IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v13y2016i1p146-d62542.html
   My bibliography  Save this article

Maternal and Neonatal Levels of Perfluoroalkyl Substances in Relation to Gestational Weight Gain

Author

Listed:
  • Jillian Ashley-Martin

    (Perinatal Epidemiology Research Unit, IWK Health Centre, Halifax, NS B3K 6R8, Canada)

  • Linda Dodds

    (Department of Obstetrics and Gynecology, Dalhousie University, Halifax, NS B3K 6R8, Canada)

  • Tye E. Arbuckle

    (Health Canada, Ottawa, ON K1A 0K9, Canada)

  • Anne-Sophie Morisset

    (Sainte Justine Hospital Research Center, University of Montreal, Montreal, PQ H3T 1C5, Canada)

  • Mandy Fisher

    (Health Canada, Ottawa, ON K1A 0K9, Canada)

  • Maryse F. Bouchard

    (Department of Environmental and Occupational Health, University of Montreal, Montreal, PQ H3T 1A8, Canada)

  • Gabriel D. Shapiro

    (Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, PQ H3A 1A2, Canada)

  • Adrienne S. Ettinger

    (Departmentof Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA)

  • Patricia Monnier

    (Department of Obstetrics and Gynecology, McGill University, Montreal, PQ H3A 1A1, Canada)

  • Renee Dallaire

    (Faculty of Medicine, Laval University, Quebec City, PQ G1V 0A6, Canada)

  • Shayne Taback

    (Departments of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB R3E 3P4, Canada)

  • William Fraser

    (Departments of Obstetrics and Gynecology, University of Sherbrooke, Sherbrooke, PQ J1H 5N4, Canada)

Abstract

Perfluoroalkyl substances (PFASs) are ubiquitous, persistent pollutants widely used in the production of common household and consumer goods. There is a limited body of literature suggesting that these chemicals may alter metabolic pathways and growth trajectories. The relationship between prenatal exposures to these chemicals and gestational weight gain (GWG) has received limited attention. One objective was to analyze the associations among maternal plasma levels of three common perfluoroalkyl substances (perfluorooctanoate (PFOA), perfluorooctanesulfonate (PFOS), perfluorohexanesulfanoate (PFHxS)) and GWG. Additionally, we explored whether GWG was associated with cord blood PFAS levels. This study utilized data collected in the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a trans-Canada cohort study of 2001 pregnant women. Our analysis quantified associations between (1) maternal PFAS concentrations and GWG and (2) GWG and cord blood PFAS concentrations. Maternal PFOS concentrations were positively associated with GWG ( β = 0.39 95% CI: 0.02, 0.75). Interquartile increases in GWG were significantly associated with elevated cord blood PFOA (OR = 1.33; 95% CI: 1.13 to 1.56) and PFOS (OR = 1.20; 95% CI: 1.03 to 1.40) concentrations. No statistically significant associations were observed between GWG and either measure of PFHxS. These findings warrant elucidation of the potential underlying mechanisms.

Suggested Citation

  • Jillian Ashley-Martin & Linda Dodds & Tye E. Arbuckle & Anne-Sophie Morisset & Mandy Fisher & Maryse F. Bouchard & Gabriel D. Shapiro & Adrienne S. Ettinger & Patricia Monnier & Renee Dallaire & Shayn, 2016. "Maternal and Neonatal Levels of Perfluoroalkyl Substances in Relation to Gestational Weight Gain," IJERPH, MDPI, vol. 13(1), pages 1-11, January.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:1:p:146-:d:62542
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/13/1/146/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/13/1/146/
    Download Restriction: no
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Gehui Wang & Jianjiang Lu & Zhenni Xing & Shanman Li & Zilong Liu & Yanbin Tong, 2017. "Occurrence, Distribution, and Risk Assessment of Perfluoroalkyl Acids (PFAAs) in Muscle and Liver of Cattle in Xinjiang, China," IJERPH, MDPI, vol. 14(9), pages 1-15, August.
    2. Zhenni Xing & Jianjiang Lu & Zilong Liu & Shanman Li & Gehui Wang & Xiaolong Wang, 2016. "Occurrence of Perfluorooctanoic Acid and Perfluorooctane Sulfonate in Milk and Yogurt and Their Risk Assessment," IJERPH, MDPI, vol. 13(10), pages 1-13, October.
    3. Lindsay M. Jaacks & Dana Boyd Barr & Rajeshwari Sundaram & Jagteshwar Grewal & Cuilin Zhang & Germaine M. Buck Louis, 2016. "Pre-Pregnancy Maternal Exposure to Persistent Organic Pollutants and Gestational Weight Gain: A Prospective Cohort Study," IJERPH, MDPI, vol. 13(9), pages 1-12, September.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:13:y:2016:i:1:p:146-:d:62542. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.