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Vitamins A and E during Pregnancy and Allergy Symptoms in an Early Childhood—Lack of Association with Tobacco Smoke Exposure

Author

Listed:
  • Jolanta Gromadzinska

    (Department of Biological and Environmental Monitoring, Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland)

  • Kinga Polanska

    (Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland)

  • Lucyna Kozlowska

    (Department of Dietetics, Faculty of Human Nutrition, 02-776 Warsaw, Poland)

  • Karolina Mikolajewska

    (Department of Biological and Environmental Monitoring, Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland)

  • Iwona Stelmach

    (Department of Pediatrics and Allergy, Medical University of Lodz, 90-329 Lodz, Poland)

  • Joanna Jerzynska

    (Department of Pediatrics and Allergy, Medical University of Lodz, 90-329 Lodz, Poland)

  • Wlodzimierz Stelmach

    (Department of Social and Preventive Medicine, Medical University of Lodz, 90-647 Lodz, Poland)

  • Mariusz Grzesiak

    (Polish Mother’s Memorial Hospital—Research Institute change into Polish Mother’s Memorial Hospital Research Institute)

  • Wojciech Hanke

    (Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland)

  • Wojciech Wasowicz

    (Department of Biological and Environmental Monitoring, Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland)

Abstract

Epidemiological studies have suggested an association between maternal antioxidant levels during pregnancy and development of allergic diseases in their offspring. The aim of the study was to determine plasma vitamins A and E concentration in the 1st trimester of pregnancy, at delivery and in cord blood and to search for a relationship with allergy in up to 2-year-old children who were prenatally exposed or not exposed to tobacco smoke. The study participants included 252 mother-child pairs from Polish Mother and Child Cohort. Vitamin concentrations were measured using the HPLC-UV method, smoking status—as saliva cotinine level using the HPLC-MS/MS technique. Children’s health status was assessed using a questionnaire and pediatricians/allergists examination. Cord plasma vitamin concentrations were significantly lower than their levels in maternal plasma in the 1sttrimester and at delivery ( p < 0.001). Significantly higher concentrations of vitamin E have been shown to occur during the 1st trimester of pregnancy in plasma of the women who have actively/passively smoked cigarettes compared to the non-smokers ( p < 0.02). Multivariate analysis with inclusion of a variety of confounding factors have not indicated any statistically significant associations between β-carotene, vitamins A and E and the risk of food allergy, atopic dermatitis and wheezing in their children up to 2 years of age. The interaction between smoking during pregnancy and vitamins levels on the risk of allergy was not statistically significant ( p < 0.4). The relationship between plasma concentration of vitamins A and E, and the risk of allergy in their young children has not been demonstrated.

Suggested Citation

  • Jolanta Gromadzinska & Kinga Polanska & Lucyna Kozlowska & Karolina Mikolajewska & Iwona Stelmach & Joanna Jerzynska & Wlodzimierz Stelmach & Mariusz Grzesiak & Wojciech Hanke & Wojciech Wasowicz, 2018. "Vitamins A and E during Pregnancy and Allergy Symptoms in an Early Childhood—Lack of Association with Tobacco Smoke Exposure," IJERPH, MDPI, vol. 15(6), pages 1-13, June.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:6:p:1245-:d:152060
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    References listed on IDEAS

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    1. Kinga Polanska & Anna Krol & Pawel Kaluzny & Danuta Ligocka & Karolina Mikolajewska & Seif Shaheen & Robert Walton & Wojciech Hanke, 2016. "Estimation of Saliva Cotinine Cut-Off Points for Active and Passive Smoking during Pregnancy—Polish Mother and Child Cohort (REPRO_PL)," IJERPH, MDPI, vol. 13(12), pages 1-15, December.
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