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Bifidobacteria can protect from enteropathogenic infection through production of acetate

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  • Shinji Fukuda

    (Laboratory for Epithelial Immunobiology, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
    Graduate School of Nanobioscience, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan)

  • Hidehiro Toh

    (MetaSystems Research Team, RIKEN Advanced Science Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan)

  • Koji Hase

    (Laboratory for Epithelial Immunobiology, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan)

  • Kenshiro Oshima

    (Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan)

  • Yumiko Nakanishi

    (Laboratory for Epithelial Immunobiology, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
    Graduate School of Nanobioscience, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
    Advanced NMR Metabomics Research Team, RIKEN Plant Science Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan)

  • Kazutoshi Yoshimura

    (Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan)

  • Toru Tobe

    (Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan)

  • Julie M. Clarke

    (Preventative Health National Research Flagship, CSIRO Food and Nutritional Sciences, Adelaide, South Australia 5000, Australia)

  • David L. Topping

    (Preventative Health National Research Flagship, CSIRO Food and Nutritional Sciences, Adelaide, South Australia 5000, Australia)

  • Tohru Suzuki

    (The United Graduate School of Agricultural Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan)

  • Todd D. Taylor

    (MetaSystems Research Team, RIKEN Advanced Science Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan)

  • Kikuji Itoh

    (Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan)

  • Jun Kikuchi

    (Graduate School of Nanobioscience, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
    Advanced NMR Metabomics Research Team, RIKEN Plant Science Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
    Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8601, Japan)

  • Hidetoshi Morita

    (School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Sagamihara, Kanagawa 229-8501, Japan)

  • Masahira Hattori

    (Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan)

  • Hiroshi Ohno

    (Laboratory for Epithelial Immunobiology, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
    Graduate School of Nanobioscience, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
    Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan)

Abstract

Protective effect of probiotic bacteria Bifidobacteria, sometimes used in yoghurts and other food products as 'probiotics', are natural inhabitants of the human gut and are known to protect us from infection. A possible mechanism for at least part of that protective action has now been found in the form of acetate. Oral application of a subtype of Bifidobacterium longum in mice seems to protect them from potentially fatal Escherichia coli O157:H7 by promoting host-defence mechanisms in epithelial cells.

Suggested Citation

  • Shinji Fukuda & Hidehiro Toh & Koji Hase & Kenshiro Oshima & Yumiko Nakanishi & Kazutoshi Yoshimura & Toru Tobe & Julie M. Clarke & David L. Topping & Tohru Suzuki & Todd D. Taylor & Kikuji Itoh & Jun, 2011. "Bifidobacteria can protect from enteropathogenic infection through production of acetate," Nature, Nature, vol. 469(7331), pages 543-547, January.
    • Handle: RePEc:nat:nature:v:469:y:2011:i:7331:d:10.1038_nature09646
    DOI: 10.1038/nature09646
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    Citations

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    Cited by:

    1. Itay Daybog & Oren Kolodny, 2023. "A computational framework for resolving the microbiome diversity conundrum," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Ramadass Balamurugan & Srinivasan Pugazhendhi & Gowri M. Balachander & Tamilselvan Dharmalingam & Elissa K Mortimer & Geetha L. Gopalsamy & Richard J. Woodman & Rosie Meng & David H. Alpers & Mark Man, 2019. "Effect of Native and Acetylated Dietary Resistant Starches on Intestinal Fermentative Capacity of Normal and Stunted Children in Southern India," IJERPH, MDPI, vol. 16(20), pages 1-12, October.
    3. Junling Niu & Mengmeng Cui & Xin Yang & Juan Li & Yuhui Yao & Qiuhong Guo & Ailing Lu & Xiaopeng Qi & Dongming Zhou & Chenhong Zhang & Liping Zhao & Guangxun Meng, 2023. "Microbiota-derived acetate enhances host antiviral response via NLRP3," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Julie Reygner & Claire Joly Condette & Aurélia Bruneau & Stéphane Delanaud & Larbi Rhazi & Flore Depeint & Latifa Abdennebi-Najar & Veronique Bach & Camille Mayeur & Hafida Khorsi-Cauet, 2016. "Changes in Composition and Function of Human Intestinal Microbiota Exposed to Chlorpyrifos in Oil as Assessed by the SHIME ® Model," IJERPH, MDPI, vol. 13(11), pages 1-18, November.
    5. Liangwu Qiu & Fuhong Gong & Jiang Wu & Dingyun You & Yinzhou Zhao & Lianwu Xu & Xue Cao & Fukai Bao, 2022. "Exercise Interventions Improved Sleep Quality through Regulating Intestinal Microbiota Composition," IJERPH, MDPI, vol. 19(19), pages 1-14, September.

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