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Estimation of Saliva Cotinine Cut-Off Points for Active and Passive Smoking during Pregnancy—Polish Mother and Child Cohort (REPRO_PL)

Author

Listed:
  • Kinga Polanska

    (Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland)

  • Anna Krol

    (Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland)

  • Pawel Kaluzny

    (Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland)

  • Danuta Ligocka

    (Bureau of Quality Assurance, Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland)

  • Karolina Mikolajewska

    (Department of Biological and Environmental Monitoring, Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland)

  • Seif Shaheen

    (Centre for Primary Care and Public Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, E1 2AB London, UK)

  • Robert Walton

    (Centre for Primary Care and Public Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, E1 2AB London, UK)

  • Wojciech Hanke

    (Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland)

Abstract

A reliable assessment of smoking status has significant public health implications and is essential for research purposes. The aim of this study was to determine optimal saliva cotinine cut-off values for smoking during pregnancy. The analyses were based on data from 1771 women from the Polish Mother and Child Cohort. Saliva cotinine concentrations were assessed by high performance liquid chromatography coupled with tandem mass spectrometry (HPLC-ESI + MS/MS). The saliva cotinine cut-off value for active smoking was established at 10 ng/mL (sensitivity 96%, specificity 95%) and for passive smoking at 1.5 ng/mL (sensitivity 63%, specificity 71%). About 5% of the self-reported non-smoking women were classified as smokers based on the cotinine cut-off value. Significantly more younger, single, and less educated self-reported non-smokers had a cotinine concentration higher than 10 ng/mL compared to those who were older, married, and who had a university degree. Close to 30% of the non-smokers who indicated that smoking was not allowed in their home could be classified as exposed to passive smoking based on the cut-off value. The study suggests that self-reported smoking status is a valid measure of active smoking, whereas in the case of passive smoking, a combination of questionnaire data and biomarker verification may be required.

Suggested Citation

  • Kinga Polanska & Anna Krol & Pawel Kaluzny & Danuta Ligocka & Karolina Mikolajewska & Seif Shaheen & Robert Walton & Wojciech Hanke, 2016. "Estimation of Saliva Cotinine Cut-Off Points for Active and Passive Smoking during Pregnancy—Polish Mother and Child Cohort (REPRO_PL)," IJERPH, MDPI, vol. 13(12), pages 1-15, December.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:12:p:1216-:d:84747
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    References listed on IDEAS

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    1. López-Ratón, Mónica & Rodríguez-Álvarez, María Xosé & Cadarso-Suárez, Carmen & Gude-Sampedro, Francisco, 2014. "OptimalCutpoints: An R Package for Selecting Optimal Cutpoints in Diagnostic Tests," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 61(i08).
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    Cited by:

    1. Jolanta Gromadzinska & Kinga Polanska & Lucyna Kozlowska & Karolina Mikolajewska & Iwona Stelmach & Joanna Jerzynska & Wlodzimierz Stelmach & Mariusz Grzesiak & Wojciech Hanke & Wojciech Wasowicz, 2018. "Vitamins A and E during Pregnancy and Allergy Symptoms in an Early Childhood—Lack of Association with Tobacco Smoke Exposure," IJERPH, MDPI, vol. 15(6), pages 1-13, June.
    2. Magdalena Janc & Agnieszka Jankowska & Monika Weteska & Agnieszka Brzozowska & Wojciech Hanke & Joanna Jurewicz & Mercè Garí & Kinga Polańska & Joanna Jerzyńska, 2022. "REPRO_PL-Polish Mother and Child Cohort—Exposure, Health Status, and Neurobehavioral Assessments in Adolescents—Design and Cohort Update," IJERPH, MDPI, vol. 19(21), pages 1-16, October.
    3. Ewelina Wesołowska & Agnieszka Jankowska & Elżbieta Trafalska & Paweł Kałużny & Mariusz Grzesiak & Jolanta Dominowska & Wojciech Hanke & Gemma Calamandrei & Kinga Polańska, 2019. "Sociodemographic, Lifestyle, Environmental and Pregnancy-Related Determinants of Dietary Patterns during Pregnancy," IJERPH, MDPI, vol. 16(5), pages 1-15, March.
    4. Kinga Polanska & Anna Krol & Dorota Merecz-Kot & Danuta Ligocka & Karolina Mikolajewska & Fiorino Mirabella & Flavia Chiarotti & Gemma Calamandrei & Wojciech Hanke, 2017. "Environmental Tobacco Smoke Exposure during Pregnancy and Child Neurodevelopment," IJERPH, MDPI, vol. 14(7), pages 1-12, July.
    5. Magdalena Chełchowska & Tomasz M. Maciejewski & Joanna Mazur & Joanna Gajewska & Anastasiya Zasimovich & Mariusz Ołtarzewski & Jadwiga Ambroszkiewicz, 2019. "Active Tobacco Smoke Exposure in Utero and Concentrations of Hepcidin and Selected Iron Parameters in Newborns," IJERPH, MDPI, vol. 16(11), pages 1-10, June.
    6. Magdalena Chełchowska & Joanna Gajewska & Tomasz M. Maciejewski & Joanna Mazur & Mariusz Ołtarzewski & Jadwiga Ambroszkiewicz, 2020. "Associations between Maternal and Fetal Levels of Total Adiponectin, High Molecular Weight Adiponectin, Selected Somatomedins, and Birth Weight of Infants of Smoking and Non-Smoking Mothers," IJERPH, MDPI, vol. 17(13), pages 1-14, July.

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