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Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review

Author

Listed:
  • Federica Giambò

    (Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Occupational Medicine Section, University of Messina, 98125 Messina, Italy
    Equally contributed.)

  • Michele Teodoro

    (Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Occupational Medicine Section, University of Messina, 98125 Messina, Italy
    Equally contributed.)

  • Chiara Costa

    (Clinical and Experimental Medicine Department, University of Messina, 98125 Messina, Italy)

  • Concettina Fenga

    (Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Occupational Medicine Section, University of Messina, 98125 Messina, Italy)

Abstract

In recent years, new targets have been included between the health outcomes induced by pesticide exposure. The gastrointestinal tract is a key physical and biological barrier and it represents a primary site of exposure to toxic agents. Recently, the intestinal microbiota has emerged as a notable factor regulating pesticides’ toxicity. However, the specific mechanisms related to this interaction are not well known. In this review, we discuss the influence of pesticide exposure on the gut microbiota, discussing the factors influencing gut microbial diversity, and we summarize the updated literature. In conclusion, more studies are needed to clarify the host–microbial relationship concerning pesticide exposure and to define new prevention interventions, such as the identification of biomarkers of mucosal barrier function.

Suggested Citation

  • Federica Giambò & Michele Teodoro & Chiara Costa & Concettina Fenga, 2021. "Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review," IJERPH, MDPI, vol. 18(11), pages 1-17, May.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:11:p:5510-:d:559194
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    References listed on IDEAS

    as
    1. Julie Reygner & Claire Joly Condette & Aurélia Bruneau & Stéphane Delanaud & Larbi Rhazi & Flore Depeint & Latifa Abdennebi-Najar & Veronique Bach & Camille Mayeur & Hafida Khorsi-Cauet, 2016. "Changes in Composition and Function of Human Intestinal Microbiota Exposed to Chlorpyrifos in Oil as Assessed by the SHIME ® Model," IJERPH, MDPI, vol. 13(11), pages 1-18, November.
    2. Mikhail Y. Syromyatnikov & Mariya M. Isuwa & Olga V. Savinkova & Mariya I. Derevshchikova & Vasily N. Popov, 2020. "The Effect of Pesticides on the Microbiome of Animals," Agriculture, MDPI, vol. 10(3), pages 1-14, March.
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    Citations

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    Cited by:

    1. Joel Salazar-Flores & Sarah M. Lomelí-Martínez & Hazael R. Ceja-Gálvez & Juan H. Torres-Jasso & Luis A. Torres-Reyes & Erandis D. Torres-Sánchez, 2022. "Impacts of Pesticides on Oral Cavity Health and Ecosystems: A Review," IJERPH, MDPI, vol. 19(18), pages 1-20, September.
    2. Ahmed Massoud & Aly Derbalah & Ibrahim El-Mehasseb & Moustafa Saad Allah & Mohamed S. Ahmed & Ashraf Albrakati & Ehab Kotb Elmahallawy, 2021. "Photocatalytic Detoxification of Some Insecticides in Aqueous Media Using TiO 2 Nanocatalyst," IJERPH, MDPI, vol. 18(17), pages 1-15, September.
    3. Monica Lopes-Ferreira & Adolfo Luis Almeida Maleski & Leticia Balan-Lima & Jefferson Thiago Gonçalves Bernardo & Lucas Marques Hipolito & Ana Carolina Seni-Silva & Joao Batista-Filho & Maria Alice Pim, 2022. "Impact of Pesticides on Human Health in the Last Six Years in Brazil," IJERPH, MDPI, vol. 19(6), pages 1-19, March.

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