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Prevalence and Parental Risk Factors for Speech Disability Associated with Cleft Palate in Chinese Children—A National Survey

Author

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  • Chunfeng Yun

    (Institute of Population Research, Peking University, Beijing 100871, China)

  • Zhenjie Wang

    (Institute of Population Research, Peking University, Beijing 100871, China)

  • Ping He

    (Institute of Population Research, Peking University, Beijing 100871, China)

  • Chao Guo

    (Institute of Population Research, Peking University, Beijing 100871, China)

  • Gong Chen

    (Institute of Population Research, Peking University, Beijing 100871, China)

  • Xiaoying Zheng

    (Institute of Population Research, Peking University, Beijing 100871, China)

Abstract

Although the prevalence of oral clefts in China is among the highest worldwide, little is known about the prevalence of speech disability associated with cleft palate in Chinese children. The data for this study were collected from the Second China National Sample Survey on Disability, and identification of speech disability associated with cleft palate was based on consensus manuals. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). A weighted number of 112,070 disabled children affected by cleft palate were identified, yielding a prevalence of 3.45 per 10,000 children (95% CI: 3.19–3.71). A history of speech disability in the mother (OR = 20.266, 95% CI 5.788–70.959, p < 0.0001), older paternal child-bearing age (OR = 1.061, 95% CI 1.017–1.108, p = 0.0065, per year increase in age), and lower parental education (maternal: OR = 3.424, 95% CI 1.082–10.837, p = 0.0363; paternal: OR = 2.923, 95% CI 1.245–6.866, p = 0.0138) were strongly associated with risk of speech disability associated with cleft palate in the offspring. Our results showed that maternal speech disability, older paternal child-bearing age, and lower levels of parental education were independent risk factors for speech disability associated with cleft palate for children in China. These findings may have important implications for health disparities and prevention.

Suggested Citation

  • Chunfeng Yun & Zhenjie Wang & Ping He & Chao Guo & Gong Chen & Xiaoying Zheng, 2016. "Prevalence and Parental Risk Factors for Speech Disability Associated with Cleft Palate in Chinese Children—A National Survey," IJERPH, MDPI, vol. 13(11), pages 1-8, November.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:11:p:1168-:d:83572
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    References listed on IDEAS

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    1. Lupo, P.J. & Danysh, H.E. & Symanski, E. & Langlois, P.H. & Cai, Y. & Swartz, M.D., 2015. "Neighborhood-based socioeconomic position and risk of oral clefts among offspring," American Journal of Public Health, American Public Health Association, vol. 105(12), pages 2518-2525.
    2. Kerstin U Ludwig & Syeda Tasnim Ahmed & Anne C Böhmer & Nasim Bahram Sangani & Sheryil Varghese & Johanna Klamt & Hannah Schuenke & Pinar Gültepe & Andrea Hofmann & Michele Rubini & Khalid Ahmed Aldho, 2016. "Meta-analysis Reveals Genome-Wide Significance at 15q13 for Nonsyndromic Clefting of Both the Lip and the Palate, and Functional Analyses Implicate GREM1 As a Plausible Causative Gene," PLOS Genetics, Public Library of Science, vol. 12(3), pages 1-21, March.
    3. Augustine Kong & Michael L. Frigge & Gisli Masson & Soren Besenbacher & Patrick Sulem & Gisli Magnusson & Sigurjon A. Gudjonsson & Asgeir Sigurdsson & Aslaug Jonasdottir & Adalbjorg Jonasdottir & Wend, 2012. "Rate of de novo mutations and the importance of father’s age to disease risk," Nature, Nature, vol. 488(7412), pages 471-475, August.
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