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Neighborhood-based socioeconomic position and risk of oral clefts among offspring

Author

Listed:
  • Lupo, P.J.
  • Danysh, H.E.
  • Symanski, E.
  • Langlois, P.H.
  • Cai, Y.
  • Swartz, M.D.

Abstract

Objectives. We determined the association between maternal neighborhood socio economic position (SEP) and the risk of cleft lip with or without cleft palate (CL±P) or cleft palate alone (CP) in offspring. Methods. We obtained information on CL±P (n = 2555) and CP (n = 1112) cases and unaffected controls (n = 14 735) among infants delivered during 1999 to 2008 from the Texas Birth Defects Registry. Neighborhood SEP variables, drawn from the 2000 US Census, included census tract-level poverty, education, unemployment, occupation, housing, and crowding, from which we created a composite neighborhood deprivation index (NDI). We used mixed-effects logistic regression to evaluate neighborhood SEP and oral clefts. Results. Mothers with CL±P-affected offspring were more likely to live in high-NDI (adverse) areas than mothers with unaffected offspring (odds ratio [OR] = 1.20, 95% confidence interval [CI] = 1.05, 1.37). This association was strongest among Hispanic mothers (OR = 1.32, 95% CI = 1.07, 1.62). No associations were observed with CP. Conclusions. Using data from one of the world's largest active surveillance birth defects registries, we found that adverse neighborhood SEP is modestly associated with CL±P, especially among Hispanics. These findings may have important implications for health disparities prevention.

Suggested Citation

  • Lupo, P.J. & Danysh, H.E. & Symanski, E. & Langlois, P.H. & Cai, Y. & Swartz, M.D., 2015. "Neighborhood-based socioeconomic position and risk of oral clefts among offspring," American Journal of Public Health, American Public Health Association, vol. 105(12), pages 2518-2525.
    • Handle: RePEc:aph:ajpbhl:10.2105/ajph.2015.302804_5
    DOI: 10.2105/AJPH.2015.302804
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    Cited by:

    1. Chunfeng Yun & Zhenjie Wang & Ping He & Chao Guo & Gong Chen & Xiaoying Zheng, 2016. "Prevalence and Parental Risk Factors for Speech Disability Associated with Cleft Palate in Chinese Children—A National Survey," IJERPH, MDPI, vol. 13(11), pages 1-8, November.
    2. Séverine Deguen & Wahida Kihal & Maxime Jeanjean & Cindy Padilla & Denis Zmirou-Navier, 2016. "Neighborhood Deprivation and Risk of Congenital Heart Defects, Neural Tube Defects and Orofacial Clefts: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-25, October.

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