pregnancy BMI: beta {95% confidence interval (CI)}, −378.03 (−724.02, −32.05). Perfluorooctane sulfonate (PFOS) was significantly positively associated with AUC after adjustment for lipids among women with a BMI < 25 kg/m 2 {beta (95% CI), 280.29 (13.71, 546.86)}, but not among women with a BMI ≥ 25 kg/m 2 {beta (95% CI), 56.99 (−328.36, 442.34)}. In summary, pre-pregnancy levels of select POPs, namely, p,p’-DDT and PFOS, were moderately associated with GWG. The association between POPs and weight gain during pregnancy may be more complex than previously thought, and adiposity prior to pregnancy may be an important effect modifier.

Suggested Citation

  • Lindsay M. Jaacks & Dana Boyd Barr & Rajeshwari Sundaram & Jagteshwar Grewal & Cuilin Zhang & Germaine M. Buck Louis, 2016. "Pre-Pregnancy Maternal Exposure to Persistent Organic Pollutants and Gestational Weight Gain: A Prospective Cohort Study," IJERPH, MDPI, vol. 13(9), pages 1-12, September.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:9:p:905-:d:78040
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    References listed on IDEAS

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    1. Jillian Ashley-Martin & Linda Dodds & Tye E. Arbuckle & Anne-Sophie Morisset & Mandy Fisher & Maryse F. Bouchard & Gabriel D. Shapiro & Adrienne S. Ettinger & Patricia Monnier & Renee Dallaire & Shayn, 2016. "Maternal and Neonatal Levels of Perfluoroalkyl Substances in Relation to Gestational Weight Gain," IJERPH, MDPI, vol. 13(1), pages 1-11, January.
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    Cited by:

    1. Xiao Tan & Zaiwu Gong & Minji Huang & Zhou-Jing Wang, 2017. "Selecting Cooking Methods to Decrease Persistent Organic Pollutant Concentrations in Food of Animal Origin Using a Consensus Decision-Making Model," IJERPH, MDPI, vol. 14(2), pages 1-18, February.
    2. Marianne Levesque & Mariame Ouedraogo & Romina Fakhraei & Alysha Dingwall Harvey & Elizabeth Bratton & Mark Walker & Linda Dodds & Laura Gaudet, 2023. "Relationships of First-Trimester Body Mass Index and Weight Change with Persistent Organic Pollutant Concentrations in Pregnant Canadian Individuals," Challenges, MDPI, vol. 14(1), pages 1-15, February.

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